Synthetic Biology at The Sainsbury Laboratory was formed in May 2013.
We design and develop molecular tools to engineer genomes and use natural and synthetic biological parts to produce novel functions in plant cells.
Our research is centred around the tools and methods for the precise modification of plant genomes, efficient high-order DNA assembly, and developing molecular tools that allow us to detect and understand the molecular interactions between plants and their pathogens.
Patron NJ (2016)
Blueprints for green biotech: development and application of standards for plant synthetic biology. Biochem Soc Trans. 44:702-8. doi: 10.1042/BST20160044.Read more
Parry G, Patron N, Bastow R, Matthewman C (2016)
Meeting report: GARNet/OpenPlant CRISPR-Cas workshop. Plant Methods 2016 12:6 DOI: 10.1186/s13007-016-0104-zRead more
Raitskin O, Patron NJ (2015)
Multi-gene engineering in plants with RNA-guided Cas9 nuclease. Curr Opin Biotechnol. 2015 doi: 10.1016/j.copbio.2015.11.008Read more
Lawrenson T, Shorinola O, Stacey N, Li C, Østergaard L, Patron N, Uauy C, Harwood W (2015)
Induction of targeted, heritable mutations in barley and Brassica oleracea using RNA-guided Cas9 nuclease. Genome Biology 2015, 16:258 doi:10.1186/s13059-015-0826-7Read more