Host membranes respond to pathogen perception and this underpins the molecular exchange between plants and pathogens important for the outcome of immunity. Pattern recognition receptors (PRRs) such as the flagellin receptor FLS2 are primary sensors of the plant’s immune system, presented at the plasma membrane to recognize pathogens and trigger immunity.

Focusing on how the secretory and endocytic trafficking network responds to microbial attack, research in my lab is dissecting the spatio-temporal redistribution of membranes and their cargoes following pathogen perception.

Our main research addresses how PRRs are transported through the cell: how this is regulated, how this contributes to PRR abundance control and thus how it regulates defence activation. An important aspect of plant defence is the dynamic closure of stomata, which is a particular interest to our research.

My lab uses quantitative high-throughput live-cell imaging combined with genetic and biochemical approaches to comprehensively dissect the endomembrane trafficking pathways revealing mechanistic and functional elements of PRR dynamics. This will be relevant for understanding the communication between plants and microbes and will provide novel solutions to crop improvement.

Latest Publications

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Meteignier LV, Zhou J, Cohen M, Bhattacharjee S, Brosseau C, Caamal Chan MG, Robatzek S, Moffett P (2016)

NB-LRR signaling induces translational repression of viral transcripts and the formation of RNA processing bodies through mechanisms differing from those activated by UV stress and RNAi. J. Exp. Bot. (2016) doi: 10.1093/jxb/erw042

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Petre B, Kopischke M, Evrard A, Robatzek S, Kamoun S (2016)

Cell re-entry assays do not support models of pathogen-independent translocation of AvrM and AVR3a effectors into plant cells. bioRxiv preprint January 29, 2016 doi:

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Abd-El-Haliem A, Vossen JH, van Zeijl A, Dezhsetan S, Testerink C, Seidl MF, Beck M, Strutt J, Robatzek S, Joosten MHAJ (2016)

Biochemical characterization of the tomato phosphatidylinositol-specific phospholipase C (PI-PLC) family and its role in plant immunity. Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids doi:10.1016/j.bbalip.2016.01.017

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Mithoe SC, Ludwig C, Pel MJC, Cucinotta M, Casartelli A, Mbengue M, Sklenar J, Derbyshire P, Robatzek S, Pieterse CMJ, Aebersold R, Menke FLH (2015)

Attenuation of pattern recognition receptor signaling is mediated by a MAP kinase kinase kinase. EMBO reports (2016). DOI 10.15252/embr.201540806

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