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Matthew Moscou Group

Our research focuses on understanding the genetic architecture underlying host and nonhost resistance. We use natural and induced variation within host, intermediate host, and nonhost species to identify the genetic loci specifying resistance. Our efforts are concentrated on the cereal rusts and their interaction with several grass species, including wheat (Triticum aestivum), barley (Hordeum vulgare), oat (Avena sativa), and purple false brome (Brachypodium distachyon). We apply a suite of approaches to rapidly accelerate our research, including genetics, bioinformatics, molecular biology, and next-generation sequencing.

Current projects in the group include:

– Genetic architecture underlying host species specificity of stripe rust

– Multiple pathogen resistance specificity at the Mla locus

– Map-based cloning of adult plant resistance QTLs to barley stripe rust

– Distribution, diversity, and expression of the barley NB-LRRome

– Nonhost resistance in Brachypodium spp. to wheat stripe rust

– Suppression of resistance in polyploid genomes

 

Latest Publications

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Omidvar V, Dugyala S, Li F, Rottschaefer S, Miller M, Ayliffe M, Moscou MJ, Kianian SF, Figueroa M (2018)

Detection of race-specific resistance against Puccinia coronata f. sp. avenae in Brachypodium species. Phytopathology. 2018 Jun 20. doi: 10.1094/PHYTO-03-18-0084-R.

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Bailey PC, Schudoma C, Jackson W, Baggs E, Dagdas G, Haerty W, Moscou M, Krasileva KV (2018)

Dominant integration locus drives continuous diversification of plant immune receptors with exogenous domain fusions. Genome Biol. 2018 Feb 19;19(1):23. doi: 10.1186/s13059-018-1392-6.

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Brabham HJ, Hernández-Pinzón I, Holden S, Lorang J, Moscou MJ (2017)

An ancient integration in a plant NLR is maintained as a trans-species polymorphism. bioRxiv preprint Dec 25, 2017 doi: https://doi.org/10.1101/239541

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Moscou MJ, van Esse HP (2017)

The quest for durable resistance. Science: Vol. 358, Issue 6370, pp. 1541-1542 DOI: 10.1126/science.aar4797

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