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Dr Matthew Moscou

My group’s research focuses on understanding the genetic architecture underlying nonhost resistance. We use natural and induced variation within nonhost species to identify the genetic loci specifying resistance.

Our efforts are concentrated on the cereal rusts and their interaction with several grass species, including barley (Hordeum vulgare) and purple false brome (Brachypodium distachyon).

Our long-term goal is to identify and clone the molecular components underlying nonhost resistance and engineer this resistance in wheat.

matthew.moscou@tsl.ac.uk
+44 (0) 1603 450296

Publications

Mascher M, Wicker T, Jenkins J, Plott C, Lux T, Koh CS, Ens J, Gundlach H, Boston LB, Tulpová Z, Holden S, Hernández-Pinzón I, Scholz U, Mayer KFX, Spannagl M, Pozniak CJ, Sharpe AG, Šimková H, Moscou MJ, Grimwood J, Schmutz J, Stein N (2021)

Long-read sequence assembly: a technical evaluation in barley. Plant Cell. 2021 Mar 12:koab077. doi: 10.1093/plcell/koab077.

Białas A, Langner T, Harant A, Contreras MP, Stevenson CEM, Lawson DM, Sklenar J, Kellner R, Moscou MJ, Terauchi R, Banfield MJ, Kamoun S (2020)

Two NLR immune receptors acquired high-affinity binding to a fungal effector through convergent evolution of their integrated domain. bioRxiv preprint Jan 27, 2021 doi: https://doi.org/10.1101/2021.01.26.428286

Panstruga R, Moscou MJ (2020)

What is the molecular basis of nonhost resistance? Mol Plant Microbe Interact. 2020 Aug 18. doi: 10.1094/MPMI-06-20-0161-CR.

Read AC, Hutin M, Moscou MJ, Rinaldi FC, Bogdanove AJ (2020)

Cloning of the rice Xo1 resistance gene and interaction of the Xo1 protein with the defense-suppressing Xanthomonas effector Tal2h. Mol Plant Microbe Interact. 2020 Aug 4. doi: 10.1094/MPMI-05-20-0131-SC.

Read AC, Hutin M, Moscou MJ, Rinaldi FC, Bogdanove AJ (2020)

Cloning of the rice Xo1 resistance gene and interaction of the Xo1 protein with the defense-suppressing Xanthomonas effector Tal2h. bioRxiv preprint May 29, 2020 doi: https://doi.org/10.1101/2020.05.26.116731

Wei B, Moscou MJ, Sato K, Gourlie R, Strelkov S, Aboukhaddour R (2020)

Identification of a Locus Conferring Dominant Susceptibility to Pyrenophora tritici-repentis in Barley. Front Plant Sci. 2020 Feb 28;11:158. doi: 10.3389/fpls.2020.00158. eCollection 2020.

Hiebert CW, Moscou MJ, Hewitt T, Steuernagel B, Hernández-Pinzón I, Green P, Pujol C, Zhang P, Rouse MN, Jin Y, McIntosh RA, Upadhyayac N, Zhang J, Bhavani S, Jan Vrána J, Karafiátová M, Huang L, Fetch T, Doležel J, Wulff BH, Lagudah E, Spielmeyer W (2020)

Stem rust resistance in wheat is suppressed by a subunit of the mediator complex. Nature Communications volume 11, Article number: 1123 (2020)

Read AC, Moscou MJ, Zimin AV, Pertea G, Meyer RS, Purugganan MD, Leach JE, Triplett LR, Salzberg SL, Bogdanove AJ (2020)

Genome assembly and characterization of a complex zfBED-NLR gene-containing disease resistance locus in Carolina Gold Select rice with Nanopore sequencing. PLoS Genet. 2020 Jan 27;16(1):e1008571. doi: 10.1371/journal.pgen.1008571.

Read AC, Moscou MJ, Zimin AV, Pertea G, Meyer RS, Purugganan MD, Leach JE, Triplett LR, Salzberg SL, Bogdanove AJ (2019)

Genome assembly and characterization of a complex zfBED-NLR gene-containing disease resistance locus in Carolina Gold Select rice with Nanopore sequencing. bioRxiv preprint Jun 20, 2019 doi: https://doi.org/10.1101/675678

Ghosh S, Watson A, Gonzalez-Navarro OE, Ramirez-Gonzalez RH, Yanes L, Mendoza-Suárez M, Simmonds J, Wells R, Rayner T, Green P, Hafeez A, Hayta S, Melton RE, Steed A, Sarkar A, Carter J, Perkins L, Lord J, Tester M, Osbourn A, Moscou MJ, Nicholson P, Harwood W, Martin C, Domoney C, Uauy C, Hazard B, Wulff BBH, Hickey LT (2018)

Speed breeding in growth chambers and glasshouses for crop breeding and model plant research. Nat Protoc. 2018 Nov 16. doi: 10.1038/s41596-018-0072-z.

Gilbert B, Bettgenhaeuser J, Upadhyaya N, Soliveres M, Singh D, Park RF, Moscou MJ, Ayliffe M (2018)

Components of Brachypodium distachyon resistance to nonadapted wheat stripe rust pathogens are simply inherited. PLoS Genet. 2018 Sep 28;14(9):e1007636. doi: 10.1371/journal.pgen.1007636. eCollection 2018 Sep.

Bettgenhaeuser J, Gardiner M, Spanner R, Green P, Hernández-Pinzón I, Hubbard A, Ayliffe M, Moscou MJ (2018)

The genetic architecture of colonization resistance in Brachypodium distachyon to non-adapted stripe rust (Puccinia striiformis) isolates. PLoS Genet. 2018 Sep 28;14(9):e1007637. doi: 10.1371/journal.pgen.1007637. eCollection 2018 Sep.

Omidvar V, Dugyala S, Li F, Rottschaefer S, Miller M, Ayliffe M, Moscou MJ, Kianian SF, Figueroa M (2018)

Detection of race-specific resistance against Puccinia coronata f. sp. avenae in Brachypodium species. Phytopathology. 2018 Jun 20. doi: 10.1094/PHYTO-03-18-0084-R.

Bailey PC, Schudoma C, Jackson W, Baggs E, Dagdas G, Haerty W, Moscou M, Krasileva KV (2018)

Dominant integration locus drives continuous diversification of plant immune receptors with exogenous domain fusions. Genome Biol. 2018 Feb 19;19(1):23. doi: 10.1186/s13059-018-1392-6.

Brabham HJ, Hernández-Pinzón I, Holden S, Lorang J, Moscou MJ (2017)

An ancient integration in a plant NLR is maintained as a trans-species polymorphism. bioRxiv preprint Dec 25, 2017 doi: https://doi.org/10.1101/239541

Moscou MJ, van Esse HP (2017)

The quest for durable resistance. Science: Vol. 358, Issue 6370, pp. 1541-1542 DOI: 10.1126/science.aar4797

Herb D, Filichkin T, Fisk S, Helgerson L, Hayes P, Benson A, Vega V, Carey D, Thiel R, Cistue L, Jennings R, Monsour R, Tynan S, Vinkemeier K, Li Y, Nguygen A, Onio A, Meints B, Moscou M, Romagosa I, Thomas W (2017)

Malt Modification and Its Effects on the Contributions of Barley Genotype to Beer Flavor. J. Am. Soc. Brew. Chem. 75(4):354-362, 2017.

Herb D, Filichkin F, Fisk S, Helgerson L, Hayes P, Meints B, Jennings R, Monsour R, Tynan S, Vinkemeier K, Romagosa I, Moscou M, Carey D, Thiel R, Cistue L, Martens C, Thomas W (2017)

Effects of Barley (Hordeum vulgare L.) Variety and Growing Environment on Beer Flavor. J. Am. Soc. Brew. Chem. 75(4):345-353, 2017.

Bailey PC, Schudoma C, Jackson W, Baggs E, Dagdas G, Haerty W, Moscou M, Krasileva KV (2017)

Dominant integration locus drives continuous diversification of plant immune receptors with exogenous domain fusions. bioRxiv preprint Aug 19, 2017 doi: https://doi.org/10.1101/100834

Yu G, Champouret N, Steuernagel B, Olivera PD, Simmons J, Williams C, Johnson R, Moscou MJ, Hernández-Pinzón I, Green P, Sela H, Millet E, Jones JD, Ward ER, Steffenson BJ, Wulff BB (2017)

Discovery and characterization of two new stem rust resistance genes in Aegilops sharonensis. Theor Appl Genet. 2017 Mar 8. doi: 10.1007/s00122-017-2882-8.

Hisano H, Meints B, Moscou MJ, Cistue L, Echávarri B, Sato K, Hayes PM

Selection of transformation-efficient barley genotypes based on TFA (transformation amenability) haplotype and higher resolution mapping of the TFA loci. Plant Cell Rep. 2017 Feb 15. doi: 10.1007/s00299-017-2107-2.

Clare S, Kitcher W, Gardiner M, Green P, Hubbard A, Moscou MJ (2016)

Defining the genetic architecture of stripe rust resistance in the barley accession HOR 1428. bioRxiv preprint December 13, 2016 doi: http://dx.doi.org/10.1101/09377

Bettgenhaeuser J, Corke FM, Opanowicz M, Green P, Hernández-Pinzón I, Doonan JH, Moscou MJ (2016)

Natural variation in Brachypodium links vernalization and flowering time loci as major flowering determinants. Plant Physiol. 2016 Sep 20. pii: pp.00813.2016.

Le Fevre R, O'Boyle B, Moscou MJ, Schornack S (2016)

Colonization of barley by the broad-host hemibiotrophic pathogen Phytophthora palmivora uncovers a leaf development dependent involvement of MLO. Mol Plant Microbe Interact. 2016 Feb 29.

Dawson AM, Ferguson JN, Gardiner M, Green P, Hubbard A, Moscou MJ (2015)

Isolation and fine mapping of Rps6: an intermediate host resistance gene in barley to wheat stripe rust. Theor Appl Genet. 2016 doi:10.1007/s00122-015-2659-x

Dawson AM, Bettgenhaeuser J, Gardiner M, Green P, Hernández-Pinzón I, Hubbard A, Moscou MJ (2015)

The development of quick, robust, quantitative phenotypic assays for describing the host–nonhost landscape to stripe rust. Front. Plant Sci., 27 October 2015

Muñoz-Amatriaín M, Lonardi S, Luo M, Madishetty K, Svensson JT, Moscou MJ, Wanamaker S, Jiang T, Kleinhofs A, Muehlbauer GJ, Wise RP, Stein N, Ma Y, Rodriguez E, Kudrna D, Bhat PR, Chao S, Condamine P, Heinen S, Resnik J, Wing R, Witt HN, Alpert M, Beccuti M, Bozdag S, Cordero F, Mirebrahim H, Ounit R, Wu Y, You F, Zheng J, Šimková H, Doležel J, Grimwood J, Schmutz J, Duma D, Altschmied L, Blake T, Bregitzer P, Cooper L, Dilbirligi M, Falk A, Feiz L, Graner A, Gustafson P, Hayes PM, Lemaux P, Mammadov J Close TJ (2015)

Sequencing of 15,622 gene-bearing BACs clarifies the gene-dense regions of the barley genome. Plant J. 2015 Aug 7. doi: 10.1111/tpj.12959.

Knight E, Binnie A, Draeger T, Moscou M, Rey MD, Sucher J, Mehra S, King I, Moore G (2015)

Mapping the ‘breaker’ element of the gametocidal locus proximal to a block of sub-telomeric heterochromatin on the long arm of chromosome 4Ssh of Aegilops sharonensis. Theoretical and Applied Genetics DOI 10.1007/s00122-015-2489-x

Wulff BH and Moscou MJ (2014)

Strategies for transferring resistance into wheat: from wide crosses to GM cassettes. Front. Plant Sci., 04 December 2014. doi: 10.3389/fpls.2014.00692

Bettgenhaeuser J, Gilbert B, Ayliffe M, Moscou MJ (2014)

Nonhost resistance to rust pathogens – a continuation of continua. Front. Plant Sci. doi: 10.3389/fpls.2014.00664

Ayliffe, M. Singh, D., Park, R., Moscou, M., Pryor, T. (2013)

The infection of Brachypodium distachyon with selected grass rust pathogens. Molecular Plant-Microbe Interactions. 26(8): 946-957.

Bouyioukos c., Moscou M. J., Champouret N., Hernández-Pinzón I., Ward E. R. and Wulff B.B. H. (2013).

Characterisation and Analysis of the Aegilops sharonensis Transcriptome, a Wild Relative of Wheat in the Sitopsis Section

Muñoz-Amatriaín, M., Moscou, M.J., Bhat, P.R., Svensson, J.T., Bartoš, J., Suchánková, P., Šimková, H., Endo, T.R., Fenton, R. D., Wu, Y., Lonardi, S., Castillo, A.M., Chao, S., Cistué, L., Cuesta-Marcos, A., Forrest, K., Hayden, M.J., Hayes, P.M., Horsley, R.D., Kleinhofs, A., Moody, D., Sato, K., Vallés, M.P., Wulff, B.B.H., Muehlbauer, G.J., Doležel, J., and Close, T.J. (2011)

An improved consensus linkage map of barley based on flow-sorted chromosomes and SNP markers. The Plant Genome. 4(3): 238-249.

Moscou, M.J., Lauter, N., Steffenson, B., and Wise, R.P. (2011)

Quantitative and qualitative stem rust resistance factors in barley are associated with transcriptional suppression of defense regulons. PLoS Genetics 7(7): e1002208.

Moscou, M.J., Lauter, N., Caldo, R.A., Nettleton, D., and Wise, R.P. (2011).

Quantitative and temporal definition of the Mla transcriptional regulon during barley-powdery mildew interactions. Molecular Plant-Microbe Interactions 24(6): 694-705.

Moscou, M.J. and Bogdanove, A. (2009)

A Simple Cipher Governs DNA Recognition by TAL Effectors. Science 326: 1501.

Job History

2014 – present Group Leader, The Sainsbury Laboratory, Norwich, UK.

2013 – 2014 Team Leader, The Sainsbury Laboratory, Norwich, UK.

2010 – 2012 Research Associate, The Sainsbury Laboratory, Norwich, UK.

Dr Matthew Moscou

Publications

Mascher M, Wicker T, Jenkins J, Plott C, Lux T, Koh CS, Ens J, Gundlach H, Boston LB, Tulpová Z, Holden S, Hernández-Pinzón I, Scholz U, Mayer KFX, Spannagl M, Pozniak CJ, Sharpe AG, Šimková H, Moscou MJ, Grimwood J, Schmutz J, Stein N (2021)

Białas A, Langner T, Harant A, Contreras MP, Stevenson CEM, Lawson DM, Sklenar J, Kellner R, Moscou MJ, Terauchi R, Banfield MJ, Kamoun S (2020)

Panstruga R, Moscou MJ (2020)

Read AC, Hutin M, Moscou MJ, Rinaldi FC, Bogdanove AJ (2020)

Read AC, Hutin M, Moscou MJ, Rinaldi FC, Bogdanove AJ (2020)

Wei B, Moscou MJ, Sato K, Gourlie R, Strelkov S, Aboukhaddour R (2020)

Hiebert CW, Moscou MJ, Hewitt T, Steuernagel B, Hernández-Pinzón I, Green P, Pujol C, Zhang P, Rouse MN, Jin Y, McIntosh RA, Upadhyayac N, Zhang J, Bhavani S, Jan Vrána J, Karafiátová M, Huang L, Fetch T, Doležel J, Wulff BH, Lagudah E, Spielmeyer W (2020)

Read AC, Moscou MJ, Zimin AV, Pertea G, Meyer RS, Purugganan MD, Leach JE, Triplett LR, Salzberg SL, Bogdanove AJ (2020)

Read AC, Moscou MJ, Zimin AV, Pertea G, Meyer RS, Purugganan MD, Leach JE, Triplett LR, Salzberg SL, Bogdanove AJ (2019)

Gilbert B, Bettgenhaeuser J, Upadhyaya N, Soliveres M, Singh D, Park RF, Moscou MJ, Ayliffe M (2018)

Bettgenhaeuser J, Gardiner M, Spanner R, Green P, Hernández-Pinzón I, Hubbard A, Ayliffe M, Moscou MJ (2018)

Omidvar V, Dugyala S, Li F, Rottschaefer S, Miller M, Ayliffe M, Moscou MJ, Kianian SF, Figueroa M (2018)

Bailey PC, Schudoma C, Jackson W, Baggs E, Dagdas G, Haerty W, Moscou M, Krasileva KV (2018)

Brabham HJ, Hernández-Pinzón I, Holden S, Lorang J, Moscou MJ (2017)

Moscou MJ, van Esse HP (2017)

Herb D, Filichkin T, Fisk S, Helgerson L, Hayes P, Benson A, Vega V, Carey D, Thiel R, Cistue L, Jennings R, Monsour R, Tynan S, Vinkemeier K, Li Y, Nguygen A, Onio A, Meints B, Moscou M, Romagosa I, Thomas W (2017)

Herb D, Filichkin F, Fisk S, Helgerson L, Hayes P, Meints B, Jennings R, Monsour R, Tynan S, Vinkemeier K, Romagosa I, Moscou M, Carey D, Thiel R, Cistue L, Martens C, Thomas W (2017)

Bailey PC, Schudoma C, Jackson W, Baggs E, Dagdas G, Haerty W, Moscou M, Krasileva KV (2017)

Yu G, Champouret N, Steuernagel B, Olivera PD, Simmons J, Williams C, Johnson R, Moscou MJ, Hernández-Pinzón I, Green P, Sela H, Millet E, Jones JD, Ward ER, Steffenson BJ, Wulff BB (2017)

Hisano H, Meints B, Moscou MJ, Cistue L, Echávarri B, Sato K, Hayes PM

Clare S, Kitcher W, Gardiner M, Green P, Hubbard A, Moscou MJ (2016)

Bettgenhaeuser J, Corke FM, Opanowicz M, Green P, Hernández-Pinzón I, Doonan JH, Moscou MJ (2016)

Le Fevre R, O'Boyle B, Moscou MJ, Schornack S (2016)

Dawson AM, Ferguson JN, Gardiner M, Green P, Hubbard A, Moscou MJ (2015)

Dawson AM, Bettgenhaeuser J, Gardiner M, Green P, Hernández-Pinzón I, Hubbard A, Moscou MJ (2015)

Knight E, Binnie A, Draeger T, Moscou M, Rey MD, Sucher J, Mehra S, King I, Moore G (2015)

Wulff BH and Moscou MJ (2014)

Bettgenhaeuser J, Gilbert B, Ayliffe M, Moscou MJ (2014)

Ayliffe, M. Singh, D., Park, R., Moscou, M., Pryor, T. (2013)

Bouyioukos c., Moscou M. J., Champouret N., Hernández-Pinzón I., Ward E. R. and Wulff B.B. H. (2013).

Moscou, M.J., Lauter, N., Steffenson, B., and Wise, R.P. (2011)

Moscou, M.J., Lauter, N., Caldo, R.A., Nettleton, D., and Wise, R.P. (2011).

Moscou, M.J. and Bogdanove, A. (2009)

Job History

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