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Our group studies the molecular basis of plant innate immunity. We aim at deciphering the signaling events linking perception of pathogen-associated molecular patterns (PAMPs) to the establishment of immunity.

We use the leucine-rich repeats receptor kinases EFR and FLS2, which perceive bacterial EF-Tu and flagellin, respectively, as model pattern recognition receptors (PRRs).

Our work also aims at understanding how plant receptor kinases work at the molecular level and how signaling specificity is achieved between different receptor kinase-mediated signaling pathways involved in immunity and growth.

We are also exploring how outcomes of our research can be used to engineer sustainable broad-spectrum disease resistance in crops.

Latest Publications

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Ikeuchi M, Rhodes J (2017)

Latest Advances in Plant Development and Environmental Response, the inaugural Cold Spring Harbor Asia Plant Biology Meeting in Japan. Plant Cell Physiol pcx083. DOI: https://doi.org/10.1093/pcp/pcx083

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Boutrot F, Zipfel C (2017)

Function, Discovery, and Exploitation of Plant Pattern Recognition Receptors for Broad-Spectrum Disease Resistance. Annu Rev Phytopathol. 2017 Jun 15. doi: 10.1146/annurev-phyto-080614-120106.

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Van der Does D, Boutrot F, Engelsdorf T, Rhodes J, McKenna JF, Vernhettes S, Koevoets I, Tintor N, Veerabagu M, Miedes E, Segonzac C, Roux M, Breda AS, Hardtke CS, Molina A, Rep M, Testerink C, Mouille G, Höfte H, Hamann T, Zipfel C (2017)

The Arabidopsis leucine-rich repeat receptor kinase MIK2/LRR-KISS connects cell wall integrity sensing, root growth and response to abiotic and biotic stresses. PLoS Genet. 2017 Jun 12;13(6):e1006832. doi: 10.1371/journal.pgen.1006832.

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Mendy B, Wang'ombe MW, Radakovic ZS, Holbein J, Ilyas M, Chopra D, Holton N, Zipfel C, Grundler FM, Siddique S

Arabidopsis leucine-rich repeat receptor-like kinase NILR1 is required for induction of innate immunity to parasitic nematodes. PLoS Pathog. 2017 Apr 13;13(4):e1006284. doi: 10.1371/journal.ppat.1006284.

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