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The availability of genome sequences has revolutionized biology and in particular proteomics.

With the increasing speed and resolving power of the latest mass spectrometers, comprehensive proteome coverage has become a (not to distant) reality. However mapping the increasing numbers of post-translational modifications on the proteome and identifying protein-protein interactions in the context of host microbe interactions remains a formidable challenge that keeps us from truly understanding signal transduction and plant immunity from a network biology perspective.

The proteomics team at TSL addresses this challenge through collaborative projects using our new discovery proteomics platform, the Orbitrap Fusion from Thermo Fisher, and applying targeted proteomics approaches on our Xevo TSQ triple quadrupole (Waters).

Latest Publications

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Ryder LS, Dagdas YF, Kershaw MJ, Venkataraman C, Madzvamuse A, Yan, X Cruz-Mireles N, Soanes DM, Oses-Ruiz M, Styles V, Sklenar J, Menke FLH, Talbot NJ (2019)

A sensor kinase controls turgor-driven plant infection by the rice blast fungus. Nature 09 Oct 2019. doi: https://doi.org/10.1038/s41586-019-1637-x

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Liu Y, Maierhofer T, Rybak K, Sklenar J, Breakspear A, Johnston MG, Fliegmann J, Huang S, Roelfsema MRG, Felix G, Faulkner C, Menke FL, Geiger D, Hedrich R, Robatzek S (2019)

Anion channel SLAH3 is a regulatory target of chitin receptor-associated kinase PBL27 in microbial stomatal closure. Elife. 2019 Sep 16;8. pii: e44474. doi: 10.7554/eLife.44474.

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Zess EK, Jensen C, Cruz-Mireles N, De la Concepcion JC, Sklenar J, Stephani M, Imre R, Roitinger E, Hughes R, Belhaj K, Mechtler K, Menke FLH, Bozkurt T, Banfield MJ, Kamoun S, Maqbool A, Dagdas YF (2019)

N-terminal β-strand underpins biochemical specialization of an ATG8 isoform. PLoS Biol. 2019 Jul 22;17(7):e3000373. doi: 10.1371/journal.pbio.3000373.

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Wong JEMM, Nadzieja M, Madsen LH, Bücherl CA, Dam S, Sandal NN, Couto D, Derbyshire P, Uldum-Berentsen M, Schroeder S, Schwämmle V, Nogueira FCS, Asmussen MH, Thirup S, Radutoiu S, Blaise M, Andersen KR, Menke FLH, Zipfel C, Stougaard J (2019)

A Lotus japonicus cytoplasmic kinase connects Nod factor perception by the NFR5 LysM receptor to nodulation. Proc Natl Acad Sci U S A. 2019 Jun 25. pii: 201815425. doi: 10.1073/pnas.1815425116.

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