Host membranes respond to pathogen perception and this underpins the molecular exchange between plants and pathogens important for the outcome of immunity. Pattern recognition receptors (PRRs) such as the flagellin receptor FLS2 are primary sensors of the plant’s immune system, presented at the plasma membrane to recognize pathogens and trigger immunity.

Focusing on how the secretory and endocytic trafficking network responds to microbial attack, research in my lab is dissecting the spatio-temporal redistribution of membranes and their cargoes following pathogen perception.

Our main research addresses how PRRs are transported through the cell: how this is regulated, how this contributes to PRR abundance control and thus how it regulates defence activation. An important aspect of plant defence is the dynamic closure of stomata, which is a particular interest to our research.

My lab uses quantitative high-throughput live-cell imaging combined with genetic and biochemical approaches to comprehensively dissect the endomembrane trafficking pathways revealing mechanistic and functional elements of PRR dynamics. This will be relevant for understanding the communication between plants and microbes and will provide novel solutions to crop improvement.

Latest Publications

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Bücherl CA, Jarsch IK, Schudoma C, Segonzac C, Mbengue M, Robatzek S, MacLean D, Ott T, Zipfel C (2017)

Plant immune and growth receptors share common signalling components but localise to distinct plasma membrane nanodomains. eLife 2017;10.7554/eLife.25114

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Mbengue M, Bourdais G, Gervasi F, Beck M, Zhou J, Spallek T, Bartels S, Boller T, Ueda T, Kuhn H, Robatzek S (2016)

Clathrin-dependent endocytosis is required for immunity mediated by pattern recognition receptor kinases. Proc Natl Acad Sci U S A. 2016 Sep 20. pii: 201606004.

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Couto D, Niebergall R, Liang X, Bücherl CA, Sklenar J, Macho AP, Ntoukakis V, Derbyshire P, Altenbach D, Maclean D, Robatzek S, Uhrig J, Menke F, Zhou JM, Zipfel C (2016)

The Arabidopsis Protein Phosphatase PP2C38 Negatively Regulates the Central Immune Kinase BIK1. PLoS Pathog. 12(8):e1005811. doi: 10.1371/journal.ppat.1005811.

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Meteignier LV, Zhou J, Cohen M, Bhattacharjee S, Brosseau C, Caamal Chan MG, Robatzek S, Moffett P (2016)

NB-LRR signaling induces translational repression of viral transcripts and the formation of RNA processing bodies through mechanisms differing from those activated by UV stress and RNAi. J. Exp. Bot. (2016) doi: 10.1093/jxb/erw042

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