Mr Zane Duxbury

PhD Student
Jonathan Jones Group

I am working in Jonathan Jones’ group working on the paired Arabidopsis TIR-NB-LRR immune receptors RPS4 and RRS1. Our group discovered physical interactions and post-translational modifications between these receptors and their recognised effector proteins required for initiation of immune signalling. We are currently elucidating the specific mechanism for NB-LRR activation and effector recognition, and we are discovering roles for important cofactors. Elucidation of the RRS1/RPS4 recognition mechanism will help us to exploit this recognition strategy in order to engineer new receptors that recognise previously unrecognised and virulent pathogens.

Mr Zane Duxbury
+44 (0) 1603 450435


Huh SU, Cevik V, Ding P, Duxbury Z, Ma Y, Tomlinson L, Sarris PF, Jones JDG (2017)

Protein-protein interactions in the RPS4/RRS1 immune receptor complex. PLoS Pathog. 2017 May 5;13(5):e1006376. doi: 10.1371/journal.ppat.1006376.

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Duxbury Z, Ma Y, Furzer OJ, Huh SU, Cevik V, Jones JD, Sarris PF (2016)

Pathogen perception by NLRs in plants and animals: Parallel worlds. Bioessays. 2016 Jun 24. doi: 10.1002/bies.201600046.

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Trantas EA, Licciardello G, Almeida NF, Witek K, Strano CP, Duxbury Z, Ververidis F, Goumas DE, Jones JD, Guttman DS, Catara V, Sarris PF (2015)

Comparative genomic analysis of multiple strains of two unusual plant pathogens: Pseudomonas corrugata and Pseudomonas mediterranea. Front. Microbiol. | doi: 10.3389/fmicb.2015.00811

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Sarris PF, Duxbury Z, Huh SU, Yan Ma, Segonzac C, Sklenar J, Derbyshire P, Cevik V, Rallapalli G, Saucet SB, Wirthmueller L, Menke FLH, Sohn KH, Jones JDG

A plant immune receptor detects pathogen effectors that target WRKY transcription factors. Cell Volume 161, Issue 5, p1089–1100

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Skeffington AW, Graf A, Duxbury Z, Gruissem W, Smith AM. (2014)

Glucan, Water Dikinase Exerts Little Control over Starch Degradation in Arabidopsis Leaves at Night. Plant Physiol.165 (2), 866-879.

Lee JRM, Duxbury Z, Wang M-B. (2013)

Small RNAs and transgenerational epigenetic variation. American Journal of Plant Sciences 4 (3), 641-646.

Duxbury Z, Willows R, Smith PM, Chen M (2013)

The evolution of far-red light perception in Acaryochloris marina, a chlorophyll d-containing cyanobacterium. Photosynthesis Research for Food, Fuel and the Future: 15th International Conference on Photosynthesis pp 638-641.

Duxbury Z, Schliep M, Ritchie RJ, Larkum AWD, Chen M (2009)

Chromatic photoacclimation extends utilisable photosynthetically active radiation in the chlorophyll d-containing cyanobacterium, Acaryochloris marina. Photosynthesis Research 101 (1), 69-75.