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Dr Paul Derbyshire

Proteomics Support Specialist
Proteomics

As part of the Proteomics Group I specialise in targeted proteomics and use Selected Reaction Monitoring (SRM) to quantify post-translational modifications (e.g. phosphorylation, acetylation) of plant proteins following elicitation by pathogens. I am also part of the discovery platform used for the identification of the protein components of samples, including their post-translational modifications.

Other research interests include:

Plant cell walls and growth. Microtubules and secondary wall patterning. Root development. Leaf patterning. Starch metabolism.

Dr Paul Derbyshire

paul.derbyshire@jic.ac.uk
+44 (0) 1603 450225

Publications

Bender KW, Blackburn RK, Monaghan J, Derbyshire P, Menke FL, Zipfel C, Goshe MB, Zielinski RE, Huber SC (2017)

Autophosphorylation-based calcium (Ca2+) sensitivity priming and Ca2+/Calmodulin inhibition of Arabidopsis thaliana Ca2+-dependent protein kinase 28 (CPK28). J Biol Chem. 2017 Jan 30. pii: jbc.M116.763243. doi: 10.1074/jbc.M116.763243.

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Couto D, Niebergall R, Liang X, Bücherl CA, Sklenar J, Macho AP, Ntoukakis V, Derbyshire P, Altenbach D, Maclean D, Robatzek S, Uhrig J, Menke F, Zhou JM, Zipfel C (2016)

The Arabidopsis Protein Phosphatase PP2C38 Negatively Regulates the Central Immune Kinase BIK1. PLoS Pathog. 12(8):e1005811. doi: 10.1371/journal.ppat.1005811.

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Mithoe SC, Ludwig C, Pel MJC, Cucinotta M, Casartelli A, Mbengue M, Sklenar J, Derbyshire P, Robatzek S, Pieterse CMJ, Aebersold R, Menke FLH (2015)

Attenuation of pattern recognition receptor signaling is mediated by a MAP kinase kinase kinase. EMBO reports (2016). DOI 10.15252/embr.201540806

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Sarris PF, Duxbury Z, Huh SU, Yan Ma, Segonzac C, Sklenar J, Derbyshire P, Cevik V, Rallapalli G, Saucet SB, Wirthmueller L, Menke FLH, Sohn KH, Jones JDG

A plant immune receptor detects pathogen effectors that target WRKY transcription factors. Cell Volume 161, Issue 5, p1089–1100

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Macho AP, Schwessinger B, Ntoukakis V, Brutus A, Segonzac C, Roy S, Kadota Y, Oh MH, Sklenar J, Derbyshire P, Lozano-Duran R, Gro Malinovsky F, Monaghan J, Menke FL, Huber SC, He SY and Zipfel C (2014)

A bacterial tyrosine phosphatase inhibits plant pattern recognition receptor activation. Science, 343 (6178): 1509-1512.

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Kadota Y, Sklenar J, Derbyshire P, Stransfeld L, Asai S, Ntoukakis V, Jones JDG, Shirasu K, Menke FL, Jones A and Zipfel C (2014)

Direct regulation of the NADPH oxidase RBOHD by the PRR-associated kinase BIK1 during plant immunity. Molecular Cell, 54 (1): 43-55.

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Derbyshire P., Byrne M. E. (2013)

MORE SPIKELETS1 Is Required for Spikelet Fate in the Inflorescence of Brachypodium. Plant Physiology 161, 1291-302

Moschopoulos A., Derbyshire P., Byrne M. E. (2012)

The Arabidopsis organelle-localized glycyl-tRNA synthetase encoded by EMBRYO DEFECTIVE DEVELOPMENT1 is required for organ patterning Journal of Experimental Botany 63 5233-5243

Barratt D. H., Derbyshire P., Findlay K., Pike M., Wellner N., Lunn J., Feil R., Simpson C., Maule A. J., Smith A. M. (2009)

Normal growth of Arabidopsis requires cytosolic invertase but not sucrose synthase. Proceedings of the National Academy of Sciences of the United States of America 106, 13124-13129

Drea S., Derbyshire P., Koumproglou R., Dolan L., Doonan J. H., Shaw P.(2009)

In situ analysis of gene expression in plants Methods in Molecular Biology 513 229-42

Lee Y., Derbyshire P., Knox J. P., Hvoslef-Eide A. K. (2008)

Sequential cell wall transformations in response to the induction of a pedicel abscission event in Euphorbia pulcherrima (poinsettia). Plant Journal 6, 993-1003

Derbyshire P., Drea S., Shaw P. J., Doonan J. H., Dolan L. (2008)

Proximal-distal patterns of transcription factor gene expression during Arabidopsis root development. Journal of Experimental Botany 59, 235-245

Li Y., Smith C. H., Corke F., Zheng L., Merali Z., Ryden P., Derbyshire P., Waldron K., Bevan M. W. (2007)

Signaling from an altered cell wall to the nucleus mediates sugar-responsive growth and development in Arabidopsis thaliana. Plant Cell 19, 2500-15

Derbyshire P., McCann M. C., Roberts K. (2007)

Restricted cell elongation in Arabidopsis hypocotyls is associated with a reduced average pectin esterification level. BMC Plant Biology 7, article 31

Derbyshire P., Findlay K., McCann M. C., Roberts K. (2007)

Cell elongation in Arabidopsis hypocotyls involves dynamic changes in cell wall thickness. Journal of Experimental Botany 58 2079-2089

Carol R. J., Takeda S., Linstead P., Durrant M. C., Kakesova H., Derbyshire P., Drea S., Zarsky V., Dolan L. (2005)

A RhoGDP dissociation inhibitor spatially regulates growth in root hair cells. Nature 438, 1013-1016

Schindelman G., Morikami A., Jung J., Baskin T. I., Carpita N. C., Derbyshire P., McCann M. C., Benfey P. N. (2001)

COBRA encodes a putative GPI-anchored protein, which is polarly localized and necessary for oriented cell expansion in Arabidopsis. Genes & Development 15, 1115-1127