Cyril Zipfel Group
Our group studies the molecular basis of plant innate immunity. We aim at deciphering the signaling events linking perception of pathogen-associated molecular patterns (PAMPs) to the establishment of immunity.
We use the leucine-rich repeats receptor kinases EFR and FLS2, which perceive bacterial EF-Tu and flagellin, respectively, as model pattern recognition receptors (PRRs).
Our work also aims at understanding how plant receptor kinases work at the molecular level and how signaling specificity is achieved between different receptor kinase-mediated signaling pathways involved in immunity and growth.
We are also exploring how outcomes of our research can be used to engineer sustainable broad-spectrum disease resistance in crops.
Lammertz M, Kuhn H, Pfeilmeier S, Malone JG, Zipfel C, Kwaaitaal M, Lin NC, Kvitko BH, Panstruga R (2019)
Widely-conserved attenuation of plant MAMP-induced calcium influx by bacteria depends on multiple virulence factors and may involve desensitization of host pattern recognition receptors. Mol Plant Microbe Interact. 2019 Jan 21. doi: 10.1094/MPMI-10-18-0291-R.Read more
Galindo-Trigo S, Blanco-Tourinan N, DeFalco TA, Zipfel C, Gray JE, Smith LM (2018)
CrRLK1L receptor-like kinases HERK1 and ANJEA are female determinants of pollen tube reception. bioRxiv preprint Nov 19, 2018 doi: https://doi.org/10.1101/428854
Perraki A, Gronnier J, Gouguet P, Boudsocq M, Deroubaix AF, Simon V, German-Retana S, Zipfel C, Bayer E, Mongrand S, Germain V, Legrand A, Habenstein B (2018)
REM1.3’s phospho-status defines its plasma membrane nanodomain organization and activity in restricting PVX cell-to-cell movement. PLoS Pathog. 2018 Nov 12;14(11):e1007378. doi: 10.1371/journal.ppat.1007378.Read more
Kadota Y, Liebrand TWH, Goto Y, Sklenar J, Derbyshire P, Menke FLH, Torres MA, Molina A, Zipfel C, Coaker G, Shirasu K (2018)
Quantitative phosphoproteomic analysis reveals common regulatory mechanisms between effector- and PAMP-triggered immunity in plants. New Phytol. 2018 Oct 9. doi: 10.1111/nph.15523.Read more