Cyril Zipfel

Project Leader

Contact details

Email: cyril.zipfel@sainsbury-laboratory.ac.uk

Research interests

We are using a combination of forward- and reverse-genetics, as well as biochemical and proteomic approaches to answer the main questions underlying our research programme:

 

  • How are pamp perceived?
  • What are the signalling events downstream of pamp perception?
  • What is the contribution of pamp perception to plant immunity?

Selected Publications

Kadota Y, Sklenar J, Derbyshire P, Stransfeld L, Asai S, Ntoukakis V, Jones JDG, Shirasu K, Menke FL, Jones A and Zipfel C (2014) Direct regulation of the NADPH oxidase RBOHD by the PRR-associated kinase BIK1 during plant immunity.Molecular Cell, 54 (1): 43-55.

Macho AP, Schwessinger B, Ntoukakis V, Brutus A, Segonzac C, Roy S, Kadota Y, Oh MH, Sklenar J, Derbyshire P, Lozano-Duran R, Gro Malinovsky F, Monaghan J, Menke FL, Huber SC, He SY and Zipfel C (2014) A bacterial tyrosine phosphatase inhibits plant pattern recognition receptor activation. Science, 343 (6178): 1509-1512.

Lozano-Duran R, Macho A, Boutrot F, Segonzac C, Somssich IE and Zipfel C (2013) The transcriptional regulator BZR1 mediates trade-off between plant innate immunity and growth. eLIFE, 2(0):e00983.

Nicaise V, Joe A, Jeong B, Korneli C, Boutrot F, Westedt I, Staiger D, Alfano J and Zipfel C (2013) Pseudomonas HopU1 modulates plant immune receptor levels by blocking the interaction of their mRNAs with GRP7. EMBO J, 32:701-712.

Schwessinger B, Roux M, Kadota Y, Ntoukakis V, Sklenar J, Jones AM and Zipfel C (2011)Phosphorylation-dependent differential regulation of plant growth, cell death and innate immunity by the regulatory receptor-like kinase BAK1. PLoS Genetics, 7(4): e1002046.

Roux M, Schwessinger B, Albrecht C, Chinchilla D, Jones AM, Holton N, Malinovsky F, Tör M, de Vries S and Zipfel C (2011) The Arabidopsis leucine-rich repeat receptor-like kinases BAK1/SERK3 and BKK1/SERK4 are required for innate immunity to hemibiotrophic and biotrophic pathogens. Plant Cell, 23: 2440-2455.

Lacombe S, Rougon-Cardoso A, Sherwood E, Peeters N, Dahlbeck D, van Esse HP, Smoker M, Rallapalli G,Thomma BPHJ, Staskawicz B, Jones JDG and Zipfel C(2010) Inter-family transfer of a plant pattern recognition receptor confers broad-spectrum bacterial resistance. Nature Biotechnology, 4 :365-369.