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Professor Stephen Bornemann

Director of Postgraduate Research and Training
Administration

I lead the training of postgraduate researchers at TSL. I coordinate and help deliver face-to-face and online activities with pre-doctoral interns through to early career researchers. New developments will include an MSc in Global Plant Protection and an associated massive open online course (MOOC) in Global Challenges in Plant Pathology.

Stephen.Bornemann@tsl.ac.uk
Research ID: K-2938-2012
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Publications

Syson K, Batey SFD, Schindler S, Kalscheuer R, Bornemann S (2020)

A temperature-sensitive Mycobacterium smegmatis glgE mutation leads to a loss of GlgE enzyme activity and thermostability and the accumulation of α-maltose-1-phosphate. Biochim Biophys Acta Gen Subj. 2020 Nov 6:129783. doi: 10.1016/j.bbagen.2020.129783.

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Woodcock SD, Syson K, Little RH, Sifouna D, Brown JKM, Bornemann S, Malone JG (2020)

Trehalose and α-glucan mediate distinct abiotic stress responses in Pseudomonas aeruginosa. bioRxiv preprint Oct 23, 2020 doi: https://doi.org/10.1101/2020.10.23.351924

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Syson K, Batey SFD, Schindler S, Kalscheuer R, Bornemann S (2020)

The molecular basis for a temperature-sensitive Mycobacterium smegmatis glgE mutant. bioRxiv preprint Apr 23, 2020 doi: https://doi.org/10.1101/2020.04.23.057067

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Koliwer-Brandl H, Syson K, van de Weerd R, Chandra G, Appelmelk B, Alber M, Ioerger TR, Jacobs WR Jr, Geurtsen J, Bornemann S, Kalscheuer R (2016)

Metabolic network for the biosynthesis of intra- and extracellular α-glucans required for virulence of Mycobacterium tuberculosis. PLoS Pathog 12, e1005768. http://doi.org/10.1371/JOURNAL.PPAT.1005768

Rashid AM, Batey SF, Syson K, Koliwer-Brandl H, Miah F, Barclay JE, Findlay KC, Nartowski KP, Khimyak YZ, Kalscheuer R, Bornemann S (2016)

Assembly of α-glucan by GlgE and GlgB in mycobacteria and streptomycetes. Biochemistry 55, 3270–3284. http://doi.org/10.1021/ACS.BIOCHEM.6B00209

Swainsbury DJ, Zhou L, Oldroyd GE, Bornemann S (2012)

Calcium ion binding properties of Medicago truncatula calcium/calmodulin-dependent protein kinase. Biochemistry 51, 6895-6907. http://doi.org/10.1021/BI300826M

Syson K, Stevenson CE, Rejzek M, Fairhurst SA, Nair A, Bruton CJ, Field RA, Chater KF, Lawson DM, Bornemann S (2011)

Structure of a Streptomyces maltosyltransferase GlgE: a homologue of a genetically validated anti-tuberculosis target. J Biol Chem. 286, 38298-38310. http://doi.org/10.1074/JBC.M111.279315

Kalscheuer R, Syson K, Veeraraghavan U, Weinrick B, Biermann KE, Liu Z, Sacchettini JC, Besra G, Bornemann S, Jacobs WR Jr (2010)

Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an α-glucan pathway. Nature Chem Biol 6, 376-384. http://doi.org/10.1038/NCHEMBIO.340

Requena L, Bornemann S (1999)

Barley (Hordeum vulgare) oxalate oxidase is a manganese-containing enzyme. Biochem J 343, 185-190. http://doi.org/10.1042/0264-6021:3430185

Job History

2020 – present Director of Postgraduate Research and Training, The Sainsbury Laboratory, Norwich, UK

2017 – 2020 Postgraduate Research Director, John Innes Centre, Norwich, UK

1996 – 2017 Group Leader, John Innes Centre, Norwich, UK

1992 – 1995 Postdoc, Nitrogen Fixation Laboratory, Sussex University, UK

1989 – 1992 PhD Chemistry, Warwick University, UK

1987 – 1989 Research Scientist, Tate & Lyle Research & Technology, Reading University, UK

1986 – 1987 MSc Biotechnology, University College London, UK

1983 – 1986 BSc Biochemistry, King’s College London, UK