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Matthew Moscou Group

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Our research focuses on understanding the genetic architecture underlying host and nonhost resistance. We use natural and induced variation within host, intermediate host, and nonhost species to identify the genetic loci specifying resistance. Our efforts are concentrated on the cereal rusts and their interaction with several grass species, including wheat (Triticum aestivum), barley (Hordeum vulgare), oat (Avena sativa), and purple false brome (Brachypodium distachyon). We apply a suite of approaches to rapidly accelerate our research, including genetics, bioinformatics, molecular biology, and next-generation sequencing.

Current projects in the group include:

– Genetic architecture underlying host species specificity of stripe rust

– Multiple pathogen resistance specificity at the Mla locus

– Map-based cloning of adult plant resistance QTLs to barley stripe rust

– Distribution, diversity, and expression of the barley NB-LRRome

– Nonhost resistance in Brachypodium spp. to wheat stripe rust

– Suppression of resistance in polyploid genomes

 

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Latest Publications

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Wei B, Moscou MJ, Sato K, Gourlie R, Strelkov S, Aboukhaddour R (2020)

Identification of a Locus Conferring Dominant Susceptibility to Pyrenophora tritici-repentis in Barley. Front Plant Sci. 2020 Feb 28;11:158. doi: 10.3389/fpls.2020.00158. eCollection 2020.

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Hiebert CW, Moscou MJ, Hewitt T, Steuernagel B, Hernández-Pinzón I, Green P, Pujol C, Zhang P, Rouse MN, Jin Y, McIntosh RA, Upadhyayac N, Zhang J, Bhavani S, Jan Vrána J, Karafiátová M, Huang L, Fetch T, Doležel J, Wulff BH, Lagudah E, Spielmeyer W (2020)

Stem rust resistance in wheat is suppressed by a subunit of the mediator complex. Nature Communications volume 11, Article number: 1123 (2020)

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Read AC, Moscou MJ, Zimin AV, Pertea G, Meyer RS, Purugganan MD, Leach JE, Triplett LR, Salzberg SL, Bogdanove AJ (2020)

Genome assembly and characterization of a complex zfBED-NLR gene-containing disease resistance locus in Carolina Gold Select rice with Nanopore sequencing. PLoS Genet. 2020 Jan 27;16(1):e1008571. doi: 10.1371/journal.pgen.1008571.

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Read AC, Moscou MJ, Zimin AV, Pertea G, Meyer RS, Purugganan MD, Leach JE, Triplett LR, Salzberg SL, Bogdanove AJ (2019)

Genome assembly and characterization of a complex zfBED-NLR gene-containing disease resistance locus in Carolina Gold Select rice with Nanopore sequencing. bioRxiv preprint Jun 20, 2019 doi: https://doi.org/10.1101/675678

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