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Matthew Moscou Group

Our research focuses on understanding the genetic architecture underlying host and nonhost resistance. We use natural and induced variation within host, intermediate host, and nonhost species to identify the genetic loci specifying resistance. Our efforts are concentrated on the cereal rusts and their interaction with several grass species, including wheat (Triticum aestivum), barley (Hordeum vulgare), oat (Avena sativa), and purple false brome (Brachypodium distachyon). We apply a suite of approaches to rapidly accelerate our research, including genetics, bioinformatics, molecular biology, and next-generation sequencing.

Current projects in the group include:

– Genetic architecture underlying host species specificity of stripe rust

– Multiple pathogen resistance specificity at the Mla locus

– Map-based cloning of adult plant resistance QTLs to barley stripe rust

– Distribution, diversity, and expression of the barley NB-LRRome

– Nonhost resistance in Brachypodium spp. to wheat stripe rust

– Suppression of resistance in polyploid genomes

 

Latest Publications

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Bettgenhaeuser J, Hernández-Pinzón I, Dawson AM, Gardiner M, Green P, Taylor J, Smoker M, Ferguson JN, Emmrich P, Hubbard A, Bayles R, Waugh R, Steffenson BJ, Wulff BBH, Dreiseitl A, Ward ER, Moscou MJ (2021)

The barley immune receptor Mla recognizes multiple pathogens and contributes to host range dynamics. Nat Commun. 2021 Nov 25;12(1):6915. doi: 10.1038/s41467-021-27288-3.

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Białas A, Langner T, Harant A, Contreras MP, Stevenson CE, Lawson DM, Sklenar J, Kellner R, Moscou MJ, Terauchi R, Banfield MJ, Kamoun S (2021)

Two NLR immune receptors acquired high-affinity binding to a fungal effector through convergent evolution of their integrated domain. Elife. 2021 Jul 21;10:e66961. doi: 10.7554/eLife.66961.

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de Souza Moraes T, van Es SW, Hernández-Pinzón I, Kirschner GK, van der Wal F, da Silveira SR, Busscher-Lange J, Angenent GC, Moscou M, Immink RGH, van Esse GW (2021)

The TCP transcription factor HvTB2 heterodimerizes with VRS5(HvTB1) and controls spike architecture in barley. bioRxiv preprint Apr 14, 2021 doi: https://doi.org/10.1101/2021.04.14.439785

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Mascher M, Wicker T, Jenkins J, Plott C, Lux T, Koh CS, Ens J, Gundlach H, Boston LB, Tulpová Z, Holden S, Hernández-Pinzón I, Scholz U, Mayer KFX, Spannagl M, Pozniak CJ, Sharpe AG, Šimková H, Moscou MJ, Grimwood J, Schmutz J, Stein N (2021)

Long-read sequence assembly: a technical evaluation in barley. Plant Cell. 2021 Mar 12:koab077. doi: 10.1093/plcell/koab077.

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