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The availability of genome sequences has revolutionized biology and in particular proteomics.

With the increasing speed and resolving power of the latest mass spectrometers, comprehensive proteome coverage has become a (not to distant) reality. However mapping the increasing numbers of post-translational modifications on the proteome and identifying protein-protein interactions in the context of host microbe interactions remains a formidable challenge that keeps us from truly understanding signal transduction and plant immunity from a network biology perspective.

The proteomics team at TSL addresses this challenge through collaborative projects using our new discovery proteomics platform, the Orbitrap Fusion from Thermo Fisher, and applying targeted proteomics approaches on our Xevo TSQ triple quadrupole (Waters).

Latest Publications

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Mithoe SC, Menke F (2018)

Regulation of pattern recognition receptor signalling by phosphorylation and ubiquitination. Curr Opin Plant Biol. 2018 Jul 28;45(Pt A):162-170. doi: 10.1016/j.pbi.2018.07.008.

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Bi G, Zhou Z, Wang W, Li L, Rao S, Wu Y, Zhang X, Menke FLH, Chen S, Zhou J-M (2018)

Receptor-like Cytoplasmic Kinases Directly Link Diverse Pattern Recognition Receptors to the Activation of Mitogen-activated Protein Kinase Cascades in Arabidopsis. The Plant Cell Jun 2018, tpc.00981.2017; DOI: 10.1105/tpc.17.00981

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Petre B, Win J, Menke FLH, Kamoun S (2017)

Protein-Protein Interaction Assays with Effector-GFP Fusions in Nicotiana benthamiana. Methods Mol Biol. 2017;1659:85-98. doi: 10.1007/978-1-4939-7249-4_8.

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Wirthmueller L, Asai S, Rallapalli G, Sklenar J, Fabro G, Kim DS, Lintermann R, Jaspers P, Wrzaczek M, Kangasjärvi L, MacLean D, Menke FLH, Banfield MJ, JDG (2017)

An Oomycete Effector Protein Induces Shade Avoidance In Arabidopsis And Attenuates Salicylate Signaling By Binding To Host Proteins Of The RADICAL-INDUCED CELL DEATH1 Family. bioRxiv preprint May 14, 2017 doi: https://doi.org/10.1101/137844

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