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Our group studies the molecular basis of plant innate immunity. We aim at deciphering the signaling events linking perception of pathogen-associated molecular patterns (PAMPs) to the establishment of immunity.

We use the leucine-rich repeats receptor kinases EFR and FLS2, which perceive bacterial EF-Tu and flagellin, respectively, as model pattern recognition receptors (PRRs).

Our work also aims at understanding how plant receptor kinases work at the molecular level and how signaling specificity is achieved between different receptor kinase-mediated signaling pathways involved in immunity and growth.

We are also exploring how outcomes of our research can be used to engineer sustainable broad-spectrum disease resistance in crops.

Latest Publications

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Bender KW, Zipfel C (2018)

Plant G-protein activation: connecting to plant receptor kinases. Cell Res. 2018 May 29. doi: 10.1038/s41422-018-0046-2.

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Ziemann S, van der Linde K, Lahrmann U, Acar B, Kaschani F, Colby T, Kaiser M, Ding Y, Schmelz E, Huffaker A, Holton N, Zipfel C, Doehlemann G(2018)

An apoplastic peptide activates salicylic acid signalling in maize. Nature Plants (2018) doi:10.1038/s41477-018-0116-y

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Wang J, Grubb LE, Wang J, Liang X, Li L, Gao C, Ma M, Feng F, Li M, Li L, Zhang X, Yu F, Xie Q, Chen S, Zipfel C, Monaghan J, Zhou J-M (2018)

A Regulatory Module Controlling Homeostasis of a Plant Immune Kinase. Molecular Cell 69, https://doi.org/10.1016/j.molcel.2017.12.026

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Smakowska-Luzan E, Mott GA, Parys K, Stegmann M, Howton TC, Layeghifard M, Neuhold J, Lehner A, Kong J, Grünwald K, Weinberger N, Satbhai SB, Mayer D, Busch W, Madalinski M, Stolt-Bergner P,Provart NJ, Mukhtar MS, Zipfel C, Desveaux D, Guttman DS, Belkhadir Y (2018)

An extracellular network of Arabidopsis leucine-rich repeat receptor kinases. Nature doi:10.1038/nature25184

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