Cyril Zipfel Group
Our group studies the molecular basis of plant innate immunity. We aim at deciphering the signaling events linking perception of pathogen-associated molecular patterns (PAMPs) to the establishment of immunity.
We use the leucine-rich repeats receptor kinases EFR and FLS2, which perceive bacterial EF-Tu and flagellin, respectively, as model pattern recognition receptors (PRRs).
Our work also aims at understanding how plant receptor kinases work at the molecular level and how signaling specificity is achieved between different receptor kinase-mediated signaling pathways involved in immunity and growth.
We are also exploring how outcomes of our research can be used to engineer sustainable broad-spectrum disease resistance in crops.
Engelsdorf T, Gigli-Bisceglia N, Veerabagu M, McKenna JF, Vaahtera L, Augstein F, Van der Does D, Zipfel C, Hamann T (2018)
The plant cell wall integrity maintenance and immune signaling systems cooperate to control stress responses in Arabidopsis thaliana. Sci Signal. 2018 Jun 26;11(536). pii: eaao3070. doi: 10.1126/scisignal.aao3070.Read more
Kunwar S, Iriarte F, Fan Q, da Silva EE, Ritchie L, Nguyen NS, Freeman JH, Stall RE, Jones JB, Minsavage GV, Colee J, Scott J, Vallad GE, Zipfel C, Horvath D, Westwood J, Hutton S, Paret ML (2018)
Transgenic expression of EFR and Bs2 genes for field management of bacterial wilt and bacterial spot of tomato. Phytopathology. 2018 Jun 20. doi: 10.1094/PHYTO-12-17-0424-R.Read more
Amorim-Silva V, Garcia-Moreno A, Castillo AG, Lakhssassi N, Perez-Sancho J, Li Y, Esteban del Valle A, Pose D, Perez-Rodriguez J, Lin J, Valpuesta V, Borsani O, Zipfel C, Macho AP, Botella MA (2018)
TTL proteins scaffold brassinosteroid signaling components at the plasma membrane to optimize signal transduction in plant cells. bioRxiv preprint Jun 20, 2018 doi: https://doi.org/10.1101/351056Read more
Bender KW, Zipfel C (2018)
Plant G-protein activation: connecting to plant receptor kinases. Cell Res. 2018 May 29. doi: 10.1038/s41422-018-0046-2.Read more