Cyril Zipfel Group
Our group studies the molecular basis of plant innate immunity. We aim at deciphering the signaling events linking perception of pathogen-associated molecular patterns (PAMPs) to the establishment of immunity.
We use the leucine-rich repeats receptor kinases EFR and FLS2, which perceive bacterial EF-Tu and flagellin, respectively, as model pattern recognition receptors (PRRs).
Our work also aims at understanding how plant receptor kinases work at the molecular level and how signaling specificity is achieved between different receptor kinase-mediated signaling pathways involved in immunity and growth.
We are also exploring how outcomes of our research can be used to engineer sustainable broad-spectrum disease resistance in crops.
Perraki A, Gronnier J, Gouguet P, Boudsocq M, Deroubaix AF, Simon V, German-Retana S, Zipfel C, Bayer E, Mongrand S, Germain V, Legrand A, Habenstein B (2018)
REM1.3’s phospho-status defines its plasma membrane nanodomain organization and activity in restricting PVX cell-to-cell movement. PLoS Pathog. 2018 Nov 12;14(11):e1007378. doi: 10.1371/journal.ppat.1007378.Read more
Kadota Y, Liebrand TWH, Goto Y, Sklenar J, Derbyshire P, Menke FLH, Torres MA, Molina A, Zipfel C, Coaker G, Shirasu K (2018)
Quantitative phosphoproteomic analysis reveals common regulatory mechanisms between effector- and PAMP-triggered immunity in plants. New Phytol. 2018 Oct 9. doi: 10.1111/nph.15523.Read more
Brulé D, Villano C, Davies LJ, Trdá L, Claverie J, Héloir MC, Chiltz A, Adrian M, Darblade B, Tornero P, Stransfeld L, Boutrot F, Zipfel C, Dry IB, Poinssot B (2018)
The grapevine (Vitis vinifera) LysM receptor kinases VvLYK1-1 and VvLYK1-2 mediate chitooligosaccharide-triggered immunity. Plant Biotechnol J. 2018 Sep 26. doi: 10.1111/pbi.13017.Read more
Wan WL, Zhang L, Pruitt R, Zaidem M, Brugman R, Ma X, Krol E, Perraki A, Kilian J, Grossmann G, Stahl M, Shan L, Zipfel C, van Kan JAL, Hedrich R, Weigel D, Gust AA, Nürnberger T (2018)
Comparing Arabidopsis receptor kinase and receptor protein-mediated immune signaling reveals BIK1-dependent differences. New Phytol. 2018 Sep 25. doi: 10.1111/nph.15497.Read more