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Jonathan Jones Group

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We are interested in how plants resist disease, and in how resistance is overcome by pathogens.  To suppress host defence, pathogens secrete effector proteins into plant cells or into their apoplastic spaces.  How these effectors work, and the identity of their targets in the host, help us understand plant defence mechanisms.

We work on the following problems.

  1. How do plant NB-LRR disease resistance proteins recognize pathogen effectors and then activate defence?
  2. What are the effectors of the Arabidopsis downy mildew and white rust pathogens (Hyaloperonospora arabidopsidis and Albugo sp), and how do they suppress host defences?
  3. Can we find and clone new sources of resistance to potato late blight from wild Solanum species?

Latest Publications

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Steuernagel B, Jupe F, Witek K, Jones JD, Wulff BB (2015)

NLR-parser: Rapid annotation of plant NLR complements. Bioinformatics. 2015 Jan 12. pii: btv005. [Epub ahead of print]

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Caillaud MC, Wirthmueller L, Sklenar J, Findlay K, Piquerez SJ, Jones AM, Robatzek S, Jones JD, Faulkner C (2014)

The Plasmodesmal Protein PDLP1 Localises to Haustoria-Associated Membranes during Downy Mildew Infection and Regulates Callose Deposition. PLoS Pathog. 2014 Nov 13;10(11):e1004496. doi: 10.1371/journal.ppat.1004496.

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Hofberger JA, Zhou B, Tang H, Jones JD, Schranz ME (2014)

A novel approach for multi-domain and multi-gene family identification provides insights into evolutionary dynamics of disease resistance genes in core eudicot plants. BMC Genomics. 2014 Nov 8;15:966. doi: 10.1186/1471-2164-15-966.

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Sohn et al (2014)

Sohn KH, Segonzac C, Rallapalli G, Sarris PF, Woo JY, Williams SJ, Newman TE, Paek KH, Kobe B, Jones JD (2014)

The Nuclear Immune Receptor RPS4 Is Required for RRS1SLH1-Dependent Constitutive Defense Activation in Arabidopsis thaliana. PLoS Genet. 2014 Oct 23;10(10):e1004655. doi: 10.1371/journal.pgen.1004655

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