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Dr Chih-Hang Wu

Postdoctoral Scientist
Sophien Kamoun Group

I am interested in understanding the interaction between plants and filamentous pathogens at cell biology, biochemistry and genetics levels.

My current project focuses on how solanaceous NB-LRR immune receptors recognize cognate effectors and mediate downstream signalling which lead to disease resistance. The current approach is to use immunoprecipitation and mass spectrometry to identify proteins which associate with immune receptors, and then study to what extent that these associated proteins contribute to plant immunity.

I truly believe that our understanding about plant immune receptors could provide fundamental knowledge to maintain durable disease resistance in importance crops in agriculture.

Publications

Bialas A, Zess EK, De la Concepcion JC, Franceschetti M, Pennington HG, Yoshida K, Upson JL, Chanclud E, Wu C-H, Langner T, Maqbool A, Varden FA, Derevnina L, Belhaj K, Fujisaki K, Saitoh H, Terauchi R, Banfield MJ, Kamoun S (2017)

Lessons in effector and NLR biology of plant-microbe systems. bioRxiv preprint Aug 2, 2017 doi: https://doi.org/10.1101/171223

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Wu CH, Abd-El-Haliem A, Bozkurt TO, Belhaj K, Terauchi R, Vossen JH, Kamoun S (2017)

NLR network mediates immunity to diverse plant pathogens. Proc Natl Acad Sci U S A. 2017 Jul 11. pii: 201702041. doi: 10.1073/pnas.1702041114.

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Wu CH, Abd-El-Haliem A, Bozkurt TO, Belhaj K, Terauchi R, Vossen JH, Kamoun S (2016)

NLR signaling network mediates immunity to diverse plant pathogens. bioRxiv preprint November 29, 2016 doi: http://dx.doi.org/10.1101/090449

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Derevnina L, Dagdas YF, De la Concepcion JC, Bialas A, Kellner R, Petre B, Domazakis E, Du J, Wu CH, Lin X, Aguilera-Galvez C, Cruz-Mireles N, Vleeshouwers VG, Kamoun S (2016)

Nine things to know about elicitins. New Phytol. 2016 Sep 1. doi: 10.1111/nph.14137.

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Wu CH, Belhaj K, Bozkurt TO, Birk MS, Kamoun S (2015)

Helper NLR proteins NRC2a/b and NRC3 but not NRC1 are required for Pto-mediated cell death and resistance in Nicotiana benthamiana. New Phytol. 2015 Nov 23. doi: 10.1111/nph.13764.

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Wu C-H, Belhaj K, Bozkurt TO, Kamoun S (2015)

The NLR helper protein NRC3 but not NRC1 is required for Pto-mediated cell death in Nicotiana benthamiana. bioRxiv doi: http://dx.doi.org/10.1101/015479

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Bozkurt TO, Belhaj K, Dagdas YF, Chaparro-Garcia A, Wu CH, Cano LM, Kamoun S (2014)

Rerouting of plant late endocytic trafficking towards a pathogen interface. Traffic. 2014 Nov 28. doi: 10.1111/tra.12245. [Epub ahead of print]

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Wu, C. H., Lee, S. C., and Wang, C. W. 2011.

Viral protein targeting to the cortical endoplasmic reticulum is required for cell-cell spreading in plants. Journal of Cell Biology, 193: 521-535.

Lee, S. C., Wu, C. H., and Wang, C. W. 2010.

Traffic of a viral movement protein complex to the highly curved tubules of the cortical endoplasmic reticulum. Traffic. 11: 912-930.

Wu, C. H., Yan, H. Z., Liu, L. F., and Liou, R. F. 2008.

Functional characterization of a gene family encoding polygalacturonases in Phytophthora parasitica. Mol. Plant-Microbe Interact. 21: 480-489.

Job History

2016 – present Postodoctoral Scientist, The Sainsbury Laboratory, Norwich, UK

2012 – 2016 PhD Student, The Sainsbury Laboratory, Norwich, UK.

2011 – 2012 Research Assistant, National Taiwan University, Taiwan.

2008 – 2011 Research Assistant, Institute of Plant and Microbial Biology, Academia Sinica, Taiwan.

2005 – 2007 MSc Student, National Taiwan University, Taiwan.

2001 – 2005 BSc Student,┬áNational Taiwan University, Taiwan.