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Our group studies the molecular basis of plant innate immunity. We aim at deciphering the signaling events linking perception of pathogen-associated molecular patterns (PAMPs) to the establishment of immunity.

We use the leucine-rich repeats receptor kinases EFR and FLS2, which perceive bacterial EF-Tu and flagellin, respectively, as model pattern recognition receptors (PRRs).

Our work also aims at understanding how plant receptor kinases work at the molecular level and how signaling specificity is achieved between different receptor kinase-mediated signaling pathways involved in immunity and growth.

We are also exploring how outcomes of our research can be used to engineer sustainable broad-spectrum disease resistance in crops.

Latest Publications

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Mendy B, Wang'ombe MW, Radakovic ZS, Holbein J, Ilyas M, Chopra D, Holton N, Zipfel C, Grundler FM, Siddique S

Arabidopsis leucine-rich repeat receptor-like kinase NILR1 is required for induction of innate immunity to parasitic nematodes. PLoS Pathog. 2017 Apr 13;13(4):e1006284. doi: 10.1371/journal.ppat.1006284.

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Zipfel C, Oldroyd GED (2017)

Plant signalling in symbiosis and immunity. Nature 543, 328–336. doi:10.1038/nature22009

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Bücherl CA, Jarsch IK, Schudoma C, Segonzac C, Mbengue M, Robatzek S, MacLean D, Ott T, Zipfel C (2017)

Plant immune and growth receptors share common signalling components but localise to distinct plasma membrane nanodomains. eLife 2017;10.7554/eLife.25114

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de Azevedo Souza C, Li S, Lin AZ, Boutrot F, Grossmann G, Zipfel C, Somerville S (2017)

Cellulose-derived oligomers act as damage-associated molecular patterns and trigger defense-like responses. Plant Physiol. 2017 Feb 27. pii: pp.01680.2016. doi: 10.1104/pp.16.01680.

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