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Our group studies the molecular basis of plant innate immunity. We aim at deciphering the signaling events linking perception of pathogen-associated molecular patterns (PAMPs) to the establishment of immunity.

We use the leucine-rich repeats receptor kinases EFR and FLS2, which perceive bacterial EF-Tu and flagellin, respectively, as model pattern recognition receptors (PRRs).

Our work also aims at understanding how plant receptor kinases work at the molecular level and how signaling specificity is achieved between different receptor kinase-mediated signaling pathways involved in immunity and growth.

We are also exploring how outcomes of our research can be used to engineer sustainable broad-spectrum disease resistance in crops.

The Zipfel group is based both at TSL and at the University of Zurich (Switzerland) (https://www.botinst.uzh.ch/en/research/plantsensing/zipfel.html).  In addition to our own research, we also collaborate with researchers across TSL and contribute to joint research programmes.

Latest Publications

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Gronnier J, Franck CM, Stegmann M, DeFalco TA, Cifuentes AA, Dünser K, Lin W, Yang Z, Kleine-Vehn J, Ringli C, Zipfel C (2020)

FERONIA regulates FLS2 plasma membrane nanoscale dynamics to modulate plant immune signaling. bioRxiv preprint July 22, 2020 doi: https://doi.org/10.1101/2020.07.20.212233

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Abarca A, Franck CM, Zipfel C (2020)

Family-wide evaluation of RALF peptides in Arabidopsis thaliana. bioRxiv preprint June 27, 2020 doi: https://doi.org/10.1101/2020.06.26.174169

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Kato H, Onai K, Abe A, Shimizu M, Takagi H, Tateda C, Utsushi H, Singkarabanit-Ogawa S, Kitakura S, Ono E, Zipfel C, Takano Y, Ishiura M, Terauchi R (2020)

Lumi-Map, a real-time luciferase bioluminescence screen of mutants combined with MutMap, reveals Arabidopsis genes involved in PAMP-triggered immunity. bioRxiv preprint May 12, 2020 doi: https://doi.org/10.1101/2020.05.11.086728

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Noble JA, Liu MCJ, DeFalco TA, Stegmann M, McNamara K, Sullivan B, Dinh KK, Khuu N, Hancock S, Shiu SH, Zipfel C, Beilstein MA, Cheung AY, Palanivelu R (2020)

Conserved Molecular Function and Regulatory Subfunctionalization of the LORELEI Gene Family in Brassicaceae. bioRxiv preprint Apr 29, 2020 doi: https://doi.org/10.1101/2020.04.27.062893

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