Our exciting projects range from genomics through bioinformatics and citizen science to evolutionary modeling. We bring together biology, computational science and bioinformatics to make the most of big data and help answer big questions.
We study data from citizen science projects to understand how the ‘crowd’ can be used as a super-intelligent computer.
We develop tools and methods to make the most of high throughput sequence data to study non-reference, non-model organisms
We use mathematical modelling techniques to understand what drives genome size and the dynamics of gene regulation.
Furzer OJ, Cevik V, Fairhead S, Bailey K, Redkar A, Schudoma C, MacLean D, Holub EB, Jones JDG (2021)
An improved assembly of the Albugo candida Ac2V genome reveals the expansion of the “CCG” class of effectors. bioRxiv preprint Mar 29, 2021 doi: https://doi.org/10.1101/2021.03.29.437041Read more
Derevnina L, Contreras MP, Adachi H, Upson J, Cruces AV, Xie R, Sklenar J, Menke FLH, Mugford ST, MacLean D, Ma W, Hogenhout SA, Goverse A, Maqbool A, Wu CH, Kamoun S (2021)
Plant pathogens convergently evolved to counteract redundant nodes of an NLR immune receptor network. bioRxiv preprint Feb 03, 2021 doi: https://doi.org/10.1101/2021.02.03.429184Read more
Derkacheva M, Yu G, Rufian JS, Jiang S, Derbyshire P, Morcillo R, Stransfeld L, Wei Y, Menke F, Zipfel C, Macho A (2020)
The Arabidopsis E3 ubiquitin ligase PUB4 regulates BIK1 homeostasis and is targeted by a bacterial type-III effector. bioRxiv preprint Oct 26, 2020 doi: https://doi.org/10.1101/2020.10.25.354514Read more
Thor K, Jiang S, Michard E, George J, Scherzer S, Huang S, Dindas J, Derbyshire P, Leitão N, DeFalco TA, Köster P, Hunter K, Kimura S, Gronnier J, Stransfeld L, Kadota Y, Bücherl CA, Charpentier M, Wrzaczek M, MacLean D, Oldroyd GED, Menke FLH, M. Roelfsema MRG, Hedrich R, Feijó J, Zipfel C (2020)
The calcium-permeable channel OSCA1.3 regulates plant stomatal immunity. Nature. 25 August 2020. DOI: 10.1038/s41586-020-2702-1Read more