Dr Hailong Guo

Postdoctoral Scientist
Jonathan Jones Group

Plant immunity is triggered upon pathogen detection by dedicated immune receptors. Like animal Nod-like receptors (NLRs), plant immune receptors have a modular structure and can work in pairs, both of which are required for defence activation upon recognition of specific pathogen effectors. Arabidopsis RPS4/RRS1 is such a two-component plant immune receptor complex, which recognizes diverse pathogen effectors. RRS1B/RPS4B, an R gene pair paralogous and closely linked to RRS1/RPS4, also recognizes effector AvrRps4. Using the RPS4/RRS1 and RPS4B/RRS1B systems, I aim to understand how paired NLRs function to detect pathogens and initiate immunity related signalling.
+44 (0) 1603 450326


Ding P, Guo H, Jones JDG (2018)

Deadlier than the malate. Cell Res. 2018 May 29. doi: 10.1038/s41422-018-0042-6.

Feng P, Guo H, Chi W, Chai X, Sun X, Xu X, Ma J, Rochaix JD, Leister D, Wang H, Lu C, Zhang L (2016)

Chloroplast retrograde signal regulates flowering. Proc Natl Acad Sci U S A. 113:10708-13. doi: 10.1073/pnas.1521599113.

Guo H, Feng P, Chi W, Sun X, Xu X, Li Y, Ren D, Lu C, Rochaix JD, Leister D, Zhang L (2016)

Plastid-nucleus communication involves calcium-modulated MAPK signalling. Nat Commun. 7:12173. doi: 10.1038/ncomms12173.

Xu X, Chi W, Sun X, Feng P, Guo H, Li J, Lin R, Lu C, Wang H, Leister D, Zhang L (2016)

Convergence of light and chloroplast signals for de-etiolation through ABI4-HY5 and COP1. Nat Plants. 2:16066. doi: 10.1038/nplants.2016.66.

Sun X, Feng P, Xu X, Guo H, Ma J, Chi W, Lin R, Lu C, Zhang L (2011)

A chloroplast envelope-bound PHD transcription factor mediates chloroplast signals to the nucleus. Nat Commun. 2:477. doi: 10.1038/ncomms1486.

Job History

2016 – present Postdoctoral Scientist, The Sainsbury Laboratory, Norwich, UK.

2009 – 2016 PhD Student, Chinese Academy of Science, Beijing, China

2005 – 2009 Undergraduate Student, Southwest University, Chongqing, China