Sophien Kamoun

Project Leader

Contact details

Email: sophien.kamoun@sainsbury-laboratory.ac.uk

Research interests

Unravelling the biochemical activities of effectors to understand how pathogens successfully colonize and reproduce on their host plants has become the driving paradigm in the field of plant pathology. We study effector biology, mainly in the Phytophthora infestans-Solanaceae pathosystem. Our long-term objective is to dissect the molecular mechanisms that enable filamentous pathogens, such as the oomycete P. infestans, to successfully infect plants and the plant processes that are perturbed by the effectors of this pathogen. We aim at understanding how pathogen effectors function, how they evolve, and how they traffic into host cells.

Selected Publications

  • Raffaele, S., and Kamoun, S. 2012. Genome evolution in filamentous plant pathogens: why bigger can be better. Nature Reviews Microbiology, 10:417-430.
  • Bozkurt, T.O., Schornack, S., Banfield, M.J., and Kamoun, S. 2012. Oomycetes, effectors, and all that jazz. Current Opinion in Plant Biology, in press.
  • Win, J., Krasileva, K.V., Kamoun, S., Shirasu, K., Staskawicz, B.J., and Banfield, M.J. 2012. Sequence divergent RXLR effectors share a structural fold conserved across plant pathogenic oomycete species. PLoS Pathogens, 8:e1002400.
  • MacLean, D., and Kamoun, S. 2012. Big data in small places. Nature Biotechnology, 30:33-34.
  • Vleeshouwers, V.G.A.A., Raffaele, R., Vossen, J., Champouret, N., Oliva, R., Segretin, M.E., Rietman, H., Cano, L.M., Lokossou, A., Kessel, G., Pel, M.A., and Kamoun, S. 2011. Understanding and exploiting late blight resistance in the age of effectors. Annual Reviews of Phytopathology, 49:507-531.
  • Thines, M., and Kamoun, S. 2010. Oomycete-plant coevolution: recent advances and future prospects. Current Opinion in Plant Biology, 13:427-433.
  • Oliva, R., Win, J., Raffaele, S., Boutemy, L., Bozkurt, T.O., Chaparro-Garcia, A., Segretin, M.E., Stam, R., Schornack, S., Cano, L.M., van Damme, M., Huitema, E., Thines, M., Banfield, M.J., and Kamoun, S. 2010. Recent developments in effector biology of filamentous plant pathogens. Cellular Microbiology, 12:705-715.
  • Schornack, S., Huitema, E., Cano, L.M., Bozkurt, T.O., Oliva, R., van Damme, M., Schwizer, S., Raffaele, S., Chaparro-Garcia, A., Farrer, R., Segretin, M.E., Bos, J., Haas, B.J., Zody, M.C., Nusbaum, C., Win, J., Thines, M., and Kamoun, S. 2009. Ten things to know about oomycete effectors. Molecular Plant Pathology, 10:795-803.
  • Hogenhout, S.A., Van der Hoorn, R.A.L., Terauchi, R., and Kamoun, S. 2009. Emerging concepts in effector biology of plant-associated organisms. Molecular Plant-Microbe Interactions, 22:115-122.
  • Van der Hoorn, R.A. and Kamoun, S. 2008. From guard to decoy: a new model for perception of plant pathogen effectors. Plant Cell, 20:2009-2017.
  • Morgan, W., and Kamoun, S. 2007. RXLR effectors of plant pathogenic oomycetes. Current Opinion in Microbiology, 10:332-338.
  • Kamoun, S. 2007. Groovy times: filamentous pathogen effectors revealed. Current Opinion in Plant Biology, 10:358-365.
  • Birch, P. R. J., Rehmany, A. P., Pritchard, L., Kamoun, S., and Beynon, J. L. 2006. Trafficking arms: oomycete effectors enter host plant cells. Trends in Microbiology, 14:8-11.
  • Kamoun, S. 2006. A catalogue of the effector secretome of plant pathogenic oomycetes. Annual Review of Phytopathology, 44: 41-60.
  • Haldar, K., Kamoun, S., Hiller, L. N., Bhattacharjee, S., and and van Ooij, C. 2006. Common infection strategies of pathogenic eukaryotes. Nature Reviews Microbiology, 4:922-931.
  • Kamoun, S., and Smart, C.D. 2005. Late blight of potato and tomato in the genomics era. Plant Disease, 89:692-699.
  • Kamoun, S. 2003. Molecular genetics of pathogenic oomycetes. Eukaryotic Cell, 2:191-199.