We are using a combination of forward- and reverse-genetics, as well as biochemical and proteomic approaches to answer the main questions underlying our research programme:
- How are pamp perceived?
- What are the signalling events downstream of pamp perception?
- What is the contribution of pamp perception to plant immunity?
Kadota Y, Sklenar J, Derbyshire P, Stransfeld L, Asai S, Ntoukakis V, Jones JDG, Shirasu K, Menke FL, Jones A and Zipfel C (2014) Direct regulation of the NADPH oxidase RBOHD by the PRR-associated kinase BIK1 during plant immunity.Molecular Cell, 54 (1): 43-55.
Macho AP, Schwessinger B, Ntoukakis V, Brutus A, Segonzac C, Roy S, Kadota Y, Oh MH, Sklenar J, Derbyshire P, Lozano-Duran R, Gro Malinovsky F, Monaghan J, Menke FL, Huber SC, He SY and Zipfel C (2014) A bacterial tyrosine phosphatase inhibits plant pattern recognition receptor activation. Science, 343 (6178): 1509-1512.
Lozano-Duran R, Macho A, Boutrot F, Segonzac C, Somssich IE and Zipfel C (2013) The transcriptional regulator BZR1 mediates trade-off between plant innate immunity and growth. eLIFE, 2(0):e00983.
Nicaise V, Joe A, Jeong B, Korneli C, Boutrot F, Westedt I, Staiger D, Alfano J and Zipfel C (2013) Pseudomonas HopU1 modulates plant immune receptor levels by blocking the interaction of their mRNAs with GRP7. EMBO J, 32:701-712.
Schwessinger B, Roux M, Kadota Y, Ntoukakis V, Sklenar J, Jones AM and Zipfel C (2011)Phosphorylation-dependent differential regulation of plant growth, cell death and innate immunity by the regulatory receptor-like kinase BAK1. PLoS Genetics, 7(4): e1002046.
Roux M, Schwessinger B, Albrecht C, Chinchilla D, Jones AM, Holton N, Malinovsky F, Tör M, de Vries S and Zipfel C (2011) The Arabidopsis leucine-rich repeat receptor-like kinases BAK1/SERK3 and BKK1/SERK4 are required for innate immunity to hemibiotrophic and biotrophic pathogens. Plant Cell, 23: 2440-2455.
Lacombe S, Rougon-Cardoso A, Sherwood E, Peeters N, Dahlbeck D, van Esse HP, Smoker M, Rallapalli G,Thomma BPHJ, Staskawicz B, Jones JDG and Zipfel C(2010) Inter-family transfer of a plant pattern recognition receptor confers broad-spectrum bacterial resistance. Nature Biotechnology, 4 :365-369.