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Jonathan Jones Group

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We are interested in how plants resist disease, and in how resistance is overcome by pathogens.  To suppress host defence, pathogens secrete effector proteins into plant cells or into their apoplastic spaces.  How these effectors work, and the identity of their targets in the host, help us understand plant defence mechanisms.

We work on the following problems.

1) How do plant NB-LRR disease resistance proteins recognize pathogen effectors and then activate defence?

2) What are the effectors of the Arabidopsis downy mildew and white rust pathogens (Hyaloperonospora arabidopsidis and Albugo sp), and how do they suppress host defences?

3) Can we find and clone new sources of resistance to potato late blight from wild Solanum species?

Please see our Group Homepage for further details.

Latest Publications

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Castel B, Tomlinson L, Locci F, Yang Y, Jones JDG (2019)

Optimization of T-DNA architecture for Cas9-mediated mutagenesis in Arabidopsis. PLoS One. 2019 Jan 9;14(1):e0204778. doi: 10.1371/journal.pone.0204778.

Castel B, Ngou PM, Cevik V, Redkar A, Kim DS, Yang Y, Ding P, Jones JDG (2018)

Diverse NLR immune receptors activate defence via the RPW8-NLR NRG1. New Phytol. 2018 Dec 24. doi: 10.1111/nph.15659.

Asai S, Furzer OJ, Cevik V, Kim DS, Ishaque N, Goritschnig S, Staskawicz BJ, Shirasu K, Jones JDG (2018)

A downy mildew effector evades recognition by polymorphism of expression and subcellular localization. Nature Communications Volume 9, Article number: 5192 (2018)

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Newman TE, Lee J, Williams SJ, Choi S, Halane MK, Zhou J, Solomon P, Kobe B, Jones JDG, Segonzac C, Sohn KH (2018)

Autoimmunity and effector recognition in Arabidopsis thaliana can be uncoupled by mutations in the RRS1‐R immune receptor. New Phytol. 2018 Nov 30. doi: 10.1111/nph.15617.