Steuernagel B, Jupe F, Witek K, Jones JD, Wulff BB (2015)
NLR-parser: Rapid annotation of plant NLR complements. Bioinformatics. 2015 Jan 12. pii: btv005. [Epub ahead of print]Read more
My group is interested in how plants resist disease, and in how resistance is overcome by pathogens. To suppress host defence, pathogens secrete effector proteins into plant cells or into their apoplastic spaces. How these effectors work, and the identity of their targets in the host, help us understand plant defence mechanisms.
We work on the following problems.
NLR-parser: Rapid annotation of plant NLR complements. Bioinformatics. 2015 Jan 12. pii: btv005. [Epub ahead of print]Read more
The Plasmodesmal Protein PDLP1 Localises to Haustoria-Associated Membranes during Downy Mildew Infection and Regulates Callose Deposition. PLoS Pathog. 2014 Nov 13;10(11):e1004496. doi: 10.1371/journal.ppat.1004496.Read more
A novel approach for multi-domain and multi-gene family identification provides insights into evolutionary dynamics of disease resistance genes in core eudicot plants. BMC Genomics. 2014 Nov 8;15:966. doi: 10.1186/1471-2164-15-966.Read more
The Nuclear Immune Receptor RPS4 Is Required for RRS1SLH1-Dependent Constitutive Defense Activation in Arabidopsis thaliana. PLoS Genet. 2014 Oct 23;10(10):e1004655. doi: 10.1371/journal.pgen.1004655Read more
Expression Profiling during Arabidopsis/Downy Mildew Interaction Reveals a Highly-Expressed Effector That Attenuates Responses to Salicylic Acid. PLoS Pathog 10(10): e1004443. doi:10.1371/journal.ppat.1004443Read more
Probing formation of cargo/importin-α transport complexes in plant cells using a pathogen effector. Plant Journal (2014) doi: 10.1111/tpj.12691Read more
Convergent Targeting of a Common Host Protein-Network by Pathogen Effectors from Three Kingdoms of Life. Cell Host & Microbe 16: 364 – 375 (2014) DOI: http://dx.doi.org/10.1016/j.chom.2014.08.004Read more
The Top 10 oomycete pathogens in molecular plant pathology. Mol Plant Pathol. 2014 Sep 1. doi: 10.1111/mpp.12190. [Epub ahead of print] PubMed PMID: 25178392.Read more
Identification of unique SUN-interacting nuclear envelope proteins with diverse functions in plants. J Cell Biol. 2014 Jun 9;205(5):677-92.
Exprss: an illumina based high-throughput expression-profiling method to reveal transcriptional dynamics. BMC Genomics, 15(1):341Read more
Defining the full tomato NB-LRR resistance gene repertoire using genomic and cDNA RenSeq. BMC Plant Biology 2014, 14:120 doi:10.1186/1471-2229-14-120Read more
Genomic DNA Library Preparation for Resistance Gene Enrichment and Sequencing (RenSeq) in Plants. Methods in Molecular Biology. (Clifton, N.J.) 1127:291-303.
Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor. SCIENCE, 344(6181):299-303.
Direct regulation of the NADPH oxidase RBOHD by the PRR-associated kinase BIK1 during plant immunity. Molecular Cell, 54 (1): 43-55.Read more
Elevating crop disease resistance with cloned genes. Philosophical Transactions of the Royal Society B 369 20130087Read more
In planta effector competition assays detect Hyaloperonospora arabidopsidis effectors that contribute to virulence and localize to different plant subcellular compartments. Mol Plant Microbe Interact 26: 745-757.
A downy mildew effector attenuates salicylic Acid-triggered immunity in Arabidopsis by interacting with the host mediator complex. PLoS Biol 11: e1001732
Resistance gene enrichment sequencing (renseq) enables reannotation of the nb-lrr gene family from sequenced plant genomes and rapid mapping of resistance loci in segregating populations. The Plant Journal, 76(3):530–544
The variable domain of a plant calcium-dependent protein kinase (CDPK) confers subcellular localization and substrate recognition for NADPH oxidase. JBC, 288(20):14332-14340.
Identifying and classifying trait linked polymorphisms in non-reference species by walking coloured de bruijn graphs. PloS ONE, 8(3):e60058
Mechanisms of Nuclear Suppression of Host Immunity by Effectors from the Arabidopsis Downy Mildew Pathogen Hyaloperonospora arabidopsidis (Hpa). Cold Spring Harb Symp Quant Biol. 2012 Dec 4.
Distinct regions of the Pseudomonas syringae coiled-coil effector AvrRps4 are required for activation of immunity. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16371-6. doi: 10.1073/pnas.1212332109. Epub 2012 Sep 17
Draft genome sequence of Pseudomonas syringae pathovar syringae strain FF5, causal agent of stem tip dieback disease on ornamental pear. J Bacteriol. 2012 Jul;194(14):3733-4. doi: 10.1128/JB.00567-12.
The awr gene family encodes a novel class of Ralstonia solanacearum type III effectors displaying virulence and avirulence activities. Mol Plant Microbe Interact. 2012 Jul;25(7):941-53. doi: 10.1094/MPMI-12-11-0321.
Obligate biotroph parasitism: can we link genomes to lifestyles? Trends Plant Sci. 2012 Aug;17(8):448-57. doi: 10.1016/j.tplants.2012.04.005. Epub 2012 May 19
Coverage-based consensus calling (CbCC) of short sequence reads and comparison of CbCC results to identify SNPs in chickpea (Cicer arietinum; Fabaceae), a crop species without a reference genome. Am J Bot. 2012 Feb;99(2):186-92. doi: 10.3732/ajb.1100419. Epub 2012 Feb 1.
Molecular cloning of ATR5(Emoy2) from Hyaloperonospora arabidopsidis, an avirulence determinant that triggers RPP5-mediated defense in Arabidopsis. Mol Plant Microbe Interact 24, 827-838.
Identification and localisation of the NB-LRR gene family within the potato genome. BMC Genomics 15;13:75.
Characterization of the membrane-associated HaRxL17 Hpa effector candidate. Plant Signal Behav. 2012 Jan;7(1):145-9. doi: 10.4161/psb.7.1.18450.
Subcellular localization of the Hpa RxLR effector repertoire identifies a tonoplast-associated protein HaRxL17 that confers enhanced plant susceptibility. Plant J. 2012 Jan;69(2):252-65. doi: 10.1111/j.1365-313X.2011.04787.x. Epub 2011 Nov 29.
Multiple candidate effectors from the oomycete pathogen Hyaloperonospora arabidopsidis suppress host plant immunity. PLOS Pathogens e1002348
Crystallization and preliminary X-ray diffraction analysis of the RxLR-type effector RxLR3 from the oomycete pathogen Hyaloperonospora arabidopsidis (2011). Acta Crystallogr Sect F Struct Biol Cryst Commun. 67(Pt 11):1417-20.
One hundred important questions facing plant science research (2011) New Phytol. 192(1):6-12.
Hormone crosstalk in plant disease and defense: more than just salicylate/jasmonate antagonism Annu Rev Phytopathol. 2011 49:317-43.
Gene gain and loss during evolution of obligate parasitism in the white rust pathogen of arabidopsis thaliana. PLoS Biology, 9(7):e1001094
Subcellular localization of the Hpa effector repertoire identifies a tonoplast-associated protein, HaRxL17, that confers enhanced host susceptibility Plant J. (in press).
The microrna mir393 re-directs secondary metabolite biosynthesis away from camalexin and towards glucosinolates. The Plant Journal, 67(2):218–231
Why genetically modified crops? Philos Transact A Math Phys Eng Sci. May 13;369(1942):1807-16. PubMed PMID: 21464072.
Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome. Science, 330:1549-1551.Read more
Genome-wide sequencing data reveals virulence factors implicated in banana xanthomonas wilt. FEMS Microbiology Letters, 310(2):182–192.
Genome-wide survey of Arabidopsis natural variation in downy mildew resistance using combined association and linkage mapping. Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10302-7. Epub 2010 May 17. PubMed PMID: 20479233; PubMed Central PMCID: PMC2890483.
Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Nature. 2010 Jun 3;465(7298):627-31. Epub 2010 Mar 24. PubMed PMID: 20336072.
Inter-family transfer of a plant pattern recognition receptor confers broad-spectrum bacterial resistance. Nature Biotechnology, 4 :365-369.
Regions of the Cf-9B disease resistance protein able to cause spontaneous necrosis in Nicotiana benthamiana lie within the region controlling pathogen recognition in tomato. Mol Plant Microbe Interact. 2009 Oct;22(10):1214-26. PubMed PMID: 19737095.
The major specificity-determining amino acids of the tomato Cf-9 disease resistance protein are at hypervariable solvent-exposed positions in the central leucine-rich repeats. Mol Plant Microbe Interact. 2009 Oct;22(10):1203-13. PubMed PMID: 19737094.
Control of the pattern recognition receptor EFR by an ER protein complex in plant immunity. EMBO Journal 28: 3428-3438.
A dedicated subset of ER quality control components required for plant innate immunity. Proc. Natl. Acad. Sci. USA 106: 15973-15978.
Specific ER quality control components required for biogenesis of the plant innate immune receptor EFR. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15973-8. Epub 2009 Aug 26. PubMed PMID: 19717464; PubMed Central PMCID: PMC2747228.
Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans. Nature 461:393-398.Read more
Mapping and cloning of late blight resistance genes from Solanum venturii using an interspecific candidate gene approach. Molecular Plant-Microbe Interactions 22:601-615.
A draft genome sequence of Pseudomonas syringae pv. tomato T1 reveals a type III effector repertoire significantly divergent from that of Pseudomonas syringae pv. tomato DC3000. Mol Plant Microbe Interact. 2009 Jan;22(1):52-62. PubMed PMID: 19061402.
A new species of Albugo parasitic to Arabidopsis thaliana reveals new evolutionary patterns in white blister rusts (Albuginaceae). Persoonia. 2009 Jun;22:123-8. Epub 2009 May 26. PubMed PMID: 20198144; PubMed Central PMCID: PMC2789544.
Autophagic components contribute to hypersensitive cell death in Arabidopsis. Cell. 2009 May 15;137(4):773-83. PubMed PMID: 19450522.
Hormone (dis)harmony moulds plant health and disease. Science. 2009 May 8;324(5928):750-2. PubMed PMID: 19423816.
Rpi-vnt1.1, a TM-22 homology from Solanum venturii, confers resistance to potato late blight. Molecular Plant-Microbe Interactions 22:589-600.
Role of plant hormones in plant defence responses. Plant Mol Biol. 2009 Mar;69(4):473-88. Epub 2008 Dec 16. Review. PubMed PMID: 19083153.
The Pseudomonas syringae effector protein, AvrRPS4, requires in planta processing and the KRVY domain to function. Plant J. 2009 Mar;57(6):1079-91. Epub 2009 Jan 17. PubMed PMID: 19054367.
The TIR domain of TIR-NB-LRR resistance proteins is a signaling domain involved in cell death induction. Mol Plant Microbe Interact. 2009 Feb;22(2):157-65. PubMed PMID: 19132868.
Application of ’next-generation’ sequencing technologies to microbial genetics. Nature Reviews Microbiology, 7(4):287–296
Two distinct potato late blight resistance genes from Solanum berthaultii are located on chromosome 10. Euphytica 165:269-278.
Characterization of Arabidopsis mur3 mutations that result in constitutive activation of defence in petioles, but not leaves. Plant J. 2008 Dec;56(5):691-703. Epub 2008 Jul 23. PubMed PMID: 18657237.
The auxin influx carrier LAX3 promotes lateral root emergence. Nat Cell Biol. 2008 Aug;10(8):946-54. Epub 2008 Jul 11. PubMed PMID: 18622388.
A genome-wide functional investigation into the roles of receptor-like proteins in Arabidopsis. Plant Physiology 147(2): 503-17.
DELLAs control plant immune responses by modulating the balance of jasmonic acid and salicylic acid signaling. Curr Biol. 2008 May 6;18(9):650-5. PubMed PMID: 18450451.
Genetic analysis of PAMP-triggered immunity in Arabidopsis. In: Lorito, M, Woo, SL and Scala, F (ed). International Society for Molecular Plant-Microbe Interactions, St. Paul, Minnesota. Biology of Plant-Microbe Interactions, 6.
The f-box protein acre189/acif1 regulates cell death and defense responses activated during pathogen recognition in tobacco and tomato. The Plant Cell Online, 20(3):697–719
Plant pathogen effectors: getting mixed messages. Curr Biol. 2008 Feb 12;18(3):R128-30. PubMed PMID: 18269910.
Induction of phenotypic variation by activation of genes harbouring a maize Spm element in their promoter regions using a TnpA-VP16 fusion protein. Plant J. 2008 Feb;53(3):587-94. Epub 2007 Dec 6. PubMed PMID: 18069940.
The downy mildew effector proteins ATR1 and ATR13 promote disease susceptibility in Arabidopsis thaliana. Plant Cell. 2007 Dec;19(12):4077-90. PubMed PMID: 18165328; PubMed Central PMCID: PMC2217653.
Nuclear accumulation of the Arabidopsis immune receptor RPS4 is necessary for triggering EDS1-dependent defense. Curr Biol. 2007 Dec 4;17(23):2023-9. PubMed PMID: 17997306.
Marker development for the genetic study of natural variation in Arabidopsis thaliana. Bioinformatics. Nov 15;23(22):3108-9. PubMed PMID: 18025007.
Molecular analysis of Agrobacterium T-DNA integration in tomato reveals a role for left border sequence homology in most integration events. Mol Genet Genomics. Oct;278(4):411-20. Epub 2007 Jun 16. PubMed PMID: 17574477.
Pathological hormone imbalances. Curr Opin Plant Biol. 2007 Aug;10(4):372-9. Review. PubMed PMID: 17646123.
Genome-wide patterns of single-feature polymorphism in Arabidopsis thaliana. Proc Natl Acad Sci U S A. Jul 17;104(29):12057-62. Epub 2007 Jul 12. PubMed PMID: 17626786; PubMed Central PMCID: PMC1914337.
A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence. Nature, 448: 497-500.
Inducible cell death in plant immunity. Semin Cancer Biol. Apr;17(2):166-87. Epub 2006 Dec 12. PubMed PMID: 17218111.
The plant immune system. Nature. 444:323-9.
Multiple Avirulence Gene Paralogues in the Cereal Powdery Mildew Fungi. Plant Cell 2006, 18:2402-14.
A Bacterial Virulence Protein Suppresses Host Innate Immunity to Cause Plant Disease. Science 313:220-3
The Arabidopsis thaliana TIR-NB-LRR R protein, RPP1A; protein localization and constitutive activation of defence by truncated alleles in tobacco and Arabidopsis. Plant Journal 47:829-840
CITRX thioredoxin is a putative adaptor protein connecting Cf-9 and the ACIK1 protein kinase during the Cf-9/Avr9- induced defence response. FEBS Letters 580(17):4236-41
Reactive Oxygen Species Signaling in Response to Pathogens Plant Physiol. 141 373-378
Perception of the bacterial PAMP EF-Tu by the receptor EFR restricts Agrobacterium-mediated transformation. Cell, 125: 749-760.
A Plant MicroRNA Confers Bacterial Disease Resistance By Repressing Auxin Signaling Science. 312 436-439
Dominant-negative interference with defence signalling by truncation mutations of the tomato Cf-9 disease resistance gene. The Plant Journal 46(3) 385-399
A tomato mutant that shows stunting, wilting, progressive necrosis and constitutive expression of defence genes contains a recombinant Hcr9 gene encoding an autoactive protein. The Plant Journal, 46(3) 369-384
The U-box Protein CMPG1 is Required for Efficient Activation of Defense Mechanisms Triggered by Multiple Resistance Genes in Tobacco and Tomato Plant Cell, 18:1067-1083.
Rewiring mitogen-activated protein kinase cascade by positive feedback confers potato blight resistance. Plant Physiology 140 (2) 681-692.
The U-box protein AtPUB17 is a functional ortholog of NtACRE276 and its E3 ubiquitin ligase activity is required for cell death and defence Plant Cell 18:1084-1098
Involvement of PPS3 phosphorylated by elicitor-responsive mitogen-activated protein kinases in the regulation of plant cell death. Plant Physiology 139(4) 1914-1926
Solanum mochiquense chromosome IX carries a novel late blight resistance gene Rpi-moc1 Theor. Appl. Genetics 110: 252-8.
Pathogen-induced, NADPH oxidase-derived reactive oxygen intermediates suppress spread of cell death in Arabidopsis thaliana. Nat Genet. 37:1130-4.
Rapid Phosphorylation of a Syntaxin during the Avr9/Cf-9-Race-Specific Signalling Pathway Plant Phys 138: 2406-2416.
Phylogenomic analysis of the receptor-like proteins of rice and Arabidopsis Plant Phys 138: 611-623.
Ethylene-mediated cross-talk between calcium-dependent protein kinase and MAPK signaling controls stress responses in plants PNAS 102 10736-10741.
Cladosporium Avr2 Inhibits Tomato Rcr3 Protease Required for Cf-2-Dependent Disease Resistance Science 308: 1783-6.
Structure-function analysis of Cf-9, a receptor-like protein with extracytoplasmic leucine-rich repeats. Plant Cell. 17:1000-15.
Patterns of Dwarf expression and brassinosteroid accumulation in tomato reveal the importance of brassinosteroid synthesis during fruit development, Plant Journal 42, 262.269.
Functional Analysis of Avr9/Cf-9 Rapidly Elicited Genes Identifies a Protein Kinase, ACIK1, That Is Essential for Full Cf-9-Dependent Disease Resistance in Tomato. Plant Cell. 17:295-310.
Gene shuffling-generated and natural variants of the tomato resistance gene Cf-9 exhibit different auto-necrosis-inducing activities in Nicotiana species. Plant J. Dec;40(6):942-56.
Ac Transposase Induces Methylation of a Ds Transposon in Transgenic Tomato Journal of Genome Science and Technology 3, 27-29.
Arabidopsis downy mildew resistance gene RPP27 encodes a receptor-like protein similar to CLV2 and tomato Cf-9. Plant Phys 135:1100-1112.
The plant proteolytic machinery and its role in defence. Curr Opin Plant Biol. Aug;7(4):400-7.
Expression of RPS4 in tobacco induces an AvrRps4-independent HR that requires EDS1, SGT1 and HSP90. Plant J. Oct;40(2):213-24.
CITRX thioredoxin interacts with the tomato Cf-9 resistance protein and negatively regulates defence. EMBO Journal, 23(10): 2156-2165
Virus-Induced Gene Silencing in Solanum Species Plant Journal 39:264-272.
Bacterial disease resistance through flagellin perception in Arabidopsis. Nature, 428: 764-767.
Genetic variation at the tomato Cf-4/Cf-9 locus induced by EMS mutagenesis and intra-locus recombination. Genetics . 167: 459-470.
NADPH oxidase AtrbohD and AtrbohF genes function in ROS-dependent ABA signalling in Arabidopsis EMBO J. 2003 Jun 2;22(11):2623-33.
Reactive oxygen species produced by NADPH oxidase regulate plant cell growth Nature 422 442-6
Rapid migration in gel filtration of the Cf-4 and Cf-9 resistance proteins is an intrinsic property of Cf proteins and not due to their association with high molecular weight proteins. Plant J. 2003 Aug;35(3):305-15.
Nicotiana benthamiana gp91phox Homologs NbrbohA and NbrbohB Participate in H2O2 Accumulation and Resistance to Phytophthora infestans Plant Cell 15: 706-718.
Multi-functional T-DNA/Ds tomato lines designed for gene cloning and molecular and physical dissection of the tomato genome. Plant Molecular Biology 51 83-98
Arabidopsis RAR1 exerts rate-limiting control of R gene-mediated defences against multiple pathogens Plant Cell 14 979-992.
Ubiquitin ligase-associated protein SGT1 is required for host and nonhost disease resistance in plants. Proc Natl Acad Sci U S A. ;99:10865-9.
A ~400 kDa membrane-associated complex that contains one molecule of the resistance protein Cf-4. Plant Journal 29 783-796.
A tomato cysteine protease required for cf-2- dependent disease resistance and supression of autonecrosis. Science 296 744-747
Regulatory Role of SGT1 in Early R Gene-Mediated Plant Defenses. Science 295 2077-2080.
The Cf-9 disease resistance protein is present in a ~420 kDa heteromultimeric membrane-associated complex at one molecule per complex. Plant Cell 14: 689-702.
From physics and chemistry to plant biology. Plant Physiol. 2002 Feb;128(2):332-3.
Arabidopsis gp91phox homologues AtrbohD and AtrbohF are required for accumulation of reactive oxygen intermediates in the plant defense response Proc.Natl.Acad.Sci.USA 99 517-522.
Arabidopsis RPP4 is a Member of the RPP5 Multigene Family of TIR-NB-LRR genes and Confers Downy Mildew Resistance Through Multiple Signaling Components. Plant Journal 29 439-451.
Calcium-Dependent Protein Kinases Play an Essential Role in a Plant Defence Response EMBO J 20 5556-5567.
Domain swapping and gene shuffling identify sequences required for induction of an Avr-dependent hypersensitive response by the tomato Cf-4 and Cf-9 proteins. Plant Cell 13 255-272
Plant pathogens and integrated defence responses to infection. Nature 411, 826-833.
No evidence for binding between resistance gene product Cf-9 of tomato and avirulence gene product AVR9 of Cladosporium fulvum. Molecular Plant-Microbe Interactions 14, 867-876.
Putting knowledge of plant disease resistance genes to work. Current Opinion in Plant Biology 4, 281-287.
Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in Arabidopsis. EMBO J. 2000 Nov 15;19(22):6150-61.
Genetic complexity of pathogen perception by plants: The example of Rcr3, a tomato gene required specifically by Cf-2. Proc Nat Acad Sci USA 97, 8807-8813.
cDNA-AFLP reveals a striking overlap in race-specific resistance and wound response gene expression profiles. Plant Cell 12, 963- 977.
Resistance gene-dependent activation of a calcium-dependent protein kinase (CDPK) in the plant defence response. Plant Cell 12, 803-815.
Salicylic acid is not required for Cf-2- and Cf-9-dependent resistance of tomato to Cladosporium fulvum. Plant Journal 23, 305-318.
Functional, c-myc-tagged Cf-9 resistance gene products are plasma membrane localised and glycosylated. The Plant Journal 21, 529-536.
Arabidopsis RelA/SpoT homologs implicat (p)ppGpp in plant signalling. Proc.Natl.Acad.Sci.USA 97. 3747- 3752.
Multiple independent defective Suppressor-mutator transposon insertions in Arabidopsis: A tool for functional genomics. Plant Cell 11, 1841-1852.
A second gene at the tomato Cf-4 locus confers resistance to Cladosporium fulvum through recognition of a novel avirulence determinant. Plant Journal 20 279-288.
Pronounced Intraspecific Haplotype Divergence at the RPP5 Complex Disease Resistance Locus in Arabidopsis. Plant Cell 11, 2099-2012.
Recombination between diverged clusters of the tomato Cf-9 plant disease resistance gene family. Proc Nat Acad Sci USA 96, 5850-5855
EDS1, an essential component of R gene-mediated disease resistance in Arabidopsis has homology to eukaryotic lipases. .. Proc Nat Acad Sci USA 96, 3292-3297.
Rapid Avr 9- and Cf-9 .Dependent Activation of MAP Kinases in Tobacco Cell Cultures and Leaves: Convergence of Resistance Gene, Elicitor, Wound, and Salicylate Responses The Plant Cell 11: 273-288.
Homologues of the Cf-9 disease resistance gene (Hcr9s) are present at multiple loci on the short arm of tomato chromosome 1. Molecular Plant-Microbe Interactions 12, 93-102.
Plant disease-resistance proteins and the gene-for-gene concept. Trends in Biochemical Sciences 23, 454-456.
Three genes of the Arabidopsis RPP1 complex resistance locus recognize distinct Peronospora parasitica avirulence determinants. The Plant Cell 10, 1847-1860
The NB-ARC domain: A novel signalling motif shared by plant resistance gene products and regulators of cell death in animals. Current Biology 8, R226-R22
Six Arabidopsis thaliana homologues of the human respiratory burst oxidase (gp91phox) Plant Journal 14 365-370
Rapid, Cf-9- and Avr9-dependent production of active oxygen species in tobacco suspension cultures. Molecular Plant-Microbe Interactions 11, 1155-1166.
The tomato Cf-9 disease resistance gene functions in tobacco and potato to confer responsiveness to the fungal avirulence gene product Avr9. The Plant Cell 10, 1251-1266.
Transposon tagging of the Defective embryo and meristems gene of tomato. The Plant Cell 10, 877-887.
Epigenetic instability and trans- silencing interactions associated with an SPT::Ac T-DNA locus in tobacco: Genetics 148, 457-469
Characterization of the tomato Cf-4 gene for resistance to Cladosporium fulvum identifies a domain which determines recognitional specificity in Cf-4 and Cf-9: The Plant Cell 9, 2209-2224.
Novel Disease Resistance Specificities Result From Sequence Exchange Between Tandemly Repeated Genes At The Cf-4/9 Locus Of Tomato: Cell 91, 821-832.
The Arabidopsis Downy Mildew Resistance Gene RPP5 Shares Similarity to the Toll and Interleukin-1 Receptors with N and L6.: The Plant Cell, v. 9, p. 879-894
AtDMC1, the Arabidopsis homolog of the yeast DMC1 gene: characterization, transposon-induced allelic variation and meiosis-associated expression: The Plant Journal, 11, p. 1-14.
The roles of leucine-rich repeat proteins in plant defences. Advances in Botanical Research incorporating Advances in Plant Pathology. 24 89 . 167
Plant Disease Resistance Genes: Ann. Rev. Plant Physiol. Plant Mol. Biol., v. 48, p. 575-607.
Resistance gene-dependent plant defense responses.: The Plant Cell, 8, p. 1773-1791.
The tomato dwarf gene isolated by heterologous transposon tagging encodes the first member of a new cytochrome P450 family. The Plant Cell 8 959-969
The DCL gene of tomato is required for chloroplast development and palisade cell morphogenesis in leaves. EMBO J. 15 4208 . 4217
The tomato Cf-2 disease resistance locus comprises two functional genes encoding leucine-rich repeat proteins. Cell 84,451-459.
Race-specific elicitors of Cladosporium fulvum induce changes in cell morphology and the synthesis of ethylene and salicylic acid in tomato plants carrying the corresponding Cf disease resistance genes. Plant Physiol. 110,1381-1394.
Involvement of reactive oxygen species, glutathione metabolism, and lipid peroxidation in the Cf-gene-dependent defense response of tomato cotyledons induced by race-specific elicitors of Cladosporium fulvum. Plant Physiol. 110,1367-1379.
Molecular genetics of plant disease resistance. Science 268,661-667.
Aberrant transpositions of maize double Ds-like elements involve Ds on sister chromatids. The Plant Cell 7, 1235 – 1247
Patterns of gene action in plant development revealed by enhancer trap and gene trap transposable elements. Genes Dev. 9,1797-1810.
Developmentally regulated cell death on expression of the fungal avirulence gene Avr9 in tomato seedlings carrying the disease resistance gene Cf-9. Proc Nat Acad Sci USA 91,10445-10449.
Identification of two genes required in tomato for full Cf-9-dependent resistance to Cladosporium fulvum. The Plant Cell 6,361-374.
Incomplete dominance of tomato Cf genes for resistance to Cladosporium fulvum . Molecular Plant-Microbe Interactions. 7: 58-70.
Isolation of the tomato Cf-9 gene for resistance to Cladosporium fulvum by transposon tagging. Science (Wash.). 266,789-793.
High level expression of the Activator transposase gene inhibits the excision of Dissociation in tobacco cotyledons. Cell 75,507-517.
Close Linkage Between the Cf-2/Cf-5 and Mi Resistance Loci in Tomato.. Molecular Plant-Microbe Interactions 6(3): 341-347.
Heterologous transposon tagging of the DRL1 locus in Arabiodopsis. . The Plant Cell 5,631-638.
A genetic analysis of DNA sequence requirements for Dissociation State I activity in tobacco. The Plant Cell 5,501-514.
Effective vectors for transformation, expression of heterologous genes, and assaying transposon excision in transgenic plants.. Transgenic Research 1: 285-297.
Promoter fusions to the Ac transposase gene confer distinct patterns of Ds somatic and germinal excision in tobacco: The Plant Cell, 4, p. 573-582.
Preferential transposition of the maize element Activator to linked chromosomal locations in tobacco: The Plant Cell, 2, p. 701-707.
Influence of flanking sequences on variability in expression levels of an introduced gene in transgenic tobacco plants.. Nucleic Acids Research 16: 9267-9284.