The availability of genome sequences has revolutionized biology and in particular proteomics.
With the increasing speed and resolving power of the latest mass spectrometers, comprehensive proteome coverage has become a (not to distant) reality. However mapping the increasing numbers of post-translational modifications on the proteome and identifying protein-protein interactions in the context of host microbe interactions remains a formidable challenge that keeps us from truly understanding signal transduction and plant immunity from a network biology perspective.
The proteomics team at TSL addresses this challenge through collaborative projects using our new discovery proteomics platform, the Orbitrap Fusion from Thermo Fisher, and applying targeted proteomics approaches on our Xevo TSQ triple quadrupole (Waters).
Latest Group News
Zess EK, Jensen C, Cruz-Mireles N, De la Concepcion JC, Sklenar J, Stephani M, Imre R, Roitinger E, Hughes R, Belhaj K, Mechtler K, Menke FLH, Bozkurt T, Banfield MJ, Kamoun S, Maqbool A, Dagdas YF (2019)
N-terminal β-strand underpins biochemical specialization of an ATG8 isoform. PLoS Biol. 2019 Jul 22;17(7):e3000373. doi: 10.1371/journal.pbio.3000373.Read more
Wong JEMM, Nadzieja M, Madsen LH, Bücherl CA, Dam S, Sandal NN, Couto D, Derbyshire P, Uldum-Berentsen M, Schroeder S, Schwämmle V, Nogueira FCS, Asmussen MH, Thirup S, Radutoiu S, Blaise M, Andersen KR, Menke FLH, Zipfel C, Stougaard J (2019)
A Lotus japonicus cytoplasmic kinase connects Nod factor perception by the NFR5 LysM receptor to nodulation. Proc Natl Acad Sci U S A. 2019 Jun 25. pii: 201815425. doi: 10.1073/pnas.1815425116.Read more
Zess EK, Jensen C, Cruz-Mireles N, De la Concepcion JC, Sklenar J, Imre R, Roitinger E, Hughes R, Belhaj K, Mechtler K, Menke F, Bozkurt T, Banfield M, Kamoun S, Maqbool A, Dagdas Y (2018)
N-terminal β-strand underpins biochemical specialization of an ATG8 isoform. bioRxiv preprint Oct 25, 2018 doi: https://doi.org/10.1101/453563Read more
Kadota Y, Liebrand TWH, Goto Y, Sklenar J, Derbyshire P, Menke FLH, Torres MA, Molina A, Zipfel C, Coaker G, Shirasu K (2018)
Quantitative phosphoproteomic analysis reveals common regulatory mechanisms between effector- and PAMP-triggered immunity in plants. New Phytol. 2018 Oct 9. doi: 10.1111/nph.15523.Read more