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Dr Angela Chaparro-Garcia

Postdoctoral Scientist
Sophien Kamoun Group

My goal is to translate basic research discoveries in plant-microbe interactions into applied solutions to overcome critical agricultural challenges, in particular disease resistance. I am interested in developing new technologies to improve agricultural sustainability and food security.

Publications

Derevnina L, Petre B, Kellner R, Dagdas YF, Sarowar MN, Giannakopoulou A, De la Concepcion JC, Chaparro-Garcia A, Pennington HG, van West P, Kamoun S (2016)

Emerging oomycete threats to plants and animals. Philos Trans R Soc Lond B Biol Sci. 2016 Dec 5;371(1709). pii: 20150459. doi: 10.1098/rstb.2015.0459.

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Giannakopoulou A, Chaparro-Garcia A, Kamoun S (2016)

The potato NLR immune receptor R3a does not contain non-canonical integrated domains. bioRxiv preprint May 31, 2016 doi: http://dx.doi.org/10.1101/056242

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Dagdas YF, Belhaj K, Maqbool A, Chaparro-Garcia A, Pandey P, Petre B, Tabassum N, Cruz-Mireles N, Hughes RK, Sklenar J, Win J, Menke F, Findlay K, Banfield MJ, Kamoun S, Bozkurt TO

An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor. Elife. 2016 Jan 14;5. pii: e10856. doi: 10.7554/eLife.10856

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Chaparro-Garcia A, Kamoun S, Nekrasov V (2015)

Boosting plant immunity with CRISPR/Cas. Genome Biol. 2015 Nov 19;16(1):254.

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Chaparro-Garcia A, Schwizer S, Sklenar J, Yoshida K, Petre B, Bos JI, Schornack S, Jones AM, Bozkurt TO, Kamoun S (2015)

Phytophthora infestans RXLR-WY Effector AVR3a Associates with Dynamin-Related Protein 2 Required for Endocytosis of the Plant Pattern Recognition Receptor FLS2. PLoS One;10(9):e0137071. doi: 10.1371/journal.pone.0137071.

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Du J, Verzaux E, Chaparro-Garcia A, Bijsterbosch G, Keizer LCP, Zhou J, Liebrand TWH, Xie C, Govers F, Robatzek S, van der Vossen EAG, Jacobsen E, Visser RGF, Kamoun S, Vleeshouwers VGAA (2015)

Elicitin recognition confers enhanced resistance to Phytophthora infestans in potato. Nature Plants 1, Article number: 15034 (2015) ​doi:10.1038/nplants.2015.34

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Belhaj K, Chaparro-Garcia A, Kamoun S, Patron NJ, Nekrasov V (2015)

Editing plant genomes with CRISPR/Cas9. Current Opinion in Biotechnology Volume 32, April 2015, Pages 76–84

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Bozkurt TO, Belhaj K, Dagdas YF, Chaparro-Garcia A, Wu CH, Cano LM, Kamoun S (2014)

Rerouting of plant late endocytic trafficking towards a pathogen interface. Traffic. 2014 Nov 28. doi: 10.1111/tra.12245. [Epub ahead of print]

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Segretin, M.E., Pais, M., Franceschetti, M., Chaparro-Garcia, A., Bos, J.I., Banfield, M.J., and Kamoun, S. (2014)

Single amino acid mutations in the potato immune receptor R3a expand response to Phytophthora effectors. Molecular Plant-Microbe Interactions, in press.

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Belhaj, K., Chaparro-Garcia, A., Kamoun, S. and Nekrasov, V. (2013)

Plant genome editing made easy: targeted mutagenesis in model and crop plants using the CRISPR/Cas system. Plant Methods, 9:39.

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Win, J., Chaparro-Garcia, A., Belhaj, K., Saunders, D.G.O., Yoshida, K., Dong, S., Schornack, S., Zipfel, C., Robatzek, S., Hogenhout, S.A., and Kamoun, S. 2012.

Effector Biology of Plant-associated Organisms: Concepts and Perspectives. Cold Spring Harbor Symposium on Quantitative Biology, 77:235-247.

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Chaparro-Garcia, A., Wilkinson, R.C., Gimenez-Ibanez, S., Findlay, K., Coffey, M.D., Zipfel, C., Rathjen, J.P., Kamoun, S., and Schornack, S. 2011.

The receptor-like kinase SERK3/BAK1 is required for basal resistance against the late blight pathogen Phytophthora infestans in Nicotiana benthamiana. PLoS One, 6:e16608.

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Yaeno, T., Li, H., Chaparro-Garcia, A., Schornack, S., Koshiba, S., Watanabe, S., Kigawa, T., Kamoun, S., and Shirasu, K. 2011.

Phosphatidylinositol monophosphate-binding interface in the oomycete RXLR effector AVR3a is required for its stability in host cells to modulate plant immunity. Proceedings of the National Academy of Sciences USA, 108:14682-14687.

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Win J, Morgan W, Bos J, Krasileva KV, Cano LM, Chaparro-Garcia A, Ammar R, Staskawicz BJ, Kamoun S (2007)

Adaptive evolution has targeted the C-terminal domain of the RXLR effectors of plant pathogenic oomycetes. Plant Cell 19, 2349-2369.

Job History

2013 – present Postdoctoral Scientist, The Sainsbury Laboratory, Norwich, UK.

2008 – 2012 PhD Student, The Sainsbury Laboratory & University of East Anglia, Norwich, UK.

2007 – 2008 Research Assistant, Dept. of Biological Sciences, University of Buffalo, New York, USA.

2006 – 2007 Visiting Scholar, Dept. of Plant Pathology, The Ohio State University, USA.

2006 Undergraduate Intern, Dept. de Ciencias Biológicas, Laboratorio de Micología y Fitopatologia (LAMFU), Universidad de los Andes, Bogota, Colombia.