I completed my PhD in Molecular Genetics at The University of Exeter in 2009, working with Trichoderma hamatum for use as a crop stimulant and biocontrol agent in plant agriculture. My interest in plant pathology moved me to Professor Nick Talbot’s Molecular Genetics group as an associate research fellow, where I could study the mechanisms required for the rice blast fungus Magnaporthe oryzae to infect rice. I am particularly interested in answering fundamental questions regarding the processes underling appressorium mediated plant infection in M. oryzae. My research interests have largely focused on the role of superoxide-generating NADPH enzymes in the formation and function of appressoria and subsequent host penetration by the rice blast fungus. I am currently determining what signal(s) triggers cytoskeletal reorientation during appressorium development prior to host entry. This could potentially identify a novel and broad mechanism of appressorium mediated plant infection in other important cereal diseases.
Lauren.Ryder@tsl.ac.uk
+44 (0) 1603 450415
Magnaporthe oryzae SMO1 encodes a Ras GTPase-activating protein required for spore morphology, appressorium function and rice blast disease. bioRxiv preprint Aug 08, 2018 doi: https://doi.org/10.1101/388298
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The MoT3 assay does not distinguish between Magnaporthe oryzae wheat and rice blast isolates from Bangladesh. bioRxiv preprint Jun 14, 2018 doi: https://doi.org/10.1101/345215
Read moreTowards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo.
Tpc1 is an important Zn(II)2Cys6 transcriptional regulator required for polarized growth and virulence in the rice blast fungus. PLoS Pathog. 2017 Jul 24;13(7):e1006516. doi: 10.1371/journal.ppat.1006516.
The role of glycerol in the pathogenic lifestyle of the rice blast fungus Magnaporthe oryzae. Environ Microbiol. 2017 Mar;19(3):1008-1016. doi: 10.1111/1462-2920.13688.
Investigating the biology of plant infection by the rice blast fungus Magnaporthe oryzae. Fungal Genet Biol. 2016 May;90:61-68. doi: 10.1016/j.fgb.2015.12.009.
Septin-Dependent Assembly of the Exocyst Is Essential for Plant Infection by Magnaporthe oryzae. The Plant Cell doi: http://dx.doi.org/10.1105/tpc.15.00552
Read moreRegulation of appressorium development in pathogenic fungi. Curr Opin Plant Biol. 2015 Aug;26:8-13. doi: 10.1016/j.pbi.2015.05.013
Identifying the emerging human pathogen Scedosporium prolificans by using a species-specific monoclonal antibody that binds to the melanin biosynthetic enzyme tetrahydroxynaphthalene reductase. Environ Microbiol. 2015 Apr;17(4):1023-38. doi: 10.1111/1462-2920.12470.
Investigating the beneficial traits of Trichoderma hamatum GD12 for sustainable agriculture-insights from genomics. Front Plant Sci. 2013 Jul 30;4:258. doi: 10.3389/fpls.2013.00258.
NADPH oxidases regulate septin-mediated cytoskeletal remodeling during plant infection by the rice blast fungus. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3179-84. doi: 10.1073/pnas.1217470110
Saprotrophic competitiveness and biocontrol fitness of a genetically modified strain of the plant-growth-promoting fungus Trichoderma hamatum GD12. Microbiology. 2012 Jan;158(Pt 1):84-97. doi: 10.1099/mic.0.051854-0.
Septin-mediated plant cell invasion by the rice blast fungus, Magnaporthe oryzae. Science. 2012 Jun 22;336(6088):1590-5. doi: 10.1126/science.1222934.
Effector-mediated suppression of chitin-triggered immunity by Magnaporthe oryzae is necessary for rice blast disease. Plant Cell. 2012 Jan;24(1):322-35. doi: 10.1105/tpc.111.092957.
2018 – present Senior Postdoctoral Scientist, The Sainsbury Laboratory, Norwich, UK
2013 – 2018 Senior Postdoctoral Scientist, University of Exeter, UK
2009 – 2013 Postdoctoral Scientist, University of Exeter, UK
2005 – 2009 PhD Student, University of Exeter, UK