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Dr Sung Un Huh

Postdoctoral Scientist
Jonathan Jones Group

Hi, my name is Sung. My postdoctoral work (2013 – present) in the group of Prof. Jonathan Jones at The Sainsbury Laboratory is specifically focused on the investigation of large complexes of RPS4/RRS1, effector protein and other host proteins.

Research theme:  To understand the RPS4/RRS1 complex

Background: The Arabidopsis TIR-NB-LRR receptor RPS4 cooperates genetically with the WRKY domain containing TIR-NB-LRR immune receptor RRS1. Both RPS4 and RRS1 is required for AvrRps4/PopP2-triggered resistance towards Pseudomonas/Ralstonia infection. Interestingly, this phenotype relies on EDS1, as key TIR-NB-LRR regulator.

My research point:

1. Identification and verification of the RPS4/RRS1 complex in N. benthamiana and Arabidopsis

2. Biochemical properties and components of the RPS4/RRS1 complex

3. Identification of other proteins associated with the RPS4/RRS1 complex

4. Investigate unknown functions of EDS1 in this complex

These will enable us to define the function and composition of the RPS4/RRS1 complex.

Dr Sung Un Huh

sung.huh@tsl.ac.uk
+44 (0) 1603 450436

Publications

Duxbury Z, Ma Y, Furzer OJ, Huh SU, Cevik V, Jones JD, Sarris PF (2016)

Pathogen perception by NLRs in plants and animals: Parallel worlds. Bioessays. 2016 Jun 24. doi: 10.1002/bies.201600046.

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Sarris PF, Duxbury Z, Huh SU, Yan Ma, Segonzac C, Sklenar J, Derbyshire P, Cevik V, Rallapalli G, Saucet SB, Wirthmueller L, Menke FLH, Sohn KH, Jones JDG

A plant immune receptor detects pathogen effectors that target WRKY transcription factors. Cell Volume 161, Issue 5, p1089–1100

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Huh SU & Paek KH (2014)

APUM5, encoding a Pumilio RNA binding protein, negatively regulates abiotic stress responsive gene expression. BMC Plant Biol 14, 75

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Huh SU, Kim MJ & Paek KH (2013)

Arabidopsis Pumilio protein APUM5 suppresses Cucumber mosaic virus infection via direct binding of viral RNAs. Proc Natl Acad Sci U S A 110, 779-784

Huh SU, Kim MJ, Ham BK & Paek KH (2011)

A zinc finger protein Tsip1 controls Cucumber mosaic virus infection by interacting with the replication complex on vacuolar membranes of the tobacco plant. New Phytol 191, 746-762

Choi J, Huh SU, Kojima M, Sakakibara H, Paek KH & Hwang I (2010)

The cytokinin-activated transcription factor ARR2 promotes plant immunity via TGA3/NPR1-dependent salicylic acid signaling in Arabidopsis. Dev Cell 19, 284-295

Kim MJ, Huh SU, Ham BK & Paek KH (2008)

A novel methyltransferase methylates Cucumber mosaic virus 1a protein and promotes systemic spread. J Virol 82, 4823-4833

Job History

2013 – present Postdoctoral Scientist, The Sainsbury Laboratory, Norwich, UK.

2011 – 2013 Postdoctoral Research Associate, Korea University, Seoul, Korea.

2005 – 2011 PhD Student, Korea University, Seoul, Korea.