Cyril Zipfel Group
Our group studies the molecular basis of plant innate immunity. We aim at deciphering the signaling events linking perception of pathogen-associated molecular patterns (PAMPs) to the establishment of immunity.
We use the leucine-rich repeats receptor kinases EFR and FLS2, which perceive bacterial EF-Tu and flagellin, respectively, as model pattern recognition receptors (PRRs).
Our work also aims at understanding how plant receptor kinases work at the molecular level and how signaling specificity is achieved between different receptor kinase-mediated signaling pathways involved in immunity and growth.
We are also exploring how outcomes of our research can be used to engineer sustainable broad-spectrum disease resistance in crops.
Xiao Y, Stegmann M, Han Z, DeFalco TA, Parys K, Xu L, Belkhadir Y, Zipfel C, Chai J (2019)
Mechanisms of RALF peptide perception by a heterotypic receptor complex. Nature 10th July 2019. doi: 10.1038/s41586-019-1409-7Read more
Wong JEMM, Nadzieja M, Madsen LH, Bücherl CA, Dam S, Sandal NN, Couto D, Derbyshire P, Uldum-Berentsen M, Schroeder S, Schwämmle V, Nogueira FCS, Asmussen MH, Thirup S, Radutoiu S, Blaise M, Andersen KR, Menke FLH, Zipfel C, Stougaard J (2019)
A Lotus japonicus cytoplasmic kinase connects Nod factor perception by the NFR5 LysM receptor to nodulation. Proc Natl Acad Sci U S A. 2019 Jun 25. pii: 201815425. doi: 10.1073/pnas.1815425116.Read more
Steinbrenner AD, Muñoz-Amatriaín M, Venegas JMA, Lo S, Shi D, Holton N, Zipfel C, Abagyan R, Huffaker A, Close TJ, Schmelz EA (2019)
A receptor for herbivore-associated molecular patterns mediates plant immunity. bioRxiv preprint Jun 22, 2019 doi: https://doi.org/10.1101/679803Read more
Amorim-Silva V, Garcia-Moreno A, Castillo AG, Lakhssassi N, Esteban Del Valle A, Perez-Sancho J, Li Y, Pose D, Perez-Rodriguez J, Lin J, Valpuesta V, Borsani O, Zipfel C, Macho AP, Botella MA (2019)
TTL proteins scaffold brassinosteroid signaling components at the plasma membrane to optimize signal transduction in Arabidopsis. Plant Cell. 2019 Jun 12. pii: tpc.00150.2019. doi: 10.1105/tpc.19.00150.Read more