Cyril Zipfel Group
Our group studies the molecular basis of plant innate immunity. We aim at deciphering the signaling events linking perception of pathogen-associated molecular patterns (PAMPs) to the establishment of immunity.
We use the leucine-rich repeats receptor kinases EFR and FLS2, which perceive bacterial EF-Tu and flagellin, respectively, as model pattern recognition receptors (PRRs).
Our work also aims at understanding how plant receptor kinases work at the molecular level and how signaling specificity is achieved between different receptor kinase-mediated signaling pathways involved in immunity and growth.
We are also exploring how outcomes of our research can be used to engineer sustainable broad-spectrum disease resistance in crops.
The Zipfel group is based both at TSL and at the University of Zurich (Switzerland) (https://www.botinst.uzh.ch/en/research/plantsensing/zipfel.html). In addition to our own research, we also collaborate with researchers across TSL and contribute to joint research programmes.
Bjornson M, Pimprikar P, Nuernberger T, Zipfel C (2020)
The transcriptional landscape of Arabidopsis thaliana pattern-triggered immunity. bioRxiv preprint Dec 01, 2020 doi: https://doi.org/10.1101/2020.11.30.404566Read more
Steinbrenner AD, Muñoz-Amatriaín M, Chaparro AF, Aguilar-Venegas JM, Lo S, Okuda S, Glauser G, Dongiovanni J, Shi D, Hall M, Crubaugh D, Holton N, Zipfel C, Abagyan R, Turlings TCJ, Close TJ, Huffaker A, Schmelz EA (2020)
A receptor-like protein mediates plant immune responses to herbivore-associated molecular patterns. Proc Natl Acad Sci U S A. 2020 Nov 23:202018415. doi: 10.1073/pnas.2018415117.Read more
Derkacheva M, Yu G, Rufian JS, Jiang S, Derbyshire P, Morcillo R, Stransfeld L, Wei Y, Menke F, Zipfel C, Macho A (2020)
The Arabidopsis E3 ubiquitin ligase PUB4 regulates BIK1 homeostasis and is targeted by a bacterial type-III effector. bioRxiv preprint Oct 26, 2020 doi: https://doi.org/10.1101/2020.10.25.354514Read more
Grubb L, Derbyshire P, Dunning K, Zipfel C, Menke FLH, Monaghan J (2020)
Large-scale identification of ubiquitination sites on membrane-associated proteins in Arabidopsis thaliana seedlings. bioRxiv preprint Sept 17, 2020 doi: https://doi.org/10.1101/2020.09.16.299883Read more