Back

Dr Hailong Guo

Postdoctoral Scientist
Jonathan Jones Group

Plant immunity is triggered upon pathogen detection by dedicated immune receptors. Like animal Nod-like receptors (NLRs), plant immune receptors have a modular structure and can work in pairs, both of which are required for defence activation upon recognition of specific pathogen effectors. Arabidopsis RPS4/RRS1 is such a two-component plant immune receptor complex, which recognizes diverse pathogen effectors. RRS1B/RPS4B, an R gene pair paralogous and closely linked to RRS1/RPS4, also recognizes effector AvrRps4. Using the RPS4/RRS1 and RPS4B/RRS1B systems, I aim to understand how paired NLRs function to detect pathogens and initiate immunity related signalling.

hailong.guo@tsl.ac.uk
+44 (0) 1603 450326

Publications

Ma Y, Guo H, Hu L, Martinez PP, Moschou PN, Cevik V, Ding P, Duxbury Z, Sarris PF, Jones JDG (2018)

Distinct modes of derepression of an Arabidopsis immune receptor complex by two different bacterial effectors. Proc Natl Acad Sci U S A. 2018 Sep 25. pii: 201811858. doi: 10.1073/pnas.1811858115.

Read more

Ding P, Guo H, Jones JDG (2018)

Deadlier than the malate. Cell Res. 2018 May 29. doi: 10.1038/s41422-018-0042-6.

Feng P, Guo H, Chi W, Chai X, Sun X, Xu X, Ma J, Rochaix JD, Leister D, Wang H, Lu C, Zhang L (2016)

Chloroplast retrograde signal regulates flowering. Proc Natl Acad Sci U S A. 113:10708-13. doi: 10.1073/pnas.1521599113.

Guo H, Feng P, Chi W, Sun X, Xu X, Li Y, Ren D, Lu C, Rochaix JD, Leister D, Zhang L (2016)

Plastid-nucleus communication involves calcium-modulated MAPK signalling. Nat Commun. 7:12173. doi: 10.1038/ncomms12173.

Xu X, Chi W, Sun X, Feng P, Guo H, Li J, Lin R, Lu C, Wang H, Leister D, Zhang L (2016)

Convergence of light and chloroplast signals for de-etiolation through ABI4-HY5 and COP1. Nat Plants. 2:16066. doi: 10.1038/nplants.2016.66.

Sun X, Feng P, Xu X, Guo H, Ma J, Chi W, Lin R, Lu C, Zhang L (2011)

A chloroplast envelope-bound PHD transcription factor mediates chloroplast signals to the nucleus. Nat Commun. 2:477. doi: 10.1038/ncomms1486.

Job History

2016 – present Postdoctoral Scientist, The Sainsbury Laboratory, Norwich, UK.

2009 – 2016 PhD Student, Chinese Academy of Science, Beijing, China

2005 – 2009 Undergraduate Student, Southwest University, Chongqing, China