My group’s research focuses on understanding the genetic architecture underlying nonhost resistance. We use natural and induced variation within nonhost species to identify the genetic loci specifying resistance.
Members of the group are based at TSL and at the USDA-ARS Cereal Disease Lab at the University of Minnesota, St. Paul. In addition to our own research, we collaborate with researchers across the Norwich Research Park.
Our efforts are concentrated on the cereal rusts and their interaction with several grass species, including wheat (Triticum aestivum), barley (Hordeum vulgare), oat (Avena sativa), and purple false brome (Brachypodium distachyon).
Our long-term goal is to identify and clone the molecular components underlying nonhost resistance and engineer this resistance in wheat. We apply a suite of approaches to rapidly accelerate our research, including genetics, bioinformatics, molecular biology, and next-generation sequencing.
Current projects in the group include:
– Genetic architecture underlying host species specificity of stripe rust
– Multiple pathogen resistance specificity at the Mla locus
– Map-based cloning of adult plant resistance QTLs to barley stripe rust
– Distribution, diversity, and expression of the barley NB-LRRome
– Nonhost resistance in Brachypodium spp. to wheat stripe rust
– Suppression of resistance in polyploid genomes
Group LeaderThe Sainsbury Laboratory, Norwich, UK
2013 - 2014
Team LeaderThe Sainsbury Laboratory, Norwich, UK
2010 - 2012
Research AssociateThe Sainsbury Laboratory, Norwich, UK
The blast effector Pwl2 is a virulence factor that modifies the cellular localisation of host protein HIPP43 to suppress immunity.