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Dr Pingtao Ding

Postdoctoral Scientist
Jonathan Jones Group

I am interested in direct/indirect transcriptional regulation as well as the detailed molecular mechanism of defence gene activation in effector-triggered immunity.

My research of interest is based on the knowledge of divergently transcribed resistance (R) gene pairs, RPS4 (resistance to Pseudomonas syringae 4) and RRS1 (resistance to Ralstonia solanacearum 1) from Arabidopsis thaliana. They have been reported to function together in defence against bacterial pathogens, Pseudomonas syringae (AvrRps4) and Ralstonia solanacearum (PopP2), as well as the fungus Colletotrichum higginsianum. slh1 (sensitive to low humidity 1) has been reported to encode a mutated RRS1 protein with attenuated DNA binding activity in vitro. slh1 plants display dwarf, and autoimmune phenotypes. Accordingly, I am intrigued by the question whether RRS1/RPS4 function by targeting multiple defence-related genes directly, and activates the downstream events through the transcriptional regulation during effector triggered immunity. Chromatin immunoprecipitation sequencing (ChIP-seq) will be developed to unravel this question.

Dr Pingtao Ding

pingtao.ding@tsl.ac.uk
+44 (0) 1603 450436
Research Gate: Pingtao_Ding

Publications

Huh SU, Cevik V, Ding P, Duxbury Z, Ma Y, Tomlinson L, Sarris PF, Jones JDG (2017)

Protein-protein interactions in the RPS4/RRS1 immune receptor complex. PLoS Pathog. 2017 May 5;13(5):e1006376. doi: 10.1371/journal.ppat.1006376.

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Ding P, Jones JDG (2017)

Mis-placed Congeniality: When Pathogens Ask Their Plant Hosts for Another Drink. Developmental Cell 40, p116–117,DOI: http://dx.doi.org/10.1016/j.devcel.2017.01.003

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Ding P, Rekhter D, Ding Y, Feussner K, Busta L, Haroth S, Xu S, Li X, Jetter R, Feussner I, Zhang Y (2016)

Characterization of a pipecolic acid biosynthesis pathway required for systemic acquired resistance. Plant Cell. 2016 Oct 6. pii: tpc.00486.2016.

Liang X, Ding P, Lian K, Wang J, Ma M, Li L, Li L, Li M, Zhang X, Chen S, Zhang Y, Zhou JM (2016)

Arabidopsis heterotrimeric G proteins regulate immunity by directly coupling to the FLS2 receptor. Elife. (2016) Apr 4;5. pii: e13568. doi: 10.7554/eLife.13568.

Nitta Y, Ding P, Zhang Y (2015)

Heterotrimeric G proteins in plant defense against pathogens and ABA signalling. Environ Exper Bot. (2015) Jun 114:153–158. doi:10.1016/j.envexpbot.2014.06.011

Nitta Y, Ding P, Zhang Y (2014)

Identification of additional MAP kinases activated upon PAMP treatment. Plant Signal Behav. (2014) 9(11):e976155. doi: 10.4161/15592324.2014.976155.

Zhang Z, Liu Y, Ding P, Li Y, Kong Q, Zhang Y (2014)

Splicing of receptor-like kinase-encoding SNC4 and CERK1 is regulated by two conserved splicing factors that are required for plant immunity. Mol Plant. (2014) Dec;7(12):1766-75. doi: 10.1093/mp/ssu103. Epub 2014 Sep 29.

Liu J, Ding P, Sun T, Nitta Y, Dong O, Huang X, Yang W, Li X, Botella J, Zhang Y. (2013)

Heterotrimeric G proteins serve as a converging point in plant defense signaling activated by multiple receptor-like kinases. Plant Physiol.

Yang Y, Zhang Y, Ding P, Johnson K, Li X, Zhang Y. (2012)

The ankyrin-repeat transmembrane protein BDA1 functions downstream of the receptor-like protein SNC2 to regulate plant immunity. Plant Physiol. 159(4):1857-65

Germain H, Qu N, Cheng YT, Lee E, Huang Y, Dong OX, Gannon P, Huang S, Ding P, Li Y, Sack F, Zhang Y, Li X. (2010)

MOS11: a new component in the mRNA export pathway. PLoS Genet. 6(12):e1001250

Zhang Y, Xu S, Ding P*, Wang D, Cheng YT, He J, Gao M, Xu F, Li Y, Zhu Z, Li X, Zhang Y. (2010)

Control of salicylic acid synthesis and systemic acquired resistance by two members of a plant-specific family of transcription factors. Proc Natl Acad Sci U S A. 107(42):18220–18225

Zhang Y, Yang Y, Fang B, Gannon P, Ding P, Li X, Zhang Y. (2010)

Arabidopsis snc2-1D activates receptor-like protein-mediated immunity transduced through WRKY70. Plant Cell. 22(9):3153-63

Job History

2016 – present Postdoctoral Fellow (Marie-Curie), The Sainsbury Laboratory, Norwich, UK.

2013 – 2016 Postdoctoral Scientist, The Sainsbury Laboratory, Norwich, UK.

2011 -2013 Visiting PhD Scholar, Michael Smith Laboratories (MSL), University of British Columbia, Vancouver, Canada.

2008 – 2013 PhD in Biochemistry and Molecular Biology, National Institute of Biological Sciences (NIBS) & Beijing Normal University, Beijing, China.

2004 – 2008 BSc Student, Wuhan University (WHU), Wuhan, China.