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Mr Mark Youles

Support Officer
Synthetic Biology

My work within the TSL to date has primarily focused on the adaption and implementation of the Golden Gate modular cloning system.

In addition to this however, I have also generated various DNA constructs which the Synthetic Biology team hopes will push the currently accepted/known boundaries of the use of Synthetic Biology within the field of plant sciences.

Mr Mark Youles

mark.youles@tsl.ac.uk
+44 (0) 1603 450052

Publications

Ngou BPM, Ahn HK, Ding P, Redkar A, Brown H, Ma Y, Youles M, Tomlinson L, Jones JDG (2019)

Estradiol-inducible AvrRps4 expression reveals distinct properties of TIR-NLR-mediated effector-triggered immunity. bioRxiv preprint Jul 14, 2019 doi: https://doi.org/10.1101/701359

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Patron NJ, Orzaez D, Marillonnet S, Warzecha H, Matthewman C, Youles M, Raitskin O, Leveau A, Farré G, Rogers C, Smith A, Hibberd J, Webb AAR, Locke J, Schornack S, Ajioka J, Baulcombe DC, Zipfel C, Kamoun S, Jones JDG, Kuhn H, Robatzek S, Van Esse HP, Sanders D, Oldroyd G, Martin C, Field R, O'Connor S, Fox S, Wulff B, Miller B, Breakspear A, Radhakrishnan G, Delaux PM, Loqué D, Granell A, Tissier A, Shih P, Brutnell TP, Quick WP, Rischer H, Fraser PD, Aharoni A, Raines C, South PF, Ané JM, Hamberger BR, Langdale J, Stougaard J, Bouwmeester H, Udvardi M, Murray JAH, Ntoukakis V, Schäfer P, Denby K, Edwards KJ, Osbourn A, Haseloff J (2015)

Standards for plant synthetic biology: a common syntax for exchange of DNA parts. New Phytologist 14 Jul 2015 doi: 10.1111/nph.13532

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Engler C, Youles M, Grützner R, Ehnert T-M, Werner S, Jones JDG, Patron NJ, Marillonnet S (2014)

A Golden Gate Modular Cloning Toolbox for Plants. ACS Synth. Biol

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Youles, Holmes, Petoukhov, Nessen, Stivala , Svergun, Gherardi, (2008)

Engineering the NK1 Fragment of Hepatocyte Growth Factor/Scatter Factor as a MET Receptor Antagonist, J Mol Biol, 377(3):616-22. Epub 2008 Jan 18.

Gherardi, Sandin, Petoukhov, Finch, Youles, Ofverstedt, Miguel, Blundell, Vande Woude, Skoglund, Svergun, (2006)

Structural Basis of Hepatocyte Growth Factor/Scatter Factor and MET Signalling, Proc Natl Acad Sci U S A, 103(11):4046-51. Epub 2006 Mar 6.

Gherardi, Youles, Miguel, Blundell, Iamele, Gough, Bandyopadhyay, Hartmann, Butler, (2003)

Functional Map and Domain Structure of MET, the Product of the c-met Protooncogene and Receptor for Hepatocyte Growth Factor/Scatter Factor, Proc Natl Acad Sci U S A, 100(21):12039-44. Epub 2003 Oct 3.

Job History

2012 – present Support Officer, The Sainsbury Laboratory, Norwich, UK.

2011 – 2012 Advanced Research Assistant, Wellcome Trust Sanger Institute, Hinxton, UK.

1999 – 2011 Research Assistant, MRC/LMB, Cambridge, UK.

1994 – 1999 Research Technician, Dept. of Genetics, Cambridge, UK.