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Cyril Zipfel Group

Our group studies the molecular basis of plant innate immunity. We aim at deciphering the signaling events linking perception of pathogen-associated molecular patterns (PAMPs) to the establishment of immunity.

We use the leucine-rich repeats receptor kinases EFR and FLS2, which perceive bacterial EF-Tu and flagellin, respectively, as model pattern recognition receptors (PRRs).

Our work also aims at understanding how plant receptor kinases work at the molecular level and how signaling specificity is achieved between different receptor kinase-mediated signaling pathways involved in immunity and growth.

We are also exploring how outcomes of our research can be used to engineer sustainable broad-spectrum disease resistance in crops.

The Zipfel group is based both at TSL and at the University of Zurich (Switzerland) (https://www.botinst.uzh.ch/en/research/plantsensing/zipfel.html).  In addition to our own research, we also collaborate with researchers across TSL and contribute to joint research programmes.

Latest Publications

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Rhodes J, Roman AO, Bjornson M, Brandt B, Derbyshire P, Wyler M, Schmid M, Menke FLH, Santiago J, Zipfel C (2021)

Perception of a conserved family of plant signalling peptides by the receptor kinase HSL3. bioRxiv preprint Oct 26, 2021 doi: https://doi.org/10.1101/2021.10.25.465685

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Abarca A, Franck CM, Zipfel C (2021)

Family-wide evaluation of RAPID ALKALINIZATION FACTOR peptides. Plant Physiol. 2021 Oct 5;187(2):996-1010. doi: 10.1093/plphys/kiab308.

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Schellenberger R, Crouzet J, Nickzad A, Shu LJ, Kutschera A, Gerster T, Borie N, Dawid C, Cloutier M, Villaume S, Dhondt-Cordelier S, Hubert J, Cordelier S, Mazeyrat-Gourbeyre F, Schmid C, Ongena M, Renault JH, Haudrechy A, Hofmann T, Baillieul F, Clément C, Zipfel C, Gauthier C, Déziel E, Ranf S, Dorey S (2021)

Bacterial rhamnolipids and their 3-hydroxyalkanoate precursors activate Arabidopsis innate immunity through two independent mechanisms. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2101366118. doi: 10.1073/pnas.2101366118.

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Bender KW, Couto D, Kadota Y, Macho AP, Sklenar J, Derbyshire P, Bjornson M, DeFalco TA, Petriello A, Font Farre M, Schwessinger B, Ntoukakis V, Stransfeld L, Jones AME, Menke FLH, Cyril Zipfel C (2021)

Activation loop phosphorylaton of a non-RD receptor kinase initiates plant innate immune signaling. PNAS September 21, 2021 118 (38) e2108242118; https://doi.org/10.1073/pnas.2108242118

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