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Dr Ksenia Krasileva

Group Leader
Ksenia Krasileva Group

My group studies fundamental principles of plant innate immunity and the use of genomics in basic and translational research. We focus on wheat, a grass highly amenable to laboratory research and of immense importance in food security and human health. Recent advances in sequencing technologies are opening new frontiers in wheat. Draft sequence of wheat genome, availability of TILLING populations and CRISPR technologies allow for pathway dissection and engineering of favourable traits in short time span. My interests include advancing functional genomics in wheat and applying them to generate increased resistance to wheat pathogens. This group is formed by partnership of The Genome Analysis Centre (Triticeae Genomics) and The Sainsbury Laboratory.

Publications

Sarris PF, Volkan Cevik V, Gulay Dagdas G, Jones JDG, Krasileva KV (2016)

Comparative analysis of plant immune receptor architectures uncovers host proteins likely targeted by pathogens. BMC Biology (2016) 14:8 DOI 10.1186/s12915-016-0228-7

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Petre B, Saunders DGO, Sklenar J, Lorrain C, Krasileva KV, Win J, Duplessis S, Kamoun S (2016)

Heterologous Expression Screens in Nicotiana benthamiana Identify a Candidate Effector of the Wheat Yellow Rust Pathogen that Associates with Processing Bodies. PLoS ONE, February 10, 2016 doi: 10.1371/journal.pone.0149035

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Petre B, Saunders DGO, Sklenar J, Lorrain C, Krasileva KV, Win j, Duplessis D, Kamoun S (2015)

In planta expression screens of candidate effector proteins from the wheat yellow rust fungus reveal processing bodies as a pathogen-targeted plant cell compartment. bioRxiv preprint November 19, 2015 doi: http://dx.doi.org/10.1101/032276

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Schwessinger B, Bart R, Krasileva KV, Coaker G (2015)

Editorial article – Focus issue on plant immunity: from model systems to crop species. Front Plant Sci. 2015 Mar 26;6:195. doi: 10.3389/fpls.2015.00195.

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Wu C-H, Krasileva KV, Banfield MJ, Terauchi R, Kamoun S (2015)

The “sensor domains” of plant NLR proteins: more than decoys? Front. Plant Sci. doi: 10.3389/fpls.2015.00134

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Henry IM, Nagalakshmi U, Lieberman MC, Ngo KJ, Krasileva KV, Vasquez-Gross H, Akhunova A, Akhunov E, Dubcovsky J, Tai TH, Comai L (2014)

Efficient Genome-Wide Detection and Cataloging of EMS-Induced Mutations Using Exome Capture and Next-Generation Sequencing. Plant Cell. 2014 Apr 11;26(4):1382-1397.

Krasileva KV, Buffalo V, Bailey P, Pearce S, Ayling S, Tabbita F, Soria M, Wang S; IWGS Consortium, Akhunov E, Uauy C, Dubcovsky J (2013)

Separating homeologs by phasing in the tetraploid wheat transcriptome. Genome Biology 2013, 14:R66.

Steinbrenner AD, Goritschnig S, Krasileva KV, Schreiber KJ, Staskawicz BJ (2012)

Effector Recognition and Activation of the Arabidopsis thaliana NLR Innate Immune Receptors. Cold Spring Harbor Symposia on Quant. Biol. 77:249-257.

Bart R, Cohn M, Kassen A, McCallum EJ, Shybut M, Petriello A, Krasileva K, Dahlbeck D, Medina C, Alicai T, Kumar L, Moreira LM, Rodrigues Neto J, Verdier V, Santana MA, Kositcharoenkul N, Vanderschuren H, Gruissem W, Bernal A, Staskawicz BJ (2012)

High-throughput genomic sequencing of cassava bacterial blight strains identifies conserved effectors to target for durable resistance. Proceeding of National Academy of Sciences U S A, 109(28):E1972-9.

Goritschnig S, Krasileva KV, Dahlbeck D, Staskawicz BJ (2012)

Computational prediction and molecular characterization of an oomycete effector and the cognate Arabidopsis resistance gene. PLoS Genetics 8(2):e1002502.

Win J, Krasileva KV, Kamoun S, Shirasu K, Staskawicz BJ, Banfield MJ (2012)

Sequence divergent RXLR effectors share a structural fold conserved across plant pathogenic oomycete species. PLoS Pathogens, 8:e1002400.

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Krasileva KV, Zheng C, Leonelli L, Goritschnig S, Dahlbeck D, Staskawicz BJ (2011)

Global analysis of Arabidopsis/downy mildew interactions reveals prevalence of incomplete resistance and rapid evolution of pathogen recognition. PLoS One, 6: e28765.

Zhao B, Dahlbeck D, Krasileva KV, Fong RW, Staskawicz BJ (2011)

Computational and biochemical analysis of the Xanthomonas effector AvrBs2 and its role in the modulation of Xanthomonas type three effector delivery. PLoS Pathogens. 12 :e1002408.

Chou S*, Krasileva KV*, Holton JM, Steinbrenner AD, Alber T, Staskawicz BJ (2011) *equal contribution

Hyaloperonospora arabidopsidis ATR1 effector is a repeat protein with distributed recognition surfaces. Proceeding of National Academy of Sciences U S A. 108(32): 13323-8.

Potnis N*, Krasileva K*, Chow V, Almeida NF, Patil PB, Ryan RP, Sharlach M, Behlau F, Dow JM, Momol M, White FF, Preston JF, Vinatzer BA, Koebnik R, Setubal JC, Norman DJ, Staskawicz BJ, Jones JB (2011) *equal contribution

Comparative genomics reveals diversity among xanthomonads infecting tomato and pepper. BMC Genomics, 12(1): 146.

Krasileva KV, Dahlbeck D, Staskawicz BJ (2010)

Activation of an Arabidopsis resistance protein is specified by the in planta association of its leucine-rich repeat domain with the cognate oomycete effector. Plant Cell, 22:1-16.

Dulla GF, Krasileva KV, Lindow SE (2010)

Interference of quorum sensing in Pseudomonas syringae by bacterial epiphytes that limit iron availability. Environ Microbiol. 2010 Jun;12(6):1762-74. doi: 10.1111/j.1462-2920.2010.02261.x.

Win J, Morgan W, Bos J, Krasileva KV, Cano LM, Chaparro-Garcia A, Ammar R, Staskawicz BJ, Kamoun S (2007)

Adaptive evolution has targeted the C-terminal domain of the RXLR effectors of plant pathogenic oomycetes. Plant Cell 19, 2349-2369.

Job History

2014 – present Group Leader, The Genome Analysis Centre/The Sainsbury Lab

2011 – 2014 Post doctoral scholar, USDA AFRI-NIFA Fellow, University of California, Davis (mentor: Jorge Dubcovsky)

2005 – 2011 Graduate Student Researcher, University of California, Berkeley (mentor: Brian J Staskawicz)

2003 – 2005 Undergraduate Student Researcher, University of California, Berkeley (mentor: Steven E Lindow)