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Matthew Moscou Group

Our research focuses on understanding the genetic architecture underlying host and nonhost resistance. We use natural and induced variation within host, intermediate host, and nonhost species to identify the genetic loci specifying resistance. Our efforts are concentrated on the cereal rusts and their interaction with several grass species, including wheat (Triticum aestivum), barley (Hordeum vulgare), oat (Avena sativa), and purple false brome (Brachypodium distachyon). We apply a suite of approaches to rapidly accelerate our research, including genetics, bioinformatics, molecular biology, and next-generation sequencing.

Current projects in the group include:

– Genetic architecture underlying host species specificity of stripe rust

– Multiple pathogen resistance specificity at the Mla locus

– Map-based cloning of adult plant resistance QTLs to barley stripe rust

– Distribution, diversity, and expression of the barley NB-LRRome

– Nonhost resistance in Brachypodium spp. to wheat stripe rust

– Suppression of resistance in polyploid genomes

 

Latest Publications

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Herb D, Filichkin T, Fisk S, Helgerson L, Hayes P, Benson A, Vega V, Carey D, Thiel R, Cistue L, Jennings R, Monsour R, Tynan S, Vinkemeier K, Li Y, Nguygen A, Onio A, Meints B, Moscou M, Romagosa I, Thomas W (2017)

Malt Modification and Its Effects on the Contributions of Barley Genotype to Beer Flavor. J. Am. Soc. Brew. Chem. 75(4):354-362, 2017.

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Herb D, Filichkin F, Fisk S, Helgerson L, Hayes P, Meints B, Jennings R, Monsour R, Tynan S, Vinkemeier K, Romagosa I, Moscou M, Carey D, Thiel R, Cistue L, Martens C, Thomas W (2017)

Effects of Barley (Hordeum vulgare L.) Variety and Growing Environment on Beer Flavor. J. Am. Soc. Brew. Chem. 75(4):345-353, 2017.

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Bailey PC, Schudoma C, Jackson W, Baggs E, Dagdas G, Haerty W, Moscou M, Krasileva KV (2017)

Dominant integration locus drives continuous diversification of plant immune receptors with exogenous domain fusions. bioRxiv preprint Aug 19, 2017 doi: https://doi.org/10.1101/100834

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Yu G, Champouret N, Steuernagel B, Olivera PD, Simmons J, Williams C, Johnson R, Moscou MJ, Hernández-Pinzón I, Green P, Sela H, Millet E, Jones JD, Ward ER, Steffenson BJ, Wulff BB (2017)

Discovery and characterization of two new stem rust resistance genes in Aegilops sharonensis. Theor Appl Genet. 2017 Mar 8. doi: 10.1007/s00122-017-2882-8.

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