Cyril Zipfel Group
Our group studies the molecular basis of plant innate immunity. We aim at deciphering the signaling events linking perception of pathogen-associated molecular patterns (PAMPs) to the establishment of immunity.
We use the leucine-rich repeats receptor kinases EFR and FLS2, which perceive bacterial EF-Tu and flagellin, respectively, as model pattern recognition receptors (PRRs).
Our work also aims at understanding how plant receptor kinases work at the molecular level and how signaling specificity is achieved between different receptor kinase-mediated signaling pathways involved in immunity and growth.
We are also exploring how outcomes of our research can be used to engineer sustainable broad-spectrum disease resistance in crops.
The Zipfel group is based both at TSL and at the University of Zurich (Switzerland) (https://www.botinst.uzh.ch/en/research/plantsensing/zipfel.html). In addition to our own research, we also collaborate with researchers across TSL and contribute to joint research programmes.
Kato H, Onai K, Abe A, Shimizu M, Takagi H, Tateda C, Utsushi H, Singkarabanit-Ogawa S, Kitakura S, Ono E, Zipfel C, Takano Y, Ishiura M, Terauchi R (2020)
Lumi-Map, a real-time luciferase bioluminescence screen of mutants combined with MutMap, reveals Arabidopsis genes involved in PAMP-triggered immunity. bioRxiv preprint May 12, 2020 doi: https://doi.org/10.1101/2020.05.11.086728Read more
Noble JA, Liu MCJ, DeFalco TA, Stegmann M, McNamara K, Sullivan B, Dinh KK, Khuu N, Hancock S, Shiu SH, Zipfel C, Beilstein MA, Cheung AY, Palanivelu R (2020)
Conserved Molecular Function and Regulatory Subfunctionalization of the LORELEI Gene Family in Brassicaceae. bioRxiv preprint Apr 29, 2020 doi: https://doi.org/10.1101/2020.04.27.062893Read more
Cheval C, Samwald S, Johnston MG, de Keijzer J, Breakspear A, Liu X, Bellandi A, Kadota Y, Zipfel C, Faulkner C (2020)
Chitin perception in plasmodesmata characterizes submembrane immune-signaling specificity in plants. Proc Natl Acad Sci U S A. 2020 Apr 13. pii: 201907799. doi: 10.1073/pnas.1907799117.Read more
Cheung AY, Qu LJ, Russinova E, Zhao Y, Zipfel C (2020)
Update on Receptors and Signaling. Plant Physiol. 2020 Apr;182(4):1527-1530. doi: 10.1104/pp.20.00275.Read more