Dr Pingtao Ding

Postdoctoral Scientist
Jonathan Jones Group

I am interested in direct/indirect transcriptional regulation as well as the detailed molecular mechanism of defence gene activation in effector-triggered immunity.

My research of interest is based on the knowledge of divergently transcribed resistance (R) gene pairs, RPS4 (resistance to Pseudomonas syringae 4) and RRS1 (resistance to Ralstonia solanacearum 1) from Arabidopsis thaliana. They have been reported to function together in defence against bacterial pathogens, Pseudomonas syringae (AvrRps4) and Ralstonia solanacearum (PopP2), as well as the fungus Colletotrichum higginsianum. slh1 (sensitive to low humidity 1) has been reported to encode a mutated RRS1 protein with attenuated DNA binding activity in vitro. slh1 plants display dwarf, and autoimmune phenotypes. Accordingly, I am intrigued by the question whether RRS1/RPS4 function by targeting multiple defence-related genes directly, and activates the downstream events through the transcriptional regulation during effector triggered immunity. Chromatin immunoprecipitation sequencing (ChIP-seq) will be developed to unravel this question.

Dr Pingtao Ding
+44 (0) 1603 450436
Research Gate: Pingtao_Ding


Ngou BPM, Ahn HK, Ding P, Jones JDG (2021)

Mutual potentiation of plant immunity by cell-surface and intracellular receptors. Nature (2021).

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Duxbury Z, Wu CH, Ding P (2021)

A Comparative Overview of the Intracellular Guardians of Plants and Animals: NLRs in Innate Immunity and Beyond. Annu Rev Plant Biol. 2021 Mar 9. doi: 10.1146/annurev-arplant-080620-104948.

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Yuan M, Ngou BPM, Ding P, Xin XF (2021)

PTI-ETI crosstalk: an integrative view of plant immunity. Curr Opin Plant Biol. 2021 Mar 5;62:102030. doi: 10.1016/j.pbi.2021.102030.

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Bjornson M, Kajala K, Zipfel C, Ding P (2020)

Low-cost and High-throughput RNA-seq Library Preparation for Illumina Sequencing from Plant Tissue. Bio Protoc. 2020 Oct 20;10(20):e3799. doi: 10.21769/BioProtoc.3799. eCollection 2020 Oct 20.

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Duxbury Z, Wang S, MacKenzie CI, Tenthorey JL, Zhang X, Huh SU, Hu L, Hill L, Ngou PM, Ding P, Chen J, Ma Y, Guo H, Castel B, Moschou PN, Bernoux M, Dodds PN, Vance RE, Jones JDG (2020)

Induced proximity of a TIR signaling domain on a plant-mammalian NLR chimera activates defense in plants. Proc Natl Acad Sci U S A. 2020 Jul 24:202001185. doi: 10.1073/pnas.2001185117.

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Ding P, Sakai T, Shrestha RK, Perez NM, Guo W, Ngou BPM, He S, Liu C, Feng X, Zhang R, Vandepoele K, MacLean D, Jones JDG (2020)

Chromatin accessibility landscapes activated by cell surface and intracellular immune receptors. bioRxiv preprint June 18, 2020 doi:

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Ngou BPM, Ahn HK, Ding P, Jones JDG (2020)

Mutual Potentiation of Plant Immunity by Cell-surface and Intracellular Receptors. bioRxiv preprint Apr 10, 2020 doi:

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Guo H, Ahn HK, Sklenar J, Huang J, Ma Y, Ding P, Menke FLH, Jones JDG (2020)

Phosphorylation-Regulated Activation of the Arabidopsis RRS1-R/RPS4 Immune Receptor Complex Reveals Two Distinct Effector Recognition Mechanisms. Cell Host Microbe. 2020 Mar 29. pii: S1931-3128(20)30172-4. doi: 10.1016/j.chom.2020.03.008.

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Ngou BPM, Ahn HK, Ding P, Redkar A, Brown H, Ma Y, Youles M, Tomlinson L, Jones JDG (2020)

Estradiol-inducible AvrRps4 expression reveals distinct properties of TIR-NLR-mediated effector-triggered immunity. J Exp Bot. 2020 Feb 12. pii: erz571. doi: 10.1093/jxb/erz571.

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Ding P, Ding Y (2020)

Stories of Salicylic Acid: A Plant Defense Hormone. Trends in Plant Science

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Ding P, Ngou BPM, Furzer OJ, Sakai T, Shrestha RK, MacLean D, Jones JDG (2020)

High-resolution Expression Profiling of Selected Gene Sets during Plant Immune Activation. Plant Biotechnol J. 2020 Jan 8. doi: 10.1111/pbi.13327.

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Ding P, Ngou BPM, Oliver J. Furzer OJ, Sakai T, Shrestha RK, MacLean D, Jones JDG (2019)

High-resolution Expression Profiling of Selected Gene Sets during Plant Immune Activation. bioRxiv preprint Sep 23, 2019 doi:

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Ngou BPM, Ahn HK, Ding P, Redkar A, Brown H, Ma Y, Youles M, Tomlinson L, Jones JDG (2019)

Estradiol-inducible AvrRps4 expression reveals distinct properties of TIR-NLR-mediated effector-triggered immunity. bioRxiv preprint Jul 14, 2019 doi:

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Castel B, Ngou PM, Cevik V, Redkar A, Kim DS, Yang Y, Ding P, Jones JDG (2018)

Diverse NLR immune receptors activate defence via the RPW8-NLR NRG1. New Phytol. 2018 Dec 24. doi: 10.1111/nph.15659.

Ma Y, Guo H, Hu L, Martinez PP, Moschou PN, Cevik V, Ding P, Duxbury Z, Sarris PF, Jones JDG (2018)

Distinct modes of derepression of an Arabidopsis immune receptor complex by two different bacterial effectors. Proc Natl Acad Sci U S A. 2018 Sep 25. pii: 201811858. doi: 10.1073/pnas.1811858115.

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Ding P, Redkar A (2018)

Pathogens Suppress Host Transcription Factors for Rampant Proliferation. Trends In Plant Science. doi:

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Shrestha RK, Ding P, Jones JDG, MacLean D (2018)

A workflow for simplified analysis of ATAC-cap-seq data in R. GigaScience, 2017, 1–7. DOI: 10.1093/gigascience/giy080

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Ding P, Guo H, Jones JDG (2018)

Deadlier than the malate. Cell Res. 2018 May 29. doi: 10.1038/s41422-018-0042-6.

Huh SU, Cevik V, Ding P, Duxbury Z, Ma Y, Tomlinson L, Sarris PF, Jones JDG (2017)

Protein-protein interactions in the RPS4/RRS1 immune receptor complex. PLoS Pathog. 2017 May 5;13(5):e1006376. doi: 10.1371/journal.ppat.1006376.

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Ding P, Jones JDG (2017)

Mis-placed Congeniality: When Pathogens Ask Their Plant Hosts for Another Drink. Developmental Cell 40, p116–117,DOI:

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Ding P, Rekhter D, Ding Y, Feussner K, Busta L, Haroth S, Xu S, Li X, Jetter R, Feussner I, Zhang Y (2016)

Characterization of a pipecolic acid biosynthesis pathway required for systemic acquired resistance. Plant Cell. 2016 Oct 6. pii: tpc.00486.2016.

Liang X, Ding P, Lian K, Wang J, Ma M, Li L, Li L, Li M, Zhang X, Chen S, Zhang Y, Zhou JM (2016)

Arabidopsis heterotrimeric G proteins regulate immunity by directly coupling to the FLS2 receptor. Elife. (2016) Apr 4;5. pii: e13568. doi: 10.7554/eLife.13568.

Nitta Y, Ding P, Zhang Y (2015)

Heterotrimeric G proteins in plant defense against pathogens and ABA signalling. Environ Exper Bot. (2015) Jun 114:153–158. doi:10.1016/j.envexpbot.2014.06.011

Nitta Y, Ding P, Zhang Y (2014)

Identification of additional MAP kinases activated upon PAMP treatment. Plant Signal Behav. (2014) 9(11):e976155. doi: 10.4161/15592324.2014.976155.

Zhang Z, Liu Y, Ding P, Li Y, Kong Q, Zhang Y (2014)

Splicing of receptor-like kinase-encoding SNC4 and CERK1 is regulated by two conserved splicing factors that are required for plant immunity. Mol Plant. (2014) Dec;7(12):1766-75. doi: 10.1093/mp/ssu103. Epub 2014 Sep 29.

Liu J, Ding P, Sun T, Nitta Y, Dong O, Huang X, Yang W, Li X, Botella J, Zhang Y. (2013)

Heterotrimeric G proteins serve as a converging point in plant defense signaling activated by multiple receptor-like kinases. Plant Physiol.

Yang Y, Zhang Y, Ding P, Johnson K, Li X, Zhang Y. (2012)

The ankyrin-repeat transmembrane protein BDA1 functions downstream of the receptor-like protein SNC2 to regulate plant immunity. Plant Physiol. 159(4):1857-65

Germain H, Qu N, Cheng YT, Lee E, Huang Y, Dong OX, Gannon P, Huang S, Ding P, Li Y, Sack F, Zhang Y, Li X. (2010)

MOS11: a new component in the mRNA export pathway. PLoS Genet. 6(12):e1001250

Zhang Y, Xu S, Ding P*, Wang D, Cheng YT, He J, Gao M, Xu F, Li Y, Zhu Z, Li X, Zhang Y. (2010)

Control of salicylic acid synthesis and systemic acquired resistance by two members of a plant-specific family of transcription factors. Proc Natl Acad Sci U S A. 107(42):18220–18225

Zhang Y, Yang Y, Fang B, Gannon P, Ding P, Li X, Zhang Y. (2010)

Arabidopsis snc2-1D activates receptor-like protein-mediated immunity transduced through WRKY70. Plant Cell. 22(9):3153-63

Job History

2016 – present Postdoctoral Fellow (Marie-Curie), The Sainsbury Laboratory, Norwich, UK.

2013 – 2016 Postdoctoral Scientist, The Sainsbury Laboratory, Norwich, UK.

2011 -2013 Visiting PhD Scholar, Michael Smith Laboratories (MSL), University of British Columbia, Vancouver, Canada.

2008 – 2013 PhD in Biochemistry and Molecular Biology, National Institute of Biological Sciences (NIBS) & Beijing Normal University, Beijing, China.

2004 – 2008 BSc Student, Wuhan University (WHU), Wuhan, China.