My interest in Plant Pathology started during my Agricultural Engineering studies at Universidad Pública de Navarra in Spain. I then decided to specialize more and I moved to Wageningen University (The Netherlands) where I completed my master’s degree in Plant Pathology and Entomology. During my master’s degree I investigated the mode of action of NEP proteins in the grey mould fungus Botrytis cinerea in the laboratory of Dr. Jan van Kan. As part of my intership I joined the laboratory of Prof. Sophien Kamoun at TSL where I focused in the identification of plant targets and function characterization of RxLR cytoplasmic effectors of the oomycete Phytophtora infestans. In 2010 I joined Professor Nick Talbot’s research group to be part of a Marie Curie Initial Training Network program called ARIADNE and carry out my PhD. The main objective of ARIADNE was to identify and characterize conserved and specific fungal virulence genes as common antifungal targets, and specifically, we investigated the role of MAP kinase signalling pathways in a diverse group of fungi. I used a Comparative Transcriptomic approach using RNA-seq to define a hierarchical transcriptional model regulating appressorium morphogenesis and infection in Magnaporthe oryzae.
My main interest is being to understand cellular developmental processes and morphogenesis associated with appressorium formation in the rice blast fungus Magnaporthe oryzae. My main focus is to understand how cell cycle progression controls appressorium development and what are the cell cycle check points required for appressorium morphogenesis and invasive growth. I am also interested and involved in understanding the mechanism of the cell-to-cell movement during plant invasion, in cell surface perception and in how the homebox transcription factor Hox7 controls morphogenesis in Magnaporthe oryzae.
Miriam.Oses-Ruiz@tsl.ac.uk
+44 (0) 1603 450418
Research Gate: Miriam_Oses-Ruiz
A single fungal MAP kinase controls plant cell-to-cell invasion by the rice blast fungus. Science. 2018 Mar 23;359(6382):1399-1403. doi: 10.1126/science.aaq0892.
Cell cycle-dependent regulation of plant infection by the rice blast fungus Magnaporthe oryzae. Commun Integr Biol. 2017 Oct 5;10(5-6):e1372067. doi: 10.1080/19420889.2017.1372067.
The cyclin dependent kinase subunit Cks1 is required for infection-associated development of the rice blast fungus Magnaporthe oryzae. Environ Microbiol. 2017 Oct;19(10):3959-3981. doi: 10.1111/1462-2920.13796.
Two independent S-phase checkpoints regulate appressorium-mediated plant infection by the rice blast fungus Magnaporthe oryzae. Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E237-E244. doi: 10.1073/pnas.1611307114.
Investigating the biology of plant infection by the rice blast fungus Magnaporthe oryzae. Fungal Genet Biol. 2016 May;90:61-68. doi: 10.1016/j.fgb.2015.12.009.
Fungal model systems and the elucidation of pathogenicity determinants. Fungal Genet Biol. 2014 Sep;70:42-67. doi: 10.1016/j.fgb.2014.06.011.
Functional analysis and mode of action of phytotoxic Nep1-like proteins of Botrytis cinerea. Physiological and Molecular Plant Pathology Volume 74, Issues 5–6, September 2010, Pages 376-386
2018 – present Research Fellow, The Sainsbury Laboratory, Norwich, UK
2014 – 2018 Research Fellow, University of Exeter, UK
2010 – 2014 PhD, University of Exeter, UK
2009 – 2010 Researcher, Universidad Publica de Navarra, Spain
2008 Internship, The Sainsbury Laboratory, Norwich, UK
2006 – 2008 MSc Plant Pathology and Entomology, Wageningen University, The Netherlands
2002 – 2009 Agricultural Engineering, Universidad Publica de Navarra, Spain