Cyril Zipfel Group
Our group studies the molecular basis of plant innate immunity. We aim at deciphering the signaling events linking perception of pathogen-associated molecular patterns (PAMPs) to the establishment of immunity.
We use the leucine-rich repeats receptor kinases EFR and FLS2, which perceive bacterial EF-Tu and flagellin, respectively, as model pattern recognition receptors (PRRs).
Our work also aims at understanding how plant receptor kinases work at the molecular level and how signaling specificity is achieved between different receptor kinase-mediated signaling pathways involved in immunity and growth.
We are also exploring how outcomes of our research can be used to engineer sustainable broad-spectrum disease resistance in crops.
Perraki A, DeFalco TA, Derbyshire P, Avila J, Séré D, Sklenar J, Qi X, Stransfeld L, Schwessinger B, Kadota Y, Macho AP, Jiang S, Couto D, Torii KU, Menke FLH, Zipfel C (2018)
Phosphocode-dependent functional dichotomy of a common co-receptor in plant signalling. Nature, 3 Sept 2018. doi: 10.1038/s41586-018-0471-xRead more
Pfeilmeier S, George J, Morel A, Roy S, Smoker M, Stransfeld L, Downie JA, Peeters N, Malone JG, Zipfel C (2018)
Expression of the Arabidopsis thaliana immune receptor EFR in Medicago truncatula reduces infection by a root pathogenic bacterium, but not nitrogen-fixing rhizobial symbiosis. Plant Biotechnol J. 2018 Aug 18. doi: 10.1111/pbi.12999.Read more
Engelsdorf T, Gigli-Bisceglia N, Veerabagu M, McKenna JF, Vaahtera L, Augstein F, Van der Does D, Zipfel C, Hamann T (2018)
The plant cell wall integrity maintenance and immune signaling systems cooperate to control stress responses in Arabidopsis thaliana. Sci Signal. 2018 Jun 26;11(536). pii: eaao3070. doi: 10.1126/scisignal.aao3070.Read more
Kunwar S, Iriarte F, Fan Q, da Silva EE, Ritchie L, Nguyen NS, Freeman JH, Stall RE, Jones JB, Minsavage GV, Colee J, Scott J, Vallad GE, Zipfel C, Horvath D, Westwood J, Hutton S, Paret ML (2018)
Transgenic expression of EFR and Bs2 genes for field management of bacterial wilt and bacterial spot of tomato. Phytopathology. 2018 Jun 20. doi: 10.1094/PHYTO-12-17-0424-R.Read more