Our exciting projects range from genomics through bioinformatics and citizen science to evolutionary modeling. We bring together biology, computational science and bioinformatics to make the most of big data and help answer big questions.
We study data from citizen science projects to understand how the ‘crowd’ can be used as a super-intelligent computer.
We develop tools and methods to make the most of high throughput sequence data to study non-reference, non-model organisms
We use mathematical modelling techniques to understand what drives genome size and the dynamics of gene regulation.
Derkacheva M, Yu G, Rufian JS, Jiang S, Derbyshire P, Morcillo R, Stransfeld L, Wei Y, Menke F, Zipfel C, Macho A (2020)
The Arabidopsis E3 ubiquitin ligase PUB4 regulates BIK1 homeostasis and is targeted by a bacterial type-III effector. bioRxiv preprint Oct 26, 2020 doi: https://doi.org/10.1101/2020.10.25.354514Read more
Thor K, Jiang S, Michard E, George J, Scherzer S, Huang S, Dindas J, Derbyshire P, Leitão N, DeFalco TA, Köster P, Hunter K, Kimura S, Gronnier J, Stransfeld L, Kadota Y, Bücherl CA, Charpentier M, Wrzaczek M, MacLean D, Oldroyd GED, Menke FLH, M. Roelfsema MRG, Hedrich R, Feijó J, Zipfel C (2020)
The calcium-permeable channel OSCA1.3 regulates plant stomatal immunity. Nature. 25 August 2020. DOI: 10.1038/s41586-020-2702-1Read more
Kristianingsih R, MacLean D (2020)
Accurate plant pathogen effector protein classification ab initio with deepredeff, an ensemble of convolutional neural networks. bioRxiv preprint July 09, 2020 doi: https://doi.org/10.1101/2020.07.08.193250Read more
Ding P, Sakai T, Shrestha RK, Perez NM, Guo W, Ngou BPM, He S, Liu C, Feng X, Zhang R, Vandepoele K, MacLean D, Jones JDG (2020)
Chromatin accessibility landscapes activated by cell surface and intracellular immune receptors. bioRxiv preprint June 18, 2020 doi: https://doi.org/10.1101/2020.06.17.157040Read more