Back

Matthew Moscou Group

Our research focuses on understanding the genetic architecture underlying host and nonhost resistance. We use natural and induced variation within host, intermediate host, and nonhost species to identify the genetic loci specifying resistance. Our efforts are concentrated on the cereal rusts and their interaction with several grass species, including wheat (Triticum aestivum), barley (Hordeum vulgare), oat (Avena sativa), and purple false brome (Brachypodium distachyon). We apply a suite of approaches to rapidly accelerate our research, including genetics, bioinformatics, molecular biology, and next-generation sequencing.

Current projects in the group include:

– Genetic architecture underlying host species specificity of stripe rust

– Multiple pathogen resistance specificity at the Mla locus

– Map-based cloning of adult plant resistance QTLs to barley stripe rust

– Distribution, diversity, and expression of the barley NB-LRRome

– Nonhost resistance in Brachypodium spp. to wheat stripe rust

– Suppression of resistance in polyploid genomes

 

Latest Publications

View all

Le Fevre R, O'Boyle B, Moscou MJ, Schornack S (2016)

Colonization of barley by the broad-host hemibiotrophic pathogen Phytophthora palmivora uncovers a leaf development dependent involvement of MLO. Mol Plant Microbe Interact. 2016 Feb 29.

Read more

Dawson AM, Ferguson JN, Gardiner M, Green P, Hubbard A, Moscou MJ (2015)

Isolation and fine mapping of Rps6: an intermediate host resistance gene in barley to wheat stripe rust. Theor Appl Genet. 2016 doi:10.​1007/​s00122-015-2659-x

Read more

Dawson AM, Bettgenhaeuser J, Gardiner M, Green P, Hernández-Pinzón I, Hubbard A, Moscou MJ (2015)

The development of quick, robust, quantitative phenotypic assays for describing the host–nonhost landscape to stripe rust. Front. Plant Sci., 27 October 2015

Read more

Muñoz-Amatriaín M, Lonardi S, Luo M, Madishetty K, Svensson JT, Moscou MJ, Wanamaker S, Jiang T, Kleinhofs A, Muehlbauer GJ, Wise RP, Stein N, Ma Y, Rodriguez E, Kudrna D, Bhat PR, Chao S, Condamine P, Heinen S, Resnik J, Wing R, Witt HN, Alpert M, Beccuti M, Bozdag S, Cordero F, Mirebrahim H, Ounit R, Wu Y, You F, Zheng J, Šimková H, Doležel J, Grimwood J, Schmutz J, Duma D, Altschmied L, Blake T, Bregitzer P, Cooper L, Dilbirligi M, Falk A, Feiz L, Graner A, Gustafson P, Hayes PM, Lemaux P, Mammadov J Close TJ (2015)

Sequencing of 15,622 gene-bearing BACs clarifies the gene-dense regions of the barley genome. Plant J. 2015 Aug 7. doi: 10.1111/tpj.12959.

Read more