Hiroaki Adachi

Postdoctoral Scientist
Sophien Kamoun Group

I am interested in plant-pathogen interaction, and especially in signalling after pathogen sensing to induce plant immune responses. During my PhD, I focused on MAPK cascade-mediated signalling pathway to understand how plants trigger hypersensitive response (HR) including ROS burst and localized cell death.

My current project focuses on understanding molecular mechanism how NLR proteins sense cognate effectors and initiate downstream signaling to induce HR.


Wu CH, Adachi H, Concepcion JC, Castells-Graells R, Nekrasov V, Kamoun S (2019)

A CRISPR/Cas9 mediated 53 kb deletion of the NRC4 gene cluster of tomato does not affect bacterial flagellin-triggered immunity. bioRxiv preprint Jul 10, 2019 doi:

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Adachi H, Contreras M, Harant A, Wu CH, Derevnina L, Sakai T, Duggan C, Moratto E, Bozkurt T, Maqbool A, Win J, Kamoun S (2019)

An N-terminal motif in NLR immune receptors is functionally conserved across distantly related plant species. bioRxiv preprint Jul 04, 2019 doi:

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Adachi H, Derevnina L, Kamoun S (2019)

NLR singletons, pairs, and networks: evolution, assembly, and regulation of the intracellular immunoreceptor circuitry of plants. Curr Opin Plant Biol. 2019 May 30;50:121-131. doi: 10.1016/j.pbi.2019.04.007.

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Adachi H, Kamoun S, Maqbool A (2019)

A resistosome-activated ‘death switch’. Nat Plants. 2019 Apr 29. doi: 10.1038/s41477-019-0425-9.

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Adachi H, Tsuda K (2019)

Commentary: Convergence of cell‐surface and intracellular immune receptor signalling. New Phytologist 221: 1676-1678.

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Yoshioka H, Adachi H, Nakano T, Miyagawa N, Ishihama N, Asai S, Yoshioka M (2016)

Hierarchical regulation of NADPH oxidase by protein kinases in plant immunity. Physiol. Mol. Plant Pathol. 95, 20-16.

Adachi H, Ishihama N, Nakano T, Yoshioka M, Yoshioka H (2016)

Nicotiana benthamiana MAPK-WRKY pathway confers resistance to a necrotrophic pathogen Botrytis cinerea. Plant Signal Behav. 2016 Jun 2;11(6):e1183085. doi: 10.1080/15592324.2016.1183085.

Adachi H, Nakano T, Miyagawa N, Ishihama N, Yoshioka M, Katou Y, Yaeno T, Shirasu K, Yoshioka H (2015)

WRKY Transcription Factors Phosphorylated by MAPK Regulate a Plant Immune NADPH Oxidase in Nicotiana benthamiana. Adachi H, Nakano T, Miyagawa N, Ishihama N, Yoshioka M, Katou Y, Yaeno T, Shirasu K, Yoshioka H

Le Roux C, Huet G, Jauneau A, Camborde L, Trémousaygue D, Kraut A, Zhou B, Levaillant M, Adachi H, Yoshioka H, Raffaele S, Berthomé R, Couté Y, Parker JE, Deslandes L (2015)

A receptor pair with an integrated decoy converts pathogen disabling of transcription factors to immunity. Cell. 2015 May 21;161(5):1074-88. doi: 10.1016/j.cell.2015.04.025.

Adachi H, Yoshioka H (2015)

Kinase-mediated orchestration of NADPH oxidase in plant immunity. Brief Funct Genomics. 2015 Jul;14(4):253-9. doi: 10.1093/bfgp/elv004.

Ishihama N, Adachi H, Yoshioka M, Yoshioka H (2014)

In vivo phosphorylation of WRKY transcription factor by MAPK. “Plant MAP Kinases: Methods and Protocols”, In Methods in Molecular Biology, Vol. 1171, (Komis, G. and Samaj, J. eds) Springer/Humana Press, NY, pp. 171-181.

Job History

2017 – present Postdoctoral Scientist, The Sainsbury Laboratory, UK

2014 – 2017 PhD Student, Magoya University, Japan