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Dr Xiao Lin

Postdoctoral Scientist
Jonathan Jones Group

I am interested in plant-microbe interaction, especially the interaction between the Irish famine pathogen Phytophthora infestans and potato. I believe this knowledge will help to achieve more durable disease resistance in crop plants.

During my PhD, I focused on the MAMPs and apoplastic effectors from Phytophthora species and hunt for the corresponding surface immune receptors from potatoes. I used Effectoromics strategy to identify the Solanaceae plants which carry the potential surface immune receptors, then applied genetics, genomics, NGS and RLP/KSeq methods to map those surface immune receptors.

At TSL, I am aiming to identify the P. infestans effectors that recognized by NLR receptors from Solanum americanum. Once the effectors are identified, the distribution and evolution of these effectors in world-wide P. infestans races will be studied.

Publications

Lin X, Wang S, de Rond L, Bertolin N, Wouters RHM, Wouters D, Domazakis E, Bitew MK, Win J, Dong S, Visser RGF, Birch P, Kamoun S, Vleeshouwers VGAA (2020)

Divergent Evolution of PcF/SCR74 Effectors in Oomycetes Is Associated With Distinct Recognition Patterns in Solanaceous Plants. mBio. 2020 Jun 30;11(3):e00947-20. doi: 10.1128/mBio.00947-20.

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Witek K, Lin X, Karki HS, Jupe F, Witek AI, Steuernagel B, Stam R, Van Oosterhout C, Fairhead S, Cocker JM, Bhanvadia S, Barrett W, Song T, Vleeshouwers VGAA, Tomlinson L, Wulff BBH, Jones JDG (2020)

A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector. bioRxiv preprint May 15, 2020 doi: https://doi.org/10.1101/2020.05.15.095497

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Lin X, Song T, Fairhead S, Witek K, Jouet A, Jupe F, Witek AI, Vleeshouwers VGAA, Hein I, Jones JDG (2020)

Identification of Avramr1 from Phytophthora infestans using long read and cDNA pathogen-enrichment sequencing (PenSeq). bioRxiv preprint May 14, 2020 doi: https://doi.org/10.1101/2020.05.14.095158

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Lin X, Armstrong M, Baker K, Wouters D, Visser RGF, Wolters PJ, Hein I, Vleeshouwers VGAA (2020)

RLP/K enrichment sequencing; a novel method to identify receptor-like protein (RLP) and receptor-like kinase (RLK) genes. bioRxiv preprint Feb 26, 2020 doi: https://doi.org/10.1101/2020.02.26.966085

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Aguilera-Galvez C, Champouret N, Rietman H, Lin X, Wouters D, Chu Z, Jones JDG, Vossen JH, Visser RGF, Wolters PJ, Vleeshouwers VGAA (2018)

Two different R gene loci co-evolved with Avr2 of Phytophthora infestans and confer distinct resistance specificities in potato. Stud Mycol. 2018 Mar;89:105-115. doi: 10.1016/j.simyco.2018.01.002.

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Domazakis E, Lin X, Aguilera-Galvez C, Wouters D, Bijsterbosch G, Wolters PJ and Vleeshouwers VGAA (2017)

Effectoromics-based identification of cell surface receptors in potato. In: Shan L., He P. (eds) Plant Pattern Recognition Receptors. Methods in Molecular Biology, vol 1578. Humana Press, New York, NY. pp 337-353.

Derevnina L, Dagdas YF, De la Concepcion JC, Bialas A, Kellner R, Petre B, Domazakis E, Du J, Wu CH, Lin X, Aguilera-Galvez C, Cruz-Mireles N, Vleeshouwers VG, Kamoun S (2016)

Nine things to know about elicitins. New Phytol. 2016 Sep 1. doi: 10.1111/nph.14137.

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Lin X, Zhang Y, Kuang H, Chen J (2013)

Frequent loss of lineages and deficient duplications accounted for low copy number of disease resistance genes in Cucurbitaceae. BMC Genomics. 2013 May 17;14:335. doi: 10.1186/1471-2164-14-335.

Job History

2018 – present Postdoctoral Scientist, The Sainsbury Laboratory, Norwich, UK

2013 – 2018 PhD of Plant Breeding, Wageningen University & Research, Wageningen, Netherlands

2010 – 2013 MSc of Genomics, HuaZhong Agricultural University, Wuhan, China

2006 – 2010 BSc of Biological Science, HuaZhong Agricultural University, Wuhan, China