Lauren Ryder

Senior Postdoctoral Scientist and Research Manager
Nick Talbot Group

I completed my PhD in Molecular Genetics at The University of Exeter in 2009, working with Trichoderma hamatum for use as a crop stimulant and biocontrol agent in plant agriculture. My interest in plant pathology moved me to Professor Nick Talbot’s Molecular Genetics group as an associate research fellow, where I could study the mechanisms required for the rice blast fungus Magnaporthe oryzae to infect rice. I am particularly interested in answering fundamental questions regarding the processes underling appressorium mediated plant infection in M. oryzae. My research interests have largely focused on the role of superoxide-generating NADPH enzymes in the formation and function of appressoria and subsequent host penetration by the rice blast fungus. I am currently determining what signal(s) triggers cytoskeletal reorientation during appressorium development prior to host entry. This could potentially identify a novel and broad mechanism of appressorium mediated plant infection in other important cereal diseases.


He M, Su J, Xu Y, Chen J, Chern M, Lei M, Qi T, Wang Z, Ryder LS, Tang B, Osés-Ruiz M, Zhu K, Cao Y, Yan X, Eisermann I, Luo Y, Li W, Wang J, Yin J, Lam SM, Peng G, Sun X, Zhu X, Ma B, Wang J, Liu J, Qing H, Song L, Wang L, Hou Q, Qin P, Li Y, Fan J, Li D, Wang Y, Wang X, Jiang L, Shui G, Xia Y, Gong G, Huang F, Wang W, Wu X, Li P, Zhu L, Li S, Talbot NJ, Chen X (2020)

Discovery of broad-spectrum fungicides that block septin-dependent infection processes of pathogenic fungi. Nat Microbiol. 2020 Sep 21. doi: 10.1038/s41564-020-00790-y.

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Liu C, Xing J, Cai X, Hendy A, He W, Yang J, Huang J, Peng YL, Ryder L, Chen XL (2020)

GPI7-mediated Glycosylphosphatidylinositol (GPI) Anchoring Regulates Appressorial Penetration and Immune Evasion during Infection of Magnaporthe oryzae. Environ Microbiol. 2020 Feb 16. doi: 10.1111/1462-2920.14941.

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Ryder LS, Dagdas YF, Kershaw MJ, Venkataraman C, Madzvamuse A, Yan, X Cruz-Mireles N, Soanes DM, Oses-Ruiz M, Styles V, Sklenar J, Menke FLH, Talbot NJ (2019)

A sensor kinase controls turgor-driven plant infection by the rice blast fungus. Nature 09 Oct 2019. doi:

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Kershaw MJ, Basiewicz M, Soanes DM, Yan X, Ryder LS, Csukai M, Oses-Ruiz M, Valent B, Talbot NJ (2018)

Conidial Morphogenesis and Septin-Mediated Plant Infection Require Smo1, a Ras GTPase-Activating Protein in Magnaporthe oryzae. Genetics. 2018 Nov 16. pii: genetics.301490.2018. doi: 10.1534/genetics.118.301490.

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Gupta DR, Avila CR, Win J, Soanes DM, Ryder LS, Croll D, Bhattacharjee P, Hossain MS, Mahmud NU, Mehebub MS, Surovy MZ, Rahman MM, Talbot N, Kamoun S, Islam MT (2018)

Cautionary Notes on Use of the MoT3 Diagnostic Assay for Magnaporthe oryzae Wheat and Rice Blast Isolates. Phytopathology. 2018 Sep 25. doi: 10.1094/PHYTO-06-18-0199-LE.

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Kershaw MJ, Basiewicz M, Soanes D, Yan X, Ryder LS, Csukai M, Valent B, Talbot N (2018)

Magnaporthe oryzae SMO1 encodes a Ras GTPase-activating protein required for spore morphology, appressorium function and rice blast disease. bioRxiv preprint Aug 08, 2018 doi:

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Gupta DR, Reyes-Avila CS, Win J, Soanes DM, Ryder LS, Daniel Croll D, Bhattacharjee P, Hossain MS, Mahmud NU, Mehbub MS, Surovy MZ, Talbot NJ, Kamoun S, Islam MT (2018)

The MoT3 assay does not distinguish between Magnaporthe oryzae wheat and rice blast isolates from Bangladesh. bioRxiv preprint Jun 14, 2018 doi:

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Davies G, Rolle AM, Maurer A, Spycher PR, Schillinger C, Solouk-Saran D, Hasenberg M, Weski J, Fonslet J, Dubois A, Boschetti F, Denat F, Gunzer M, Eichner M, Ryder LS, Jensen M, Schibli R, Pichler BJ, Wiehr S, Thornton CR (2017)

Towards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo.

Galhano R, Illana A, Ryder LS, Rodríguez-Romero J, Demuez M, Badaruddin M, Martinez-Rocha AL, Soanes DM, Studholme DJ, Talbot NJ, Sesma A (2017)

Tpc1 is an important Zn(II)2Cys6 transcriptional regulator required for polarized growth and virulence in the rice blast fungus. PLoS Pathog. 2017 Jul 24;13(7):e1006516. doi: 10.1371/journal.ppat.1006516.

Foster AJ, Ryder L, Kershaw MJ, Talbot NJ (2017)

The role of glycerol in the pathogenic lifestyle of the rice blast fungus Magnaporthe oryzae. Environ Microbiol. 2017 Mar;19(3):1008-1016. doi: 10.1111/1462-2920.13688.

Martin-Urdiroz M, Oses-Ruiz M, Ryder LS, Talbot NJ (2016)

Investigating the biology of plant infection by the rice blast fungus Magnaporthe oryzae. Fungal Genet Biol. 2016 May;90:61-68. doi: 10.1016/j.fgb.2015.12.009.

Gupta YK, Dagdas YF, Martinez-Rochaa A-L, Kershaw MJ, Littlejohn GR, Rydera LS, Sklenar J, Menke F, Talbot NJ (2015)

Septin-Dependent Assembly of the Exocyst Is Essential for Plant Infection by Magnaporthe oryzae. The Plant Cell doi: http:/​/​dx.​doi.​org/​10.​1105/​tpc.​15.​00552

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Ryder LS, Talbot NJ (2015)

Regulation of appressorium development in pathogenic fungi. Curr Opin Plant Biol. 2015 Aug;26:8-13. doi: 10.1016/j.pbi.2015.05.013

Thornton CR, Ryder LS, Le Cocq K, Soanes DM (2014)

Identifying the emerging human pathogen Scedosporium prolificans by using a species-specific monoclonal antibody that binds to the melanin biosynthetic enzyme tetrahydroxynaphthalene reductase. Environ Microbiol. 2015 Apr;17(4):1023-38. doi: 10.1111/1462-2920.12470.

Studholme DJ, Harris B, Le Cocq K, Winsbury R, Perera V, Ryder L, Ward JL, Beale MH, Thornton CR, Grant M (2013)

Investigating the beneficial traits of Trichoderma hamatum GD12 for sustainable agriculture-insights from genomics. Front Plant Sci. 2013 Jul 30;4:258. doi: 10.3389/fpls.2013.00258.

Ryder LS, Dagdas YF, Mentlak TA, Kershaw MJ, Thornton CR, Schuster M, Chen J, Wang Z, Talbot NJ (2013)

NADPH oxidases regulate septin-mediated cytoskeletal remodeling during plant infection by the rice blast fungus. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3179-84. doi: 10.1073/pnas.1217470110

Ryder LS, Harris BD, Soanes DM, Kershaw MJ, Talbot NJ, Thornton CR (2012)

Saprotrophic competitiveness and biocontrol fitness of a genetically modified strain of the plant-growth-promoting fungus Trichoderma hamatum GD12. Microbiology. 2012 Jan;158(Pt 1):84-97. doi: 10.1099/mic.0.051854-0.

Dagdas YF, Yoshino K, Dagdas G, Ryder LS, Bielska E, Steinberg G, Talbot NJ (2012)

Septin-mediated plant cell invasion by the rice blast fungus, Magnaporthe oryzae. Science. 2012 Jun 22;336(6088):1590-5. doi: 10.1126/science.1222934.

Mentlak TA, Kombrink A, Shinya T, Ryder LS, Otomo I, Saitoh H, Terauchi R, Nishizawa Y, Shibuya N, Thomma BP, Talbot NJ (2012)

Effector-mediated suppression of chitin-triggered immunity by Magnaporthe oryzae is necessary for rice blast disease. Plant Cell. 2012 Jan;24(1):322-35. doi: 10.1105/tpc.111.092957.

Job History

2018 – present Senior Postdoctoral Scientist, The Sainsbury Laboratory, Norwich, UK

2013 – 2018 Senior Postdoctoral Scientist, University of Exeter, UK

2009 – 2013 Postdoctoral Scientist, University of Exeter, UK

2005 – 2009 PhD Student, University of Exeter, UK