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The availability of genome sequences has revolutionized biology and in particular proteomics.

With the increasing speed and resolving power of the latest mass spectrometers, comprehensive proteome coverage has become a (not to distant) reality. However mapping the increasing numbers of post-translational modifications on the proteome and identifying protein-protein interactions in the context of host microbe interactions remains a formidable challenge that keeps us from truly understanding signal transduction and plant immunity from a network biology perspective.

The proteomics team at TSL addresses this challenge through collaborative projects using our new discovery proteomics platform, the Orbitrap Fusion from Thermo Fisher, and applying targeted proteomics approaches on our Xevo TSQ triple quadrupole (Waters).

Latest Publications

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Bender KW, Couto D, Kadota Y, Macho AP, Sklenar J, Derbyshire P, Bjornson M, DeFalco TA, Petriello A, Font Farre M, Schwessinger B, Ntoukakis V, Stransfeld L, Jones AME, Menke FLH, Cyril Zipfel C (2021)

Activation loop phosphorylaton of a non-RD receptor kinase initiates plant innate immune signaling. PNAS September 21, 2021 118 (38) e2108242118; https://doi.org/10.1073/pnas.2108242118

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Derevnina L, Contreras MP, Adachi H, Upson J, Vergara Cruces A, Xie R, Skłenar J, Menke FLH, Mugford ST, MacLean D, Ma W, Hogenhout S, Goverse A, Maqbool A, Wu CH, Kamoun S (2021)

Plant pathogens convergently evolved to counteract redundant nodes of an NLR immune receptor network. PLoS Biol. 2021 Aug 23;19(8):e3001136. doi: 10.1371/journal.pbio.3001136.

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Białas A, Langner T, Harant A, Contreras MP, Stevenson CE, Lawson DM, Sklenar J, Kellner R, Moscou MJ, Terauchi R, Banfield MJ, Kamoun S (2021)

Two NLR immune receptors acquired high-affinity binding to a fungal effector through convergent evolution of their integrated domain. Elife. 2021 Jul 21;10:e66961. doi: 10.7554/eLife.66961.

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Sun X, Lapin D, Feehan JM, Stolze SC, Kramer K, Dongus JA, Rzemieniewski J, Blanvillain-Baufumé S, Harzen A, Bautor J, Derbyshire P, Menke FLH, Finkemeier I, Nakagami H, Jones JDG, Parker JE (2021)

Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity. Nat Commun. 2021 Jun 7;12(1):3335. doi: 10.1038/s41467-021-23614-x.

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