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Matthew Moscou Group

Our research focuses on understanding the genetic architecture underlying host and nonhost resistance. We use natural and induced variation within host, intermediate host, and nonhost species to identify the genetic loci specifying resistance. Our efforts are concentrated on the cereal rusts and their interaction with several grass species, including wheat (Triticum aestivum), barley (Hordeum vulgare), oat (Avena sativa), and purple false brome (Brachypodium distachyon). We apply a suite of approaches to rapidly accelerate our research, including genetics, bioinformatics, molecular biology, and next-generation sequencing.

Current projects in the group include:

– Genetic architecture underlying host species specificity of stripe rust

– Multiple pathogen resistance specificity at the Mla locus

– Map-based cloning of adult plant resistance QTLs to barley stripe rust

– Distribution, diversity, and expression of the barley NB-LRRome

– Nonhost resistance in Brachypodium spp. to wheat stripe rust

– Suppression of resistance in polyploid genomes

 

Latest Publications

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Mascher M, Wicker T, Jenkins J, Plott C, Lux T, Koh CS, Ens J, Gundlach H, Boston LB, Tulpová Z, Holden S, Hernández-Pinzón I, Scholz U, Mayer KFX, Spannagl M, Pozniak CJ, Sharpe AG, Šimková H, Moscou MJ, Grimwood J, Schmutz J, Stein N (2021)

Long-read sequence assembly: a technical evaluation in barley. Plant Cell. 2021 Mar 12:koab077. doi: 10.1093/plcell/koab077.

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Białas A, Langner T, Harant A, Contreras MP, Stevenson CEM, Lawson DM, Sklenar J, Kellner R, Moscou MJ, Terauchi R, Banfield MJ, Kamoun S (2020)

Two NLR immune receptors acquired high-affinity binding to a fungal effector through convergent evolution of their integrated domain. bioRxiv preprint Jan 27, 2021 doi: https://doi.org/10.1101/2021.01.26.428286

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Panstruga R, Moscou MJ (2020)

What is the molecular basis of nonhost resistance? Mol Plant Microbe Interact. 2020 Aug 18. doi: 10.1094/MPMI-06-20-0161-CR.

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Read AC, Hutin M, Moscou MJ, Rinaldi FC, Bogdanove AJ (2020)

Cloning of the rice Xo1 resistance gene and interaction of the Xo1 protein with the defense-suppressing Xanthomonas effector Tal2h. Mol Plant Microbe Interact. 2020 Aug 4. doi: 10.1094/MPMI-05-20-0131-SC.

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