TSL partners with 2Blades Foundation and J.R. Simplot Company to develop resistance against potato diseases

  • Published:
Cyril Zipfel, Head of TSL
Cyril Zipfel, Head of TSL

The Sainsbury Laboratory will work as part of a research partnership with the Two Blades Foundation (2Blades) and J. R. Simplot Company to develop potato varieties with increased resistance to oomycete and bacterial diseases.

Late blight, the oomycete disease that resulted in the Irish Potato Famine, is the most notorious of potato diseases and still a significant cause of yield loss in potato production today. The late blight pathogen, Phytophthora infestans, can also cause tuber rot.

To identify long lasting resistance to late blight, scientists and breeders have turned to wild relatives of potato to identify resistance genes and introduce these into agronomic varieties. The current partnership aims to explore new sources of late blight resistance identified in the laboratory of Prof. Jonathan Jones at The Sainsbury Laboratory in Norwich, U.K.

Simplot has recently received USDA and FDA clearance for its second generation Innate® potatoes with late blight disease resistance for common North American strains. The partnership with 2Blades and The Sainsbury Laboratory will enable Simplot to add additional genes from wild potato varieties to combat global strains in future Innate generations.

Potatoes are also susceptible to bacterial diseases, such as bacterial wilt and soft rot that can affect plants in the field and can lead to significant losses for stored potatoes. In addition to blight resistance, the new partnership will test the ability of the EFR gene, a broad-spectrum immune receptor that recognizes bacteria, to protect potatoes. The EFR gene is studied in the laboratory of Prof. Cyril Zipfel, Head of The Sainsbury Laboratory. EFR has already been demonstrated to confer resistance against bacterial diseases in tomato, tobacco, wheat, and other crops.

“The partnership with 2Blades and The Sainsbury Laboratory combines some of the most promising technology to combat devastating diseases with the popular commercial varieties of potatoes,” said Craig Richael, Director of Research and Development, Simplot Plant Sciences.

"The Sainsbury Laboratory is at the cutting edge of discovery in the field of plant-pathogen interactions," said Diana Horvath of 2Blades. “2Blades is pleased to advance the testing and deployment of Professors Jones and Zipfel’s discoveries by partnering with Simplot.”

Professor Jonathan Jones, TSL
Professor Jonathan Jones, TSL

About the Partners:

The Sainsbury Laboratory (TSL) is a world-leading research centre focusing on making fundamental discoveries about plants and how they interact with microbes. TSL not only provides fundamental biological insights into plant-pathogen interactions, but is also delivering novel, genomics-based, solutions which will significantly reduce losses from major diseases of food crops, especially in developing countries. TSL is an independent charitable company and receives strategic funding from the Gatsby Charitable Foundation with the balance coming from competitive grants and contracts from a range of public and private bodies, including the European Union (EU), Biotechnology and Biological Sciences Research Council (BBSRC) and commercial and charitable organisations www.tsl.ac.uk.

The Two Blades Foundation (www.2blades.org) is a 501(c)3 not-for-profit organization dedicated to discovering, advancing, and delivering genetic improvements in crop disease resistance.

The J.R. Simplot Company (www.simplot.com), is a privately held agribusiness firm headquartered in Boise, Idaho, with a Plant Sciences division responsible for Innate® Technology, an innovative biotechnology platform for improving potatoes.