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Our group studies the molecular basis of plant innate immunity. We aim at deciphering the signaling events linking perception of pathogen-associated molecular patterns (PAMPs) to the establishment of immunity.

We use the leucine-rich repeats receptor kinases EFR and FLS2, which perceive bacterial EF-Tu and flagellin, respectively, as model pattern recognition receptors (PRRs).

Our work also aims at understanding how plant receptor kinases work at the molecular level and how signaling specificity is achieved between different receptor kinase-mediated signaling pathways involved in immunity and growth.

We are also exploring how outcomes of our research can be used to engineer sustainable broad-spectrum disease resistance in crops.

Latest Publications

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Magalhães DM, Scholte LL, Silva NV, Oliveira GC, Zipfel C, Takita MA, De Souza AA (2016)

LRR-RLK family from two Citrus species: genome-wide identification and evolutionary aspects. BMC Genomics: 17(1):623. doi: 10.1186/s12864-016-2930-9.

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Couto D, Niebergall R, Liang X, Bücherl CA, Sklenar J, Macho AP, Ntoukakis V, Derbyshire P, Altenbach D, Maclean D, Robatzek S, Uhrig J, Menke F, Zhou JM, Zipfel C (2016)

The Arabidopsis Protein Phosphatase PP2C38 Negatively Regulates the Central Immune Kinase BIK1. PLoS Pathog. 12(8):e1005811. doi: 10.1371/journal.ppat.1005811.

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Couto D, Zipfel C (2016)

Regulation of pattern recognition receptor signalling in plants. Nature Reviews Immunology (2016) doi:10.1038/nri.2016.77

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Hegenauer V, Fürst U, Kaiser B, Smoker M, Zipfel C, Felix G, Stahl M, Albert M (2016)

Detection of the plant parasite Cuscuta reflexa by a tomato cell surface receptor. Science Vol. 353, Issue 6298, pp. 478-481 doi: 10.1126/science.aaf3919

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